摘要:

Antithrombin III (AT II/III) was determined immunologically and by means of a heparin cofactor assay in plasma samples and 24-hour urine of 15 patients with various degrees of proteinuria, being predominantly of glomerular origin. In urine the AT II/III concentrations were significantly correlated to the concentrations of albumin, plasminogen and IgG. One third of the patients had AT II/III plasma levels below the normal range. The plasma levels showed a significant inverse correlation to the AT II/III and albumin clearance rates. Similarily, the plasminogen concentrations in plasma were decreased in two thirds of the patients, being inversely correlated to the renal plasminogen clearance values. It is proposed that AT II/III deficiency in the nephrotic syndrome is an important pathogenetic factor in venous thrombosis.

ISSN:1424-8832    

DOI:10.1159/000214268

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Following myocardial infarction, soluble fibrin in plasma is often elevated as a sign of an activated plasmatic coagulation system. Soluble fibrin in plasma is most pronounced in shock patients under catecholamine administration. With the improvement of the clinical situation the fibrin concentration declines to normal. Following incubation with N-ethylmaleimide an increased production of prostaglandin endoperoxides is observed in the platelets of patients after myocardial infarction compared to normal platelets. Plasma of patients exhibits an endoperoxide-producing effect on normal platelets. The stimulating effect of patient plasma diminishes together with the fall of soluble plasma fibrin. These phenomena may be considered as signs of a relation between the plasmatic and throm-bocytic coagulation system.

ISSN:1424-8832    

DOI:10.1159/000214269

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Rat carotid arteries were injured electrically (350 V, 2 mA DC for 5 min) before and after the intravenous administration of heparin (1,000 U/kg), VK 744 (25, 50, 100 mg/kg) ASA (100, 200 mg/kg) and sulfinpyrazone (50, 100, 150, 200 mg/kg). Thrombus growth was quantified by recording arterial temperature change distal to the injury. Heparin completely blocked thrombus formation in most experiments. All other agents exhibited antithrombotic activity with sulfinpyrazone being most potent. None was as effective as heparin. This model may be a useful tool for screening antithrombotic drugs.

ISSN:1424-8832    

DOI:10.1159/000214270

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Acetylsalicylic acid (ASA) did not prevent the arrhythmias induced in rats by a bolus intravenous injection of ADP, an effect independent of platelets. ASA was also unable to protect the rats from the platelet-mediated cardiovascular effects and myocardial ischaemia induced by a prolonged ADP infusion. It is suggested that the release of vasoactive substances inhibited by ASA does not play a major role in the cardiovascular effects of ADP in rats.

ISSN:1424-8832    

DOI:10.1159/000214271

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Both viscosity of blood and the rigidity of red cells are of consequence in the mechanism of hypertension. While the details of this mechanism are still elusive, the evidence presented might open the way for a wider inquiry into the role of blood rheology in hypertension.

ISSN:1424-8832    

DOI:10.1159/000214272

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Histochemical studies of the aorta in newborn, young, and adult rats showed that the intima in the branching regions and at the beginning of the branches has a constantly increased plasminogen activator activity in comparison with the nonbranching regions. The aortic valve also shows constantly increased activator activity. The intimal activator activity is variable in the nonbranching regions, depending on the age and the anatomical area of the aorta. In young rats (20–30 days), the overall plasminogen activator activity in the aortic intima is higher than in adult rats (2–4 months), while the activity is variable in newborn ratsi The intimal activator activity is generally higher in the thoracic aorta than in the abdominal aorta (in the nonbranching regions). The aortic wall has a low plasmin inhibitor capacity. The pattern of the endothelial plasminogen activator activity at different ages and anatomical areas of the aorta, in combination with the corresponding pattern of the aortic endothelial cell turnover, gives valuable information about the mechanism(s) of the production and normal (nonstressed) release of the endothelial plasminogen activa

ISSN:1424-8832    

DOI:10.1159/000214273

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000214274

出版商:S. Karger AG    

年代:1978

数据来源: Karger