ISSN:1424-8832    

DOI:10.1159/000214350

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Increases in endogenous free fatty acids (FFA) induced by several stimuli are associated with increases in platelet aggregates and platelet factor 4 in man. To determine if thromboxane (TxB) release is also an associated event, we measured plasma FFA and TxB2 levels before and 5 min after bolus injection of 2,500 U of heparin prior to coronary arteriography in 27 patients with angina. Significant increases in FFA occurred in all patients (p < 0.02) and those with critical lesions (p < 0.01), while TxB2 levels also rose (p < 0.02, p < 0.05, respectively). However, linear regression showed increases in FFA and TxB2 were independent. The observed TxB2 release may be due to lipolysis-induced exposure of vascular collagen or direct inhibition of platelet adenylate cyclase by heparin.

ISSN:1424-8832    

DOI:10.1159/000214351

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Platelet-poor plasmas (PPPs) from 52 out of 71 patients affected by different diseases and selected for increased amounts of circulating platelet aggregates, incubated at 37 °C for 30 min with control platelet-rich plasma (PRP; cross-matching test) induced the formation of platelet aggregates, stimulated the production of malondialdehyde and enhanced ADP-induced aggregation. 31 control PPPs were consistently negative at cross-matching test. Gel chromatography of plasmas on agarose 4% allowed the identification of four different fractions (A, B, C, D) provided with aggregating activity. Fraction A eluted at the void volume was to be identified with the von Willebrand factor, whereas B, C and D fractions, eluted at the same elution volumes as activated factor X were mainly composed of factor X (fraction B) and activated factor X (fractions C and D). Thrombin activity was absent in all the fractions provided with aggregating activity. Also, from control PPPs negative at cross-matching tests, the same fractions could be obtained, although of 5–10 times lower aggregating potency, thus explaining the negative cross-matching tests. These findings stress the role of some extraplatelet factors related to hypercoagulability in platelet hyperaggregabili

ISSN:1424-8832    

DOI:10.1159/000214352

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Factor VIII-related antigen was assayed in adults in venous citrated samples and in samples taken with heparinized and plain capillaries blown out in citrate. The three sampling methods gave nearly identical results in a wide range of values. Two of the sampling methods were used in newborns and again the results showed excellent correlation.

ISSN:1424-8832    

DOI:10.1159/000214353

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A hemostatic survey was done on 14 Bedlington terriers, 13 of which have the recently discovered copper toxicosis. Their hepatic copper ranged from 109 to 9,888 μg/g dry weight and their ages form 8 months to 8 years. Despite histologic evidence of hepatitis in younger dogs and cirrhosis in older ones, plasmatic coagulation factors were not depressed. In fact, the hemophilic factors VIII, IX and XI were above normal, more closely related to the age of the dog than to the hepatic copper. Furthermore, their platelets were unusually sensitive to adenosine diphosphate exposure. Offsprings of matings between Bedlington terriers and Beagles seem to be normal

ISSN:1424-8832    

DOI:10.1159/000214354

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

In the intima of a vein grafted into the aorta, the thromboplastic activity during the first 4 months after the operations is higher than in the artery and vein. At the same time, the plasminogen activator activity of the venous graft is also higher than that of the artery but lower than that of the vein. In the later post-operative period, both activities of the intima of the venous graft closely approaches those of the intima of the normal vein. In the media the thromboplastic activity is lower in the graft and the plasminogen activator content is higher than in the artery and vein. However, the thromboplastic and fibrinolytic activity in the adventitia of the venous graft, artery, and vein did not change significantly during the 36-month observation period of the experiment.

ISSN:1424-8832    

DOI:10.1159/000214355

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Rabbit skin, normally of low fibrinolytic activity, and guinea-pig skin, of medium activity, after crush injury or after the intradermal or subcutaneous injection of aluminum hydroxide, show a remarkable increase in fibrinolytic activity. The activity is caused by a plasminogen activator and is related to blood vessels. Occasionally, intense fibrinolytic activity was also observed in some specimens collected from various other organs normally low in activity. Thus two specimens of rabbit aorta, one specimen of rabbit trachea and one specimen of rabbit stomach showed increased activity related to pathological processes. One specimen of guinea-pig rectum showed intense fibrinolytic activity along the serosa.

ISSN:1424-8832    

DOI:10.1159/000214356

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The anticoagulant used for blood collection may modify platelet aggregation. In platelet-rich citrated plasma, adrenaline induced biphasic aggregation accompanied by 14C-serotonin release, whereas in platelet-rich hirudin plasma it induced weak primary aggregation. In plasma from blood anticoagulated simultaneously with hirudin and citrate, adrenaline caused biphasic aggregation as it was observed in citrated plasma. Qualitative differences in platelet reaction in hirudin citrated plasma were found to be dependent on calcium ion concentration. Therefore, the deprivation of calcium ions by citrate is considered the cause of the adrenaline effect in citrated plasma.

ISSN:1424-8832    

DOI:10.1159/000214357

出版商:S. Karger AG    

年代:1980

数据来源: Karger