摘要:

AbstractA characterisation of the biological behaviour of gastric carcinoma was attempted by relating the histological classification to the mean number of metastases for each case (metastatic index). The material was chosen from a consecutive series of 294 gastric cancer autopsies in which only conservative therapy had been given or in which the cancer was first diagnosed at autopsy.According to the extent of metastasis it was possible to divide the nine histological types into two groups of limited invasiveness and generalised invasiveness. Unfavourable biological behaviour of the cancer was determined by the presence of the latter group of histological types in the primary site even in cases where this histological type formed the minor component of the tumour. The variation in histology within the primary tumour and between the primary site and the metastatic sites was related both to histological affinities and to the metastatic index associated with the primary site histology. It is suggested that this dual classification system adds significantly to our understanding of the natural history of gastric cancer.

ISSN:0022-3417    

DOI:10.1002/path.1711340202

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractMethods used in the study of human mononuclear phagocytes in vitro were applied to surgical specimens from 49 patients with non‐Hodgkin lymphomas and eight patients with hairy cell leukaemia.Two of the tumours (both classified as “true histiocytic” neoplasms by the Kiel criteria) were distinguished by the presence of atypical macrophages in thein vitrosystem. In one the atypical cells were adherent; In the other example they were non‐adherent. These tumours were the only examples of mononuclear phagocyte neoplasia identified in this series. All the remaining 47 cases of non‐Hodgkin lymphoma were judged to be of lymphoid origin.While initial observations on hairy cell leukaemia‐derived spleen cells suggested macrophage neoplasia, this impression does not stand up to more detailed analysis. The findings are more in keeping with a B lymphoid cell lineage.In hairy cell leukaemias and low grade lymphoma the proportion of macrophages per gram weight of tissue is diminished. This suggests a deficiency of macrophage functional activity compared with normal; the nature of this defect i

ISSN:0022-3417    

DOI:10.1002/path.1711340203

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractRound glass coverslips were implanted in the subcutaneous tissue of mice previously immunized to sheep red cells (SRBC) and the same antigen injected into the pocket where the coverslip lay. It was shown that when mice received a prior dose of cyclophosphamide (Cy) the number of macrophages adherent to the glass increased, they showed more pre‐mitotic DNA synthesis and were more phagocytic via their Fc and C3b surface receptors. However, when BCG was inoculated into similar coverslip pockets in mice not previously sensitized to BCG but pre‐treated with Cy, the number of macrophages on the glass surface fell and their phagocytic potential decreased compared with non‐Cy‐treated controls.When BCG was inoculated into the peritoneal cavity of mice, Cy treatment induced a significant increase in the number of lesions in the peritoneal cavity compared with non‐Cy‐treated controls. When BCG was injected into the footpad of mice it was clear that pre‐treatment with Cy abolished the increase in foot volume otherwise seen at 24 hr but led to a sustained increase in volume which reached a peak on day 6. However, when Cy was given to the mice 5 days after BCG injection the course of the response was not altered.It is concluded that treatment with Cy before an inflammatory stimulus with an immunological component, modifies macrophage function and granuloma development. Differential effects of Cy on various components of the immune response are thought to be its most likel

ISSN:0022-3417    

DOI:10.1002/path.1711340204

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractWe have attempted to verify the suggestion that synovial membrane is the result of mechanical disruption of connective tissue, and may occur at any site. Mechanical disruption of the subcutaneous connective tissue was achieved in rats and mice by the repeated injection of air. The resulting cavities developed a lining structure with many of the features of synovial membrane as judged by electron microscopy, and light microscopy using haematoxylin and eosin and van Gieson stains, esterase activity and immunofluorescent staining for Ia antigen. A structure closely resembling synovium is formed as early as 6 days, providing a convenient method for studying large quantities of facsimile synovial tissue under a wide variety of easily administered stimuli.

ISSN:0022-3417    

DOI:10.1002/path.1711340205

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractA histochemical study has been done on a group of 18 hepatocarcinomas induced by aflatoxin. One hundred per cent. incidence of hepatocarcinomas is induced by feeding 5 p.p.m. aflatoxin for 6 weeks. The carcinomas were trabecular hepatocarcinomas with a mixed adenomatous pattern and showed considerable variation in histochemical reactions throughout the lesions. There was a patohy distribution of glycogen and glucose‐6‐phosphatase and the membrane ATPase was present along much of the canalicular border of the cells but with an abnormal and tortuous pattern. Aniline hydroxylase was present in varying amounts in both trabecular and adenomatous carcinomas. It is concluded that the histological variants of hepatocarcinoma are all derived from hepatocytes, but no unique changes were observed related to the progress involved in malignant neoplasia. The observations form a basis for comparison with early lesions seen prior to the recognition of carcin

ISSN:0022-3417    

DOI:10.1002/path.1711340206

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711340207

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711340201

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY