ISSN:1424-8832    

DOI:10.1159/000215857

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000317835

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000317836

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000317837

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

More than 75% of all Dutch haemophiliacs participated in a mail survey that included a section on acquired immunodeficiency syndrome (AIDS). Although no cases of haemophilia-related AIDS had been reported in the Netherlands at the time of our survey, the threat of AIDS had caused considerable anxiety among Dutch haemophiliacs. This had led almost a third of the patients to change their therapy schedules. These changes were mostly not beneficial and possibly counterproductive, since they were not likely to reduce the risk of human immunodeficiency virus (HIV) infection. Measures that were advised to prevent HIV transmission, such as the use of condoms, were seldom carried out, even by the 17% seropositive individuals. We conclude that an increase in the informational efforts towards the patients is called for to avoid ill-advised treatment changes and to enhance preventive behaviour.

ISSN:1424-8832    

DOI:10.1159/000215786

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000317838

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

We examined the time course of the development of hemorrhagic synovitis in response to repeated autologous blood injections into knee joints in mature dogs and the possible usefulness of joint imaging with technetium-99m pyrophosphate (Tc99m-PYP) in monitoring the early response of synovium to blood. Experimental hemarthrosis was induced in dogs by twice weekly injection of autologous blood into the knee joints. Sequential examination of the synovium at monthly intervals over a period of 12 weeks revealed early inflammatory cell infiltration and capillary neovascularization with eventual replacement of the normal fatty synovium by dense fibrous tissue. Serial Tc99m-PYP joint images demonstrated a progressive increase in isotope accumulation in the knees during the course of the study. Further isotope accumulation was observed after CO2 laser synovectomy. During the 24-week course of the entire study, no changes in joint cartilage or bone were observed by gross inspection or radiologic and light-microscopic examination. The findings indicate that the progressive proliferative, inflammatory, fibrotic changes in joint synovium associated with experimental hemarthrosis in dogs may be noninvasively and semiquantitatively assessed with the use of Tc99m-PYP scintigraphy. Evidence is also presented that the intensity of Tc99m-PYP joint accumulation (immediate static images) may not readily reflect synovial vascularity or synovial tissue mass.

ISSN:1424-8832    

DOI:10.1159/000215787

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The influence of four hydroxil radical (OH•) scavengers on platelet function was investigated. OH• scavengers inhibited ADP, collagen, arachidonic acid, PAF-induced platelet aggregation, and platelet cyclooxygenase pathway activation, which was studied by evaluating platelet malondialdehyde and serum thromboxane A2 formation. The latter was not affected by superoxide dismutase, catalase, or metal ion chelants such as desferioxamine or DETAPAC. The detection of deoxyribose degradation by stimulated platelets suggested that platelets produce OH•. This study shows that activated platelets produce free radicals and that antioxidant agents such as OH• scavengers inhibit platelet f

ISSN:1424-8832    

DOI:10.1159/000215788

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The effect of purified fibrin(ogen) degradation product fragment D on cultured bovine aortic endothelial cells has been investigated. Binding to the cells was studied using purified radiolabelled fragment D and assessment of its recently postulated deleterious action was made by three different approaches: release of 51Cr from prelabelled cell layers, uptake of 3H-adenine by the cultivated cells as well as determination of residual cell number after exposure to various concentrations of fragment D were carried out. None of these methods applied was able to detect any harmful effect of the fragment on endothelial cell integrity and function in vitro. Neither could a specific interaction of the protein with the cultured cells be established. Even huge amounts of fragment D (1 mg/ml) exposed to the cells over 20 h did not reveal any alterations in the typical monolayer morphology. Thus, fragment D, which is generated in large amounts during systemic fibrinolytic treatment, does not exert any perturbation on cultured vascular endothelial cells as had previously been proposed.

ISSN:1424-8832    

DOI:10.1159/000215789

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1424-8832    

DOI:10.1159/000317839

出版商:S. Karger AG    

年代:1988

数据来源: Karger