摘要:

Procollagen-induced platelet aggregation, platelet retention (Hellem II), and platelet factor 3 availability (PF-3) were determinded in a group of healthy volunteers, acetylsalicylic acid (ASA) treated patients and in uraemic patients. ASA ingestion did not influence platelet retention and PF-3 availability. Uraemic patients had a pronounced decrease in platelet aggregation and retention and PF-3 availability revealed inconsistent alterations. The relevance of the tests and the benefit of an ASA treatment for prophylaxis of thrombosis in Cimino fistulae are discussed.

ISSN:1424-8832    

DOI:10.1159/000214047

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Ristocetin-induced platelet aggregation was increased after exercise in 5 healthy volunteers. It was shown that this was the result of the increase of a plasmatic factor.

ISSN:1424-8832    

DOI:10.1159/000214048

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The recovery of factor VIII-activity in cryoprecipitate prepared from plasma from six patients with von Willebrand’s disease was low as compared to the recovery from normal and hemophilia-A plasma. The possible cause is briefly discusse

ISSN:1424-8832    

DOI:10.1159/000214049

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The evaluation of microhaematuria may be considered as a measure of the haemostatic defect of haemophiliacs in nonhaemorrhagic periods. In order to study the relationship between coagulation disorder and haemostatic defect we have administered small amounts (1 U and 3 U/kg) of AHG and of factor IX (1 U/kg) to 12 haemophiliacs (10 A and 2 B) and we have examined the effects on coagulation and microhaematuria. Microhaematuria was determined by the measurement of urinary radioactivity/24 h, after infusion of autologous RBC labelled with 51Cr, for 11 consecutive days (4 days before and 7 after the administration). Coagulation was investigated by thromboelastography, PTT, Quick’s time, PCI, factor VIII and IX activity assays, fibrinogen assay, and euglobulin lysis time. During the period of investigation, the patients remained in bed. In controls, factor VIII administration did not affect microhaematuria. On the other hand, in all haemophiliacs, factor VIII and IX administration significantly reduced microhaematuria, although the administered dose was not able to modify the coagulation defect. In all subjects the reduction of microhaematuria lasted at least 5 days. The correction of the haemostatic defect, without improvement of the clotting disorder, and its persistence for several days suggest that factor VIII is involved in the composition of the vascular wall and in its functional integrity. Moreover, on the basis of these results it is possible to carry out a rational prophylaxis of the haemorrhagic episodes using small doses of factor VIII, by determining the duration of the correction of the haemostatic defect for each subjec

ISSN:1424-8832    

DOI:10.1159/000214050

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Multiple components of the fibrinolytic mechanism (plasminogen, plasmin, antiplasmin, fibrinogen, fibrin degradation products) and factor II (prothrombin) levels were studied in 40 children with cyanotic congenital heart disease (CCHD) prior to corrective surgery. Seven of these were also studied post-operatívely. A further 17 children were studied after corrective surgery only. Pre-operatively, increased fibrinolysis could be demonstrated in only 7.5–12% of patients, and there was no correlation between the levels of fibrinolytic components and the severity of polycythemia or post-operative blood loss. There was no evidence of fibrinolysis post-operatively. Pre-operatively, low prothrombin levels were common (25 %), were correlated with the amount of post-operative blood loss and were restored to normal by corrective surgery. Hypoprothrombinaemia is one of the most significant haematological abnormalities in CC

ISSN:1424-8832    

DOI:10.1159/000214051

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A patient with a fulminant clinical course of disseminated intravascular coagulation (DIC) is described. The DIC was first manifested by neurological symptoms and later dominated by hemorrhagic phenomena. Bleeding manifestations were not controlled by treatment with heparin, later supplemented with ε-amino-caproic acid and fresh blood. The patient’s condition precluded the performance of extensive diagnostic procedures. On the assumption that malignancy was the underlying disease, cyclophosphamide and hydrocortisone were administered. In spite of intensive treatment the patient died. Autopsy revealed mesenteric lymph node metastases of a mucinous adenocarcinoma, probably originating in the colon. It is emphasized that in some patients with malignant disease, acute DIC is the presenting and the predominant symptom. In such patients the hemorrhagic manifestations may not be controlled unless the underlying neoplastic disease is detected and treat

ISSN:1424-8832    

DOI:10.1159/000214052

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A case of an acquired circulating anticoagulant occurring in a patient suffering from chronic lymphocytic leukaemia with haemolytic anaemia and autoimmune disorders has been reported. The anticoagulant was found to belong to the IgM class. Coagulation studies show that this anticoagulant inhibits the reaction between human prothrombinase and factor II.

ISSN:1424-8832    

DOI:10.1159/000214053

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000214054

出版商:S. Karger AG    

年代:1974

数据来源: Karger