摘要:

38 consecutive, previously untreated adult patients with acute non‐lymphocytic leukaemia (ANLL) were treated with BHAC‐AMP (N4‐behenoyl‐1‐β‐D‐arabinofuranosyl‐cytosine, aclacinomycin A, 6‐mercaptopurine, and prednisolone) therapy between March 1980 and February 1985. 25 patients (65.8%) achieved complete remission (CR). Median CR duration and median survival of patients who achieved CR were 14, and 24 months, respectively. The Kaplan‐Meier analysis revealed a probability for remaining in CR of 18.0% at 5 years. Analysis of failure cases revealed that most of them were due to resistant disease. Major toxicities were infection, diarrhoea, liver dysfunction, nausea and vomiting but these were acceptable. The results indicate that BHAC‐AMP therapy is comparable to the regimen with daunorubicin and cytosine arabinoside and a further clinical trial is necessary for previously untreated ad

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01243.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A factor VIII (FVIII) concentrate, virus‐inactivated by the solvent/detergent procedure, was studied in vitro. In contrast with most high‐purity, virus‐inactivated FVIII concentrates, it contains not only high levels of von Willebrand factor (vWF) antigen and ristocetin cofactor activity but also high molecular weight forms of von Willebrand factor. Furthermore, it is able to promote platelet adhesion on collagen in a perfusion system. In vivo studies performed in patients with different types of von Willebrand's disease provided evidence that this concentrate corrects Duke's bleeding time and prevents or stops haemorrhages. Thus, the particular advantages of this FVIII/vWF preparation are safety, low content of contamination proteins, and efficacy in von Willebrand's di

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01244.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Flow cytometric analysis of peripheral blood (PB) S + G2/M phase size was performed in 73 audit patients with untreated acute non‐lymphoblastic leukaemia, to assess whether the results may correlate to response rate and patient prognosis. All patients were treated with the same induction chemotherapy regimen: ARA‐C alone or in combination with an anthracycline antibiotic. Pretreatment PB S + G2/M phase size is significantly correlated to induction response rate (p<0.02), duration of response (p<0.02) and duration of survival. Patients with low PB S + G2/M phase size experience a longer survival, in patients over and below 50 yr (p<0.001). Lastly, early deaths tend to be more frequent in the high median age and high PB S + G2/M phase size group. Our study suggests that PB S + G2/M phase size has prognostic significance in obtaining response and duration of survi

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01245.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

In 42 patients with septic shock, 29 of whom underwent substitution with antithrombin III concentrate and fresh frozen plasma for coagulation disorders, the proteinase‐inhibitor complexes thrombin‐antithrombin III and neutrophil elastase‐alpha1proteinase inhibitor, were elevated on admission. On admission, the elastase complex was significantly higher in the patients receiving substitution (p = 0.0039), but at the endpoint it was higher in the non‐survivors (p = 0.0040). The elastase decrease was confined to the substitution group with the thrombin complex decreasing in both groups. Initially the thrombin complex correlated with prothrombin times and factor XIII, while the elastase complex correlated with creatinine, thrombocyte count and prothrombin times in the late stages. Hemostatic disturbance, thrombin generation and neutrophil elastase release were favorably influenced by substitution. Furthermore, in this uncontrolled pilot study, the survival rate was higher in the treated (16 of 29) than in the untreated (1 of 13) patients, although the treated patients initially had pronounced hemostatic distu

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01246.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Infectious mononucleosis may occasionally be complicated by purpura, but the mechanism of the thrombocytopenia is not known in detail. In the present study, 3 children with mononucleosis‐associated purpura were found to have marked elevations of platelet‐associated immunoglobulins and circulating platelet binding IgG and IgM. Employing electrophoretically (SDS‐PAGE) separated normal platelet membrane proteins in an immunoblot assay, serum IgG and IgM antibodies were found to be directed to antigenic determinants situated on glycoprotein GP IIb (140 kDa) in all patients, but also on smaller proteins of molecular weights between 30 and 52 kDa. 24 control sera were negative. Positive reactions were eliminated after absorption of sera with fresh platelets. These results demonstrate autoantibodies to platelet surface membrane proteins in infectious mononucleosis‐induced purpura and suggest a transient autoantibody‐mediated platelet destruction as the cause of thrombocytopenia in these

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01247.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The reactivity of a human monoclonal antibody directed against human B and T lymphocytes was tested for the first time at the ultrastructural level. The antigenic sites detected by this antibody were localized on the surface membrane of lymphocytes and, to a lesser extent, in the cytoplasm on membranes of the endoplasmic reticulum and perinuclear envelop of some centroblasts and immunoblasts. Ultrastructural demonstration of target antigen detected by human monoclonal antibodies may be important prior to therapeutic application of these antibodies.

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01248.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The percentage of pitted erythrocytes and Howell‐Jolly bodies in peripheral blood samples of 51 individuals following posttraumatic splenectomy and 20 patients splenectomized because of various haematological diseases differed significantly from each other (p<0.001) and from that of healthy controls (p<0.001). The percentage of pitted erythrocytes was significantly higher in pathologically shaped red blood cells (RBCs) (acanthocytes, schizocytes, elliptocytes) than in normal discoid shaped RBCs (p<0.001). As the number of pits per RBC showed great individual variations, a scoring system for the evaluation of pitted RBCs is propose

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01249.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Antibody response to pneumococcal vaccination was studied in 76 patients with Hodgkin's disease (HD) before, during and at different time intervals after cessation of therapy. All patients were in pathological stage I and II following explorative laparatomy with splenectomy. The increase in antibody response was compared to the findings in 12 healthy volunteers with the aim of establishing the optimal time for vaccination. Serum antibodies against 6 of the pneumococcal polysaccharide antigens (types 1, 4, 7F, 14, 18C and 23F) contained in the vaccine were determined by an ELISA. Antibody response to pneumococcal type antigens was similar in healthy adults and in patients with early stage HD before therapy. After treatment, post‐vaccination antibody response became negligible. Even up to 7 years after cessation of therapy patients were not able to raise a significant antibody respons

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01250.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

This paper studies relations of 21 HLA antigens of the A and B loci to selected characteristics in a group of patients with Hodgkin's disease. The investigated characteristics are age, sex, histological patterns, clinical stage and symptomatology. The considered group consists of 68 patients, 37 males and 31 females aged from 19 to 66 years and from 26 to 63 yr, respectively. A comparison between antigen frequencies for patients and controls (301 unrelated blood donors) is carried out. The results confirm that there is no relation between HLA antigens and Hodgkin's disease. A significant increase of All is found for females under 40 yr. Certain HLA antigens show significant correlation neither with the patient age nor with clinical or histological stages. A significant increase of B5 is observed for 16 relapsed patients. For them, significant test characteristics are found in the presence of cross‐reacting HLA‐B5,

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01251.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

86 previously untreated patients with multiple myeloma stage III entered a randomized trial comparing combination chemotherapy (VMCP/VBAP) (n = 42) with intermittent oral melphalan and prednisone (MP) treatment (n = 44). The treatment gropus were well comparable with regard to major prognostic factors. There was no statistically significant difference in the response rates, 52% (VMCP/VBAP) vs 61% (MP); in the response duration times, median 19 months vs 22 months, or in the survival times, median 24 months vs 28 months. However, survival of patients older than 65 years was significantly shorter in the VMCP/VBAP group (median 15 months) compared to the MP group (median 23 months) (p = 0.03). No significant difference in non‐hematological or hematological toxicity was noted. The study further supports the notion that MP therapy should be used as primary standard treatment for patients with multiple myelom

ISSN:0902-4441    

DOI:10.1111/j.1600-0609.1989.tb01252.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY