摘要:

2 patients treated with penicillin and ampicillin, respectively, suffered from haemorrhagic diathesis, haemolysis, cerebral symptoms and renal insufficiency, resembling a haemolytic-uraemic syndrome. Their plasma was red due to the presence during several days of haemoglobin-haptoglobin complexes, the P-haemoglobin being 2.8 and 1.6 g/l, respectively. Coagulation tests showed an unusual pattern with prolonged activated partial thrombo-plastin times, an extremely long thrombin time and very high levels of fibrinogen degradation products. Repeated transfusion had no effect. The patients were considered to have developed a drug-induced serum sickness associated with insufficient function of the reticuloendothelial system, and secondary to this an accumulation of haemoglobin-haptoglobin complexes in plasma. When the penicillin drugs were discontinued, all measured variables rapidly normalised and the patients recovered completely. Thus, the haemolytic-uraemic syndrome seemed to be caused by the serum sickness, possibly via circulating or cell-associated immune complexes. The possibility of a type III allergic reaction should be considered in patients with haemolytic-uraemic-like syndromes.

ISSN:1424-8832    

DOI:10.1159/000214358

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

5 patients suffering from von Willebrand’s syndrome were treated with DDAVP administered intravenously or intransally. The concentration of F. VIII-related activities (F. VIII:C, F. VIII R:AG, F. VIII R:WF), as well as the mobility of F. VIII R: AG in crossed immunoelectrophoresis and the alterations of bleeding time were continuously monitored. DDAVP induced both quantitative and qualitative changes of F. VIII-related properties. The bleeding time was markedly reduced for some hours. The therapy was well tolerated and should be submitted to further clinical trials as a possible way to avoid the disadvantages connected with the transfusion of blood component

ISSN:1424-8832    

DOI:10.1159/000214359

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A new case of congenital dysfibrinogenaemia was found in 2 members of the same family. The anomaly was characterized by an abnormal polymerization of fibrin monomers, whereas the release of fibrinopeptides by thrombin and fibrin stabilization by F XIII were normal. Investigation of the fibrinogen molecule did not lead to localizing the structural abnormality.

ISSN:1424-8832    

DOI:10.1159/000214360

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Release of platelet antiheparin activity (platelet factor 4, PF4) induced by collagen and l-epinephrine, is normal in newborn infants without antenatal drug exposure. In contrast, PF4 release in platelets of infants of mothers with membrane-stabilizing drug ingestion is decreased to a greater extent than in their respective mothers. Platelet aggregation gives a qualitative indication of response. Platelets of mothers with antenatal drug exposure and those of their infants showed only a one-wave response to adenosine diphos-phate, while platelets of these same mothers still showed a two-wave aggregation response to l-epinephrine. In contrast, platelets of all neonates lacked epinephrine-induced aggregation response, even when washed and resuspended in adult plasma. Our studies show that prenatal drugs have an effect on the platelet release mechanism in both mothers and their exposed infants; but the effect on the epinephrine-induced platelet response is less in mothers. Newborn infants have different aggregation and platelet release response to epinephrine which suggests that platelet aggregation and the release reaction can occur independently of each other.

ISSN:1424-8832    

DOI:10.1159/000214361

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Exercise was found to cause the release of ‘extrinsic’ plasminogen activators into the bloodstream. The ‘intrinsic’ plasma plasminogen activators were not significantly altered although factor VIII clotting activity and, to a lesser extent, its related antigen were both raised. A small amount of systemic fibrin(-ogen)olysis was indicated by the generation of fragment X and a slight reduction in the amount of intact Aα-fibrinogen chain present. Plasminogen and antiplasmins were not significantly affected by exercise. We conclude that exercise-induced fibrinolysis is brought about solely by the release of plasminogen activators(s) from the vessel wall but that this enhanced level of fibrinolysis is insufficient to produce a marked degree of systemic fιbrin(ogen)

ISSN:1424-8832    

DOI:10.1159/000214362

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Treatment of human citrated plasma with glass has complex effects on the fibrinolytic system. While the spontaneous euglobulin activity is only slightly affected by the glass treatment, the activity precipitated in the presence of dextran sulphate diminishes rapidly with increasing amounts of glass. With common glass a minimum is reached, and the activity reappears when larger amounts of glass are used. With Pyrex glass the decrease continues. Addition of flufenamate to the solutions recover much of the missing activity suggesting the presence in the euglobulin precipitates of an inhibitor sensitive to flufenamic acid. Heating of plasma at 56°C rapidly destroys its ability to produce spontaneously active euglobulin precipitates while the capacity to elicit fibrinolytic activity by precipitation in the presence of dextran sulphate remains largely undisturbed suggesting a relative stability of the precursors of the intrinsic fibrinolytic system

ISSN:1424-8832    

DOI:10.1159/000214363

出版商:S. Karger AG    

年代:1980

数据来源: Karger