ISSN:1053-8569    

DOI:10.1002/pds.2630040302

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

ISSN:1053-8569    

DOI:10.1002/pds.2630040303

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

ISSN:1053-8569    

DOI:10.1002/pds.2630040304

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

摘要:

AbstractPharmacovigilance started in Italy in 1965, and from 1987 reporting of ADRs has been mandatory. Doctors have to send the filled forms on suspected ADRs to the Local Health Districts which transmit biannually all the reports to the Health Department.In a Northern Italian Region (Veneto) spontaneous reporting of adverse drug reactions (ADRs) has been studied during the period 1988–1993. This Region contributes a substantial percentage of the total Italian reports. The total number of reports was 3700, most of these (54 per cent) coming from GPs. A great variability in the reporting rate among the 36 districts of Veneto Region (range: 0–8.8 per 10,000 inhabitants per year) and an important under‐reporting have been evident. Underreporting is also emphasized by the fact that in 1993 the Veneto doctors who sent at least one report were only 2.7 per cent. On the whole about 35 per cent of reports concerned minor reactions caused by drugs which have a well known toxicological profile. Comparison between reports coming from Veneto and the UK in some cases show a similar safety profile (omeprazole and simvastatin), whereas in other cases (e.g. terfenadine, glafenine, fluoxetine) no correspondence can be found. This article reveals the limits of the actual spontaneous reporting in Italy and suggests some possible measures for improvi

ISSN:1053-8569    

DOI:10.1002/pds.2630040305

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

摘要:

AbstractA multicentre prospective investigation of the main treatment regimens for the Guillain‐Barré syndrome (GBS) was started in Italy to assess the quality of the care delivered for GBS in clinical practice. Between 14 April 1988 and 31 December 1993, 250 patients (157 males and 93 females aged 3 to 86 years) were recruited in 14 centres. The commonest treatments were plasma exchange (PE) (62 per cent), steroids (ST) (37 per cent) and immunoglobulins (IG) (19 per cent). Eighteen per cent of cases received ST and PE. These data contrast in part with reports on the treatment of GBS published between 1976 and 1993, which showed PE as an effective treatment, IG as a promising but still experimental drug, and ST as a failing therapeutic approach. The variables which seemed to affect the treatment choices most were centre, year of diagnosis, and disease severity. According to this survey, the treatment of GBS in Italy tends only partly to reflect the indications and recommendations in the main scientific reports. This not only indicates a suboptimal impact of the best available knowledge on the treatment of GBS, but also documents the need for more definite guidelines and further research through clinical tria

ISSN:1053-8569    

DOI:10.1002/pds.2630040306

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

摘要:

AbstractThis study was designed to survey drug prescribing for all patients over 65 years in institutional and hospital care in North and West Belfast, together with a home‐based sample, and to determine the influence of age, sex, mental score, functional score and place of abode on prescribing habits. Multiple regression analysis was used to analyse the effects of the various parameters on number of drugs received. Drugs were categorized into therapeutic classes and for each class a separate logistic regression analysis was performed to identify the variables which independently predicted receipt of that class.A total of 1094 people were surveyed with an average of 3.26 medications per person. The most common classes of drugs received were diuretics (39.8 per cent), analgesics (31.7 per cent), hypnotics (25.3 per cent), phenothiazines (21.7 per cent) and laxatives (20.9 per cent). Number of drugs received was not predicted by age or sex but by institutional or hospital placement. Placement was also the most significant independent predictor of drug class. Age, sex, mental and functional scores were less significant.Drug utilization in this representative elderly population seemed appropriate with low prescribing rates for some drug classes considered hazardous or ineffective in this age grou

ISSN:1053-8569    

DOI:10.1002/pds.2630040307

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

摘要:

AbstractMenstrual disturbances are not a generally recognized side‐effect of non‐steroidal antiinflammatory drugs (NSAIDs). Five case reports to the Netherlands Pharmacovigilance Foundation LAREB concern menstrual disturbances in suspected connection with the use of an NSAID. In one patient at several occasions the use of naproxen for dysmenorrhoea was followed by interruption of menstruation. In four other women the use of diclofenac, indomethacin or naproxen was followed by hypo‐ or amenorrhoea of one cycle duration. Prostaglandins play a complex role in the physiology of menstruation. The effects of NSAIDs on cyclo‐oxygenase and prostaglandin metabolism may explain the observed disturbances of menstruation. Female patients of child‐bearing age using an NSAID — either to treat dysmenorrhea or for other reasons — should be aware of the possibility of interruption, delay, decrease or missing of a men

ISSN:1053-8569    

DOI:10.1002/pds.2630040308

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

摘要:

AbstractThe importance of drug‐related problems as a cause of hospital admissions in Hong Kong was studied in 925 patients admitted to two general medical wards at the Prince of Wales Hospital between November 1992 and February 1993. Drug‐related problems were judged to be the main reason for hospital admissions in 88 patients (9.5 per cent). These were adverse drug reactions (n= 57), drug poisoning (n= 22) and treatment failure consequent to noncompliance or inappropriate reduction in dosage (n= 9). The most important adverse drug reactions were gastrointestinal hemorrhage (36.8 per cent) and hypoglycemia (24.6 per cent), and the three drug classes that were most commonly involved were non‐steroidal anti‐inflammatory drugs (NSAIDs) (aspirin 12.3 per cent, non‐aspirin 28.1 per cent), sulphonylureas (19.3 per cent) and diuretics (12.3 per cent). Drug‐related problems are an important cause of hospital admissions, and much of the drug‐induced illnesses in Hong Kong could be preventable if particular attention was given to NSAID and sulphonylurea therapy. Patients should also be educated about the importance of good dr

ISSN:1053-8569    

DOI:10.1002/pds.2630040309

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

摘要:

AbstractThe purpose of this study was to determine the frequency and pattern of histamine H2‐receptor antagonist drug use in an ambulatory elderly population of individuals over 65 years of age from 1978 to 1992. A longitudinal health screening programme of ambulatory elderly participants was employed to conduct a series of cross‐sectional studies over a 14‐year period.Participants in the first period (1978–79) included 855 (37.1%) men and 1448 (62.9%) women. The use of histamine H2‐receptor antagonist increased from 0.8% of the population in the 1978–79 period to 7.0% in the 1991–92 period. There was no statistically significant correlation between drug use and age (p = 0.8114) or sex (p = 0.9229) at the 1991–92 time period. In the 1991–92 time period, cimetidine and ranitidine combined, accounted for 86.0% of all reported histamine H2‐receptor antagonist.Over the 14‐year period of study there has been a nearly constant increase of histamine H2‐receptor antagonist use in

ISSN:1053-8569    

DOI:10.1002/pds.2630040310

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

ISSN:1053-8569    

DOI:10.1002/pds.2630040311

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY