摘要:

AbstractPart of the rectum of the female Wistar rat was X‐irradiated (1500 rad–3000 rad) without surgery. In the early phase (second week after irradiation) radiation damage of the rectum was haemorrhagic radiation proctitis and in the late phase a rectal obstruction. The dose‐effect relationship using rectal obstruction as the end point is a sigmoid curve with a LD50 of 2150 rad. Latency time decreases with increasing dose and is 150 days at the LD50. Histopathologic findings revealed excessive submucosal radiation fibrosis and numerous mucosal glands and cysts within the fibrotic submucosa. As the time after irradiation increased the extension of submucosal mucinous glands increased and sometimes the entire submucosa was replaced completely by mucosal glands and cysts. It is suggested that invasion of mucosal epithelium into the submucosa was allowed by manifold fragmentation of the muscularis mucosae due to lymphocysts having developed immediately after irradiation. The small arteries showed proliferation of the endothelium and adventitia, thickening and hyalinization of the wall, resulting in severe narrowing and even occlusion of the

ISSN:0022-3417    

DOI:10.1002/path.1711380302

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe structure of the arteries which supply blood to the carotid bodies was examined in five cases in which the weights of the cardiac ventricles were normal and in which hypoxaemia due to emphysema or systemic hypertension were absent. The right glomic arteries were studied by light microscopy, and the left by electron microscopy. A sixth case, also free from myocardial hypertrophy, was used solely for an examination of the common carotid artery, the carotid sinus and the internal carotid artery by light and electron microscopy. The glomic arteries resembled the carotid sinus in being highly elastic with a rich supply of non‐myelinated nerve fibres and thus had a structure consistent with having a baroreceptor functio

ISSN:0022-3417    

DOI:10.1002/path.1711380303

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA study was made of mycobacterial‐induced granulomas in guinea‐pig lymph nodes. Live BCG (Pasteur) induced a granuloma containing epithelioid cells while Cobalt irradiatedMycobacterium lepraeinduced a granuloma comprised of phagocytic macrophages. The granulomas were quantitated by measurement of lymph node weight and the areas of infiltration in histological sections. The time course of granuloma formation induced by Co‐irradiatedM. lepraewas very different from the time course of the granuloma formation induced by BCG. Collagen synthesis assessed by incorporation of14C‐proline into collagenase sensitive protein was greater in lymph nodes draining the site of injection of Co‐irradiated BCG than those draining the site of injection of Co‐irradiatedM. lepraeduring the first 10 weeks. Collagen synthesis was delayed in the nodes from animals injected with live BCG for at least 10 weeks. Single cell suspensions of draining lymph nodes containing granulomas consisted of lymphocytes and large cells (epithelioid cells and macrophages). A high proportion of the large cells were found to be non‐adherent in the live BCG‐induced epithelioid cell granuloma. In contrast,M. leprae‐induced granulomas contained a high percentage of adherent large cells. In both the granulomas, the majority of large cells were esterase positive and showed the presence of fibronectin. Most of the large cells in the granulomas did not carry receptors for the Fc component of IgG or the C3 component of complement and did not exhibit pe

ISSN:0022-3417    

DOI:10.1002/path.1711380304

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractWe describe the pathological findings in a case of tracheopathia osteoplastica (TPO) of minimal extent. Although described clinically such minimal lesions have not been previously studied pathologically. Our observations lend strong support to the view‐point that the nodules of TPO develop as ecchondroses of the tracheal cartilage rings. It is anticipated that TPO of minimal extent will be increasingly identified clinically and diagnosed on biopsy specimen

ISSN:0022-3417    

DOI:10.1002/path.1711380305

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractRecent advances in immunology have revealed that the “histiocytic” lymphoma of Rappaport is a proliferation of transformed lymphocytes rather than true histiocytes, and that the malignant cells in malignant histiocytosis (MH) are truly transformed histiocytes. We previously reported cases of MH presenting as lethal midline granuloma (MH‐LMG) utilising fresh tissue specimens for the detection of cytological markers in a small number of cases. The results showed the true histiocytic nature of the proliferating cells. In this study, paraffin‐embedded specimens from 16 cases with MH‐LMG were processed for immunoperoxidase procedures to confirm the true histiocytic nature of the proliferating cells. Five cases with nasal and paranasal lymphomas (ML) were also stained to test the usefulness of immunoperoxidase procedures for distinguishing the MH‐LMG from ML. Results were as follows; proliferating cells in MH‐LMG were histiocytic in nature, staining positive for lysozyme in MH‐LMG in contrast to the negative

ISSN:0022-3417    

DOI:10.1002/path.1711380306

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractDental amalgam, either in the form of a solid rod or as a fine powder was implanted subcutaneously into guinea‐pigs and the tissue reactions were examined after varying time periods. The solid rods were enclosed by fibrous capsules within which only extremely limited breakdown occurred. This appears to result from electrolytic corrosion of the γ2(SnHg) phase of the rod's surface. Powdered amalgam induced granulomata and most of the particles of amalgam were actively digested by macrophages and giant cells. This resulted in the progressive loss of mercury and tin from the lesion and the formation of minute particles containing silver and sulphur which became widely distributed throughout the lesion, being associated with basal lamina, collagen and elastic tissue and giving rise to the formation of a tattoo. In contrast, some particles of amalgam, too large to be interiorised. were encapsulated by collagen and persisted almost unchanged. Intracellular small amalgam particles and aggregates of fine particles, resulting from their degradation, were seen within lymph node macrophages. It is extremely likely that the sequence of events leading to the formation of an amalgam tattoo of the oral mucosa in Man are the sa

ISSN:0022-3417    

DOI:10.1002/path.1711380307

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe cellular responses in the lymph nodes, thymus and liver of mice infected withTrypanosoma congolensewere examined and considered in relation to changes in the level of Ig in the serum. A significant proliferative response occurred in the lymph nodes only after 3 weeks of infection and involved mainly the B‐dependent folliçular areas in which there was marked germinal centre formation. This was associated with the appearance in the medullary cords of large numbers of plasma cells. Only a minor increase in the number of macrophages was observed in the lymph node sinuses and there was no obvious lymphoid depletion. A partial depletion of the cortical areas of the thymus in the later stages of the infection was the only remarkable feature in that organ. An abrupt but transient increase in the levels of the 4 classes of Ig which were monitored was observed about the time of the first peak of parasitaemia and was considered to result from the proliferative response in the spleen. A second and more pronounced increase occurred later coinciding with the onset of proliferative activity in the lymph nodes. There was marked cellular infiltration into the liver; this commenced about the time of the first peak of parasitaemia when it involved mainly lymphocytes and plasma cells and became progressively more severe involving a mixture of cell types including lymphocytes, plasma cells and erythropoietic and granulopoietic cells. In addition, there was an increase in the number of Kupffer cells lining hepatic sinusoids. Throughout most of the infection, focal hepatic necrosis and increased mitotic activity of hepatocytes were prominent features. The differences in timing and character of the cellular responses between the different lymphoid organs were considered to be due in part to the restriction ofT. congolenseto the intravascular spac

ISSN:0022-3417    

DOI:10.1002/path.1711380308

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711380301

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY