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1. |
Chronic T‐cell leukaemias. A variant of T‐prolymphocytic leukaemias: morphological, immunological and clinical characterization of 2 cases |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 1-6
F. Lauria,
R. Foà,
D. Raspadori,
P. L. Tazzari,
N. Migone,
M. C. Giubellino,
P. Lusso,
M. T. Fierro,
M. R. Motta,
A. Tassinari,
M. Buzzi,
S. Tura,
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摘要:
In this study we describe 2 patients who appear to suffer from a morphological, cytochemical and clinico‐haematological variant of T‐prolymphocytic leukaemia (T‐PLL). The cells were smaller than typical prolymphocytes, with a regular nucleus containing a smaller and less prominent nucleolus; the alpha‐naphthyl acetate esterase (ANAE) and acid phosphatase (AP) cytochemical reactions showed a weaker pattern of positivity in this variant compared to T‐PLL. No immunological differences were found between the two conditions with regard to membrane expression and functional behaviour of the cells. The clinical course and the outcome of the patients appears to be different: aggressive and rapidly fatal in T‐PLL; thus far well‐controlled in the T‐PLL variant. From a molecular point of view, both cases showed a monoclonal rearrangement of the T‐cell rece
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00154.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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2. |
The effect of an isoprenaline infusion on the splenic blood flow and intrasplenic platelet kinetics |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 7-13
Hans Wadenvik,
Jack Kutti,
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摘要:
The effect of a constant isoprenaline infusion on the venous platelet count, splenic blood flow and intrasplenic platelet kinetics was investigated in 6 healthy male volunteers. The study was carried out using autologous111In‐labelled platelets and dynamic gamma camera imaging of the initial distribution of radiolabelled platelets between blood and splenic platelet pool. The isoprenaline infusions were administered i.v. over 30 min in a dose of 0.03 μg/kg/min. These infusions significantly increased the splenic blood flow and the size of the exchangeable splenic platelet pool. Concomitantly, there was a decrease of labelled as well as unlabelled platelets in the peripheral blood. The intrasplenic platelet transit time was not affected. Before start of infusion, the splenic blood flow was 6.1 ± 2.9 (SD) % of total blood volume/min and the splenic platelet pool size 34 ± 9 (SD) %. During infusion the corresponding values were 8.7 ± 3.9 (SD) and 41 ± 11 (SD), respectively. It is concluded that an i.v. infusion of isoprenaline enhances splenic pooling of platelets as a result of an increase in splenic bloo
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00155.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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3. |
Plasma lipids in juvenile chronic granulocytic leukaemia |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 14-17
E. Turpin,
G. Leverger,
D. Erlich,
D. Neel,
P. Beaudry,
C. Dreux,
Y. Goussault,
G. Schaison,
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摘要:
Plasma lipid parameters (triglycerides, total cholesterol and high density lipoprotein cholesterol) were measured in 7 children with juvenile chronic granulocytic leukaemia, of whom 3 were with and 4 without xanthomas. In all cases, whatever the stage of the disease, these parameters were extremely altered. Plasma triglycerides were generally increased, total and HDL cholesterols were very low. No relationship seems to exist between these values and the occurrence of xanthomas.
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00156.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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4. |
Characterization of lymphocyte subpopulations in human cord blood using the immunogold staining technique |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 18-22
Oluyemisi J. Fatunde,
Sandra S. Kaplan,
Janet B. Lochner,
Lila Penchansky,
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摘要:
Lymphocyte subpopulations in human cord blood have been examined using monoclonal antibodies, visualized with immunogold. The proportions of T11, T4, T8, and B1, cells in cord blood are very similar to values in adult peripheral blood. Some evidence of lymphocyte immaturity in cord blood is suggested by the presence of 12% CALLA‐positive cells and the sum of T4and T8cells significantly exceeding the number of T11cells; however, there were no TdT‐positive cells. The presence of CALLA‐positive lymphocytes in normal cord blood should be borne in mind when investigating blood smears from neonates for congenital leu
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00157.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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5. |
Antioxidant system and serum trace elements in α‐thalassaemia and Hb Lepore trait |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 23-27
G. C. Gerli,
R. Mongiat,
M. T. Sandri,
A. Agostoni,
V. Gualandri,
G. B. Orsini,
G. P. Buso,
G. Moschini,
G. Carpani,
F. Marini,
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摘要:
Erythrocyte antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase were found to be significantly high in subjects with α‐thalassaemia and Hb Lepore trait, as a consequence of the increased oxidant stress which is known to exist in these conditions. Among the serum trace elements present in these enzymes, selenium was increased in subjects with Hb Lepore trait and significantly low in those with α‐thalassaemia trait, while selenium erythrocyte content was significantly increased in α‐thalassaemic
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00158.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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6. |
Neutrophil dysfunctions in thalassaemia major: The role of cell iron overload |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 28-34
B. Cantinieaux,
C. Hariga,
A. Ferster,
E. Maertelaere,
M. Toppet,
P. Fondu,
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摘要:
The susceptibility to infections was recorded in 13 patients with β thalassaemia major (T.P.). The following parameters were also investigated in their polymorphonuclear neutrophils (PMN): nitro blue tetrazolium (NBT) reduction, heated yeast and Escherichia coli phagocytosis, Escherichia coli killing and myeloperoxydase activity. These results were compared to those obtained in healthy controls (H.C.). The Perls's reaction was performed on PMN and graded according to a scoring system with the aim of quantifying the iron intoxication of PMN. Phagocytosis and Perls's reaction of PMN from H.C. were also studied after 20 h of incubation with thalassaemic serum. 6 T.P. out of 13 developed septicaemia during their lifetime and in all 9 septicaemic episodes were noted. Phagocytosis was greatly impaired, disclosing both cellular and serum abnormalities. The mean percentage of Perls's positive PMN was 13% in T.P., contrasting with the constant negative reaction in H.C. The incubation of PMN from H.C. with serum from T.P. induced the simultaneous appearance of a phagocytosis defect and of a positive Perl's reaction. It was concluded that in β thalassaemia major the phagocytosis of PMN was altered due to a combination of serum and cellular abnormalities and that both may be related to the iron overloa
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00159.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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7. |
1α(OH)D3(ETALPHA)® treatment and receptor studies in 16 patients with chronic and myeloproliferative disorders |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 35-38
Steen Bo Wieslander,
Børge T. Mortensen,
Lise Binderup,
Nis I. Nissen,
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摘要:
10 patients with CLL and 2 with CML were treated with gradually increasing doses of 1α(OH)D3, up to 4 μg daily during 6 wk. 3 patients with preleukemia and 1 with myelofibrosis were treated with 2 μg daily of 1α(OH)D3for a prolonged period up to 17 wk. The treatment with 1α(OH)D3did not result in changes of disease parameters in any of the patients under study. Receptor studies for 1,25(OH)2D3were performed in 8 CLL patients and revealed only 1 patient with increased specific receptor binding capacity. The maximum tolerable dose of 1α(OH)D3varied individually, but was in the range of 2–4
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00160.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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8. |
Whole blood folate values in pernicious anaemia: Relation to treatment |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 39-43
Erik M. Magnus,
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摘要:
27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12preparations, while during intervening period no therapy was given until signs of B12deficiency developed. After vitamin B12treatment, a peak whole blood folate value some 70% higher than the starting value was noted after about 75 d in patients treated with B12injections and after about 165 d in perorally treated patients. During the same time significantly increased whole blood folate/plasma folate ratio was noted. In most of the patients, whole blood folate declined from peak to plateau level in about 150 d and thereafter remained almost unchanged until signs of cobalamin deficiency developed. The mean time from peak to plateau values was significantly longer in “long‐reactors” than in “short‐reactors”. Higher peak and plateau values were noted in patients with neuropathy and mucosal symptoms, as compared to patients with hypers
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00161.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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9. |
HIV infection in Norwegian haemophiliacs: The prevalence of antibodies against HIV in haemophiliacs treated with lyophilized cryoprecipitate from volunteer donors |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 44-48
S. A. Evensen,
J. Ulstrup,
K. Skaug,
S. S. Frøland,
A. Glomstein,
H. Rollag,
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摘要:
334 of 389 (86%) registered Norwegians with coagulation factor defects were screened for antibodies to the human immunodeficiency virus (HIV) in 1985/1986. 21 persons were confirmed anti‐HIV positive. They were all persons with clinically severe haemophilia A and represent 18.4% of 114 tested persons with severe haemophilia A. 3 patients have developed AIDS, 3 have persistent generalized lymphadenopathy. At least 8 of the 21 seropositive persons (38%) have been infected through lyophilized cryoprecipitates prepared from volunteer plasma donated in national blood banks. None of 10 heterosexual partners have antibodies to HIV. We conclude that the policy of using small‐pooled lyophilized cryoprecipitates instead of commercial concentrates has reduced HIV‐infection among Norwegian haemophiliacs. Today, the prevalence of HIV antibodies in the haemophilia population in Norway is among the lowest in Western E
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00162.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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10. |
Platelet aggregability and platelet volume in the postoperative course: Problems in the platelet aggregation test derived from the measurement of platelet volume |
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European Journal of Haematology,
Volume 39,
Issue 1,
1987,
Page 49-53
Shigehiro Morikawa,
Kaoru Kumada,
Kazutoshi Fujii,
Kiyoshi Fukui,
Keiichiro Mori,
Yusaku Okada,
Osamu Yoshida,
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摘要:
Platelet count, aggregability and volume in the postoperative course of 20 patients were examined. Platelet count was decreased on the 1st postoperative d, and increased on the 7th and 14th d compared with the preoperative value. The maximal aggregation rate of platelets induced by ADP was decreased on the 3rd postoperative d, and then recovered to the preoperative level. In contrast, platelet volume was only slightly increased on the 3rd postoperative d. In this study, there was no correlation between platelet aggregability and platelet volume in PRP. We have proposed one parameter, ‘platelet concentration ratio’ (platelet concentration in PRP/platelet concentration in whole blood). In the postoperative course, this concentration ratio changed depending on platelet volume, and possibly on other conditions of blood such as hematocrit, viscosity and specific gravity. The concentration ratio influenced the subpopulations of platelets in PRP. Platelet aggregation tests may be performed using PRP in which platelet subpopulations differ from those in whole blood, especially in the postoperative st
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1987.tb00163.x
出版商:Blackwell Publishing Ltd
年代:1987
数据来源: WILEY
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