摘要:

AbstractThe aim of this study was to try to place gastric intestinal metaplasia, type III (type III IM) in the stepwise chain of events from atrophic gastritis to cancer. A number of dysplastic, periulcer regenerative, and type III IM lesions were qualitatively diagnosed (and graded) blindly and independently by several pathologists. These lesions were further analysed by means of quantitative parameters, with the aim of differentiating dysplastic from regenerative changes. Inconsistencies between the qualitative and quantitative classification (about 7 per cent of cases) were eliminated and homogeneous groups (low‐grade dysplasia, high‐grade dysplasia, regenerative changes) were obtained. These cases were taken as the gold standard against which type III IM was compared. The results indicate that the great majority (91·4 per cent) of cases of type III IM fulfil the nuclear and architectural criteria for low‐grade dys

ISSN:0022-3417    

DOI:10.1002/path.1711690112

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

摘要:

AbstractA series of 83 rectal biopsies was examined by electron microscopy (EM), 78 from HIV‐seropositive patients (64 with diarrhoea, 9 with weight loss, and 5 asymptomatic) and 5 from controls without risk factors for HIV infection. Although EM identified the likely cause of the diarrhoea in only nine cases, the majority of symptomatic HIV‐seropositive patients had abnormal biopsies including the presence of tubuloreticular structures, loss of microvilli, and oedema and disruption of autonomic nerves. Neuronal abnormalities were particularly common in patients with cryptosporidiosis, but no ultrastructural marker was specific to ‘pathogen‐negative’

ISSN:0022-3417    

DOI:10.1002/path.1711690113

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

摘要:

AbstractTumour invasion in the central nervous system (CNS) was studied using a mouse melanoma cell model. Attention was concentrated on the third ventricle as this site is distant from any implantation artefact. Transmission electron microscopy (TEM) revealed the formation of tumour cell aggregates within the ventricle. Underlying ependymal cells showed loss of cilia and microvilli. Progressive thinning of the ependymal cells took place until continuity of the ependyma was lost through ependymal retraction. Tumour cells were then in direct contact with sub‐ependymal neuroglial processes. Further invasion was then accomplished by penetration between neuropil processes, followed by tumour cell infiltration along the intact basement membrane of cerebral capillaries with displacement of astrocyte foot processes from the capillary basement membran

ISSN:0022-3417    

DOI:10.1002/path.1711690114

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

摘要:

AbstractTwo doses of adriamycin (2 mg/kg i.v.) were administered to young adult rats with a 22‐day interval and the kidneys were examined 51, 79, and 107 days after the first injection. Light microscopy showed early prominent intraglomerular microcystic spaces and progressive, though not severe, segmental glomerulosclerosis with focal interstitial scarring and round‐cell infiltration. The main features of the ultrastructure were widespread fusion of foot processes, focal cytoplasmic rarefaction of podocytes, and non‐specific sclerosis of the mesangium without signs of severe degenerative changes or mesangiolysis. The Segmental microcystic structures corresponded to agglomerted intrapodocytic vacuoles. The scatter of glomerular polyanion sites visualized by polyethylenimine–phosphotungstic acid resembled that of control animals but the quantitative assessment revealed a significant reduction. CD4‐positive cells were the predominant element of the interstitial infiltrates. Most of the infiltrating cells expressed Ia antigens, whereas la‐positive intraglomerular resident mononuclear cells were depleted. The adriamycin lesion resembles the post‐five‐sixths nephrectomy ablation nephropathy in the subpopulations of the interstitial infiltrate but differs from it in the reduction of intraglomerular resident macrophages, the absence of destructive mesangial damage, and reduced segmental glomerulosclerosis. The main feature is the prolonged damage of podocytes, especially of their cyto

ISSN:0022-3417    

DOI:10.1002/path.1711690115

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711690116

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711690119

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711690120

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711690121

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711690122

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711690101

出版商:John Wiley&Sons, Ltd.    

年代:1993

数据来源: WILEY