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| 1. |
Increased Release of Vascular Prostacyclin-Like Activity after Long-Term Treatment of Diabetic Rats with Bay g 6575 |
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Pathophysiology of Haemostasis and Thrombosis,
Volume 10,
Issue 6,
1981,
Page 297-303
D.A.F. Chamone,
B. van Damme,
L.O. Carreras,
J. Vermylen,
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摘要:
10 male Wistar rats were made diabetic by an intravenous injection of streptozotocin. 10 sex and age-matched rats served as control animals. 5 of the diabetic and 5 of the control rats received Bay g 6575 (20 mg/kg orally) for 6 days each week throughout the whole study period (9–11 months). From these animals aorta was removed for prostacyclin bioassay based upon its platelet aggregation inhibitory effect. The diabetic rats treated with Bay g 6575 released significantly more prostacyclin than the controls (p < 0.005). Our study suggests further experiments in other animal models more susceptible to diabetic vascular lesions than the rat model to evaluate the possible beneficial role of the treatment with Bay g 657
ISSN:1424-8832
DOI:10.1159/000214415
出版商:S. Karger AG
年代:1981
数据来源: Karger
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| 2. |
The Influence of Various Combinations of Plasminogen and Streptokinase on Fibrinolysis |
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Pathophysiology of Haemostasis and Thrombosis,
Volume 10,
Issue 6,
1981,
Page 304-314
Patrick J. Gaffney,
Franklin Joe,
Edith A. Rowe,
A.N. Whitaker,
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摘要:
The lysis rates of 125I cross-linked plasma fibrin clots have been investigated following immersion in various buffered concentrations of streptokinase (SK), prior to (called the SK → plgn regimen) and after (called the plgn → SK regimen) enrichment with 2.0 U of plasminogen (plgn, lys-type). The SK → plgn regimen usually achieved total clot lysis with the most active lysis occurring following enrichment in 125–130 IU SK solutions, while only partial lysis was observed during the plgn → SK procedure. The effect of SK concentration was marked during the SK –plgn regimen while, during the plgn → SK treatment, its lytic rate effect never exceeded a factor of 2.0 over a wide concentration range of SK (8.0–20,000 IU/ml. The availability of plasminogen to perfuse the activator-rich clot seemed to be the prevailing influence on clot lysis and lysis of clots in plasma was inhibited by serum inhibitors, SK antibodies and pl
ISSN:1424-8832
DOI:10.1159/000214416
出版商:S. Karger AG
年代:1981
数据来源: Karger
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| 3. |
Inhibition of Activated Factors II, VII, IX, and X by Synthetic Organic Compounds Directed against the Active-Site Seryl Residue |
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Pathophysiology of Haemostasis and Thrombosis,
Volume 10,
Issue 6,
1981,
Page 315-347
J.A. v.d. Woerd-de Lange,
M.C.E. van Dam-Mieras,
H.C. Hemker,
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摘要:
A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.
ISSN:1424-8832
DOI:10.1159/000214417
出版商:S. Karger AG
年代:1981
数据来源: Karger
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| 4. |
Announcement |
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Pathophysiology of Haemostasis and Thrombosis,
Volume 10,
Issue 6,
1981,
Page 348-348
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ISSN:1424-8832
DOI:10.1159/000214418
出版商:S. Karger AG
年代:1981
数据来源: Karger
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| 5. |
Author Index |
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Pathophysiology of Haemostasis and Thrombosis,
Volume 10,
Issue 6,
1981,
Page 349-350
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PDF (219KB)
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ISSN:1424-8832
DOI:10.1159/000214419
出版商:S. Karger AG
年代:1981
数据来源: Karger
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| 6. |
Subject Index |
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Pathophysiology of Haemostasis and Thrombosis,
Volume 10,
Issue 6,
1981,
Page 351-352
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PDF (273KB)
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ISSN:1424-8832
DOI:10.1159/000214420
出版商:S. Karger AG
年代:1981
数据来源: Karger
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| 7. |
Contents, Vol. 10, 1981 |
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Pathophysiology of Haemostasis and Thrombosis,
Volume 10,
Issue 6,
1981,
Page -
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PDF (828KB)
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ISSN:1424-8832
DOI:10.1159/000214414
出版商:S. Karger AG
年代:1981
数据来源: Karger
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