摘要:

The thrombin-inactivating α2-globulin, antithrombin III (At-III), was measured in plasma and urine with a chromogenic tripeptide substrate, using a centrifugal analyzer. Plasma At-III was subnormal in liver disease. In acute myocardial infarction a mean At-III of approximately 120% of normal was found. At-III in persons who developed deep-vein thrombosis decreased significantly (p < 0.05) between the day of admission and the 3rd day after admission to hospital. Urine from normals did not contain detectable At-III. With increasing urinary albumin increasing concentration of At-III was found

ISSN:1424-8832    

DOI:10.1159/000214342

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Two patients with angiographically proven longitudinal sinus thrombosis were studied from a coagulation point of view. In the first case, marked primary thrombocytosis was found. This patient was treated with aspirin, dipyridamole and radioactive phosphorus. In the second case, fibrinogen and whole blood plasma viscosity were elevated. This patient developed deep vein thrombosis of the left leg a few weeks after the cerebral episode and was treated with coumarin drugs. The importance of a coagulation study in every patient with cerebral vein thrombosis is emphasized.

ISSN:1424-8832    

DOI:10.1159/000214343

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A 14-year-old girl presented with severe haemorrhagic diathesis. Her past history suggested a congenital bleeding disorder. Investigations disclosed severe deficiency of all four vitamin K-dependent factors and a functional defect of platelets. These were caused by simultaneous administration of vitamin K antagonists and anti-inflammatory drugs. A complete clinical and laboratory recovery took place following withdrawal of drugs. The severity of the haemorrhagic diathesis prompted us to describe the case in order to draw the attention of medical personnel to the dangerous potentiation effects of different drugs administered with vitamin K antagonists.

ISSN:1424-8832    

DOI:10.1159/000214344

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Certain properties of tissue transamidase isolated from a bovine spleen have been described. This enzyme, like factor XIII (FSF), after reaction with thrombin causes the transformation of soluble fibrin polymer into insoluble clot – desmofibri

ISSN:1424-8832    

DOI:10.1159/000214345

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The binding of adenosine and adenylnucleotides to the human platelet membrane has been measured and the subsequent effect on the binding of 14C-ADP has been determined. The following conclusions have been drawn: (1) Two reactions with different velocities (t 1/2 = 15–30 sec and t 1/2 = 4–6 min) seem to be involved in the binding of ADP to the platelet membrane. (2) AMP binds to the platelet membrane and partially inhibits binding of ADP in a competitive manner. These two findings suggest that ADP binding sites on the platelet membrane may be of more than one type. (3) At concentrations up to 10-5 M, ATP does not itself bind to the platelet membrane but is rapidly transformed into ADP which, in turn, binds to the membrane and inhibits the binding of 14C-ADP. (4) Adenosine does not significantly interfere with the binding of 14C-ADP and has not been shown to bind to the platelet membr

ISSN:1424-8832    

DOI:10.1159/000214346

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The results of detailed studies of 3 patients with essential thrombocythaemia (ET) are presented. Qualitative tests of platelet function were abnormal, and autologous platelet survivals were diminished. Megakaryocyte ploidy distribution analysis showed an increased proportion of cells with high ploidy, and buoyant density distribution analysis showed increased proportions of less dense platelets. Ultrastructural studies of the platelets showed proliferation of the dense tubular system with deficiency of the surface-connected canalicular system. Megakaryocyte electron microscopy showed abnormal distribution of demarcation membrane complex and granules.The precise functional abnormality of the platelets in ET has not yet been defined, but a release defect of variable severity with corresponding morphological abnormalities of the dense tubular and surface-connected canalicular systems, seems the most likely explanation.

ISSN:1424-8832    

DOI:10.1159/000214347

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Plasmatic β -thromboglobulin (BTG) has been assayed in 5 patients with May-Hegglin anomaly. All patients showed a normal BTG plasmatic level. The plasma BTG/number of platelets ratio resulted to be elevated but this was due to the low platelet count typical of the disease. The platelet content in BTG was studied in only 2 patients and was found to be four times the normal value; however, the circulating BTG platelet mass in these patients resulted to be within normal limits

ISSN:1424-8832    

DOI:10.1159/000214348

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000214349

出版商:S. Karger AG    

年代:1980

数据来源: Karger