ISSN:0022-3417    

DOI:10.1002/path.1711560102

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711560103

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711560104

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractIn a combined retrospective and prospective study, clinical and autopsy data were collected to assess the changes in autopsy rate in recent years, the attitudes of clinicians and pathologists to the autopsy, and the accuracy of ante‐mortem diagnosis when compared with autopsy findings. Between 1962 and 1986, the total autopsy rate for hospital patients remained relatively constant, with an increase in Coroner's and a decrease in the hospital autopsy rate. Analysis of 5064 deaths over a 6‐year period showed a significantly greater number of males than females coming to autopsy and a decrease in autopsy rate with age for both sexes.Attitudes to the autopsy were assessed using a questionnaire. The majority of clinicians considered the autopsy to be an important investigation despite new diagnostic techniques and confirmed its value in teaching and research. Seventyseven per cent agreed that autopsy findings occasionally led to modification of the treatment of subsequent patients with the same condition. Pathologists disagreed that the autopsy is outdated in its present form and considered that not enough hospital autopsies are being requested. They also upheld its use and value in education. The cause of death as given by clinicians for a group of 60 patients was inaccurate in 12 ca

ISSN:0022-3417    

DOI:10.1002/path.1711560105

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractIn this study, alcohol‐induced histological lesions in a short‐term experimental rat model were compared with those characteristic of human alcoholic liver disease. In the rat model used, pretreatment with carbon tetrachloride (CCl4) for 6 weeks was employed possibly to sensitize the liver for the effects of alcohol and shorten the time of induction of alcoholic liver disease. After 6 weeks of CCl4treatment, subsequent maintenance on drinking water containing up to 10 per cent alcohol for 7 weeks potentiated liver fibroplasia as compared with non‐alcohol‐treated rats. However, steatosis and alcoholic hepatitis, as histological evidence for alcoholic liver disease as seen in humans, were not observed. In non‐CCl4‐pretreated control animals, alcohol administration had no effect on liver histology.It can be concluded that in the model used, CCl4pretreatment sensitizes the liver to increase collagen deposition following alcohol administration, but not to steatosis or alcoholic hepatitis as seen in human alcoholic liver disease. In this experimental set‐up, direct metabolic interaction of CCl4with alcohol as a cause of the increased fibroplasia ca

ISSN:0022-3417    

DOI:10.1002/path.1711560106

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractTrichosporon beigeliiis a normal inhabitant of soil and is occasionally found as normal flora of the skin and mouth. Opportunistic infection by this fungus has been increasingly reported in immunocompromised patients. The diagnosis of this infection depends on positive cultures or histological evidence. However, it is sometimes difficult to distinguish this fungus fromCandidaspecies in tissue section. We have generated two monoclonal antibodies that can distinguishT. beigeliifrom other fungi including several species ofCandida. One of these antibodies (K‐16) reacts withT. beigeliiin formalin‐fixed, paraffin‐embedded tissue sections and will be useful as an aid to the accurate diagnosis of trichosporo

ISSN:0022-3417    

DOI:10.1002/path.1711560107

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractThe present work was carried out to look for the ultrastructural substrate of the contact zones between Langerhans cells and lymphocytes. A high resolution electron microscopic analysis of the contact zones between Langerhans cells and lymphocytes was performed. The material used for this study was obtained from experimental contact dermatitis in mice, and human cervical squamous carcinoma and mycosis fungoides. Three types of cell—cell binding were found. Type I is a junction‐like structure characterized by the presence of intercellular bridges. It is suggested that this contact might represent a fixation mechanism between the two cells. Type II is characterized by a glycocalyx—glycocalyx continuity. An immunological function—recognition and antigen presentation—is proposed for this type of contact. Type III is a septilaminar tight contact area which seems to be a gap junction.It is suggested that all these types of physical contact might be the morphological expression of interaction between antigen presenting cells and ly

ISSN:0022-3417    

DOI:10.1002/path.1711560108

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractFourteen cases of a benign lesion of the breast, often referred to as ‘lactating’ adenoma, are described. They were all first noticed during pregnancy. The microscopic changes are similar to those seen in the normal pregnant breast but vary in degree and are out of phase with it. Any association with fibroadenoma or fibrocystic disease seems coincidental. ‘Lactating’ adenomas are also clearly distinguishable from tubular adenomas, which consist of masses of closely set tubules, like ductules of the normal resting breast, and are not related to pregnancy. Immunocytochemistry using antisera to breast and tumour associated antigens can demonstrate clear differences between ‘lactating’ adenoma, other breast lesions, and the normal pregnant breast. A plea is made for the designation of these lesions as ‘breast tumour of pregnancy’ as they do not arise in the l

ISSN:0022-3417    

DOI:10.1002/path.1711560109

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractTwenty‐four male breast lesions including ten normal, ten gynaecomastia, and four infiltrating carcinomas were studied for the presence and distribution of lectin binding carbohydrates. For comparison, tissue sections of five normal female breast lesions, ten each of fibrocystic disease, fibroadenoma, and carcinoma, were also included in this study. Formalin‐fixed, paraffin‐embedded tissues were tested withGlycine maximus(SBA),Dolichos biflorus(DBA),Triticum vulgaris(WGA),Concanavalia ensiformis(Con A),Lotus tetragonolobus(LTA),Arachis hypogaea(PNA), andBandeiraea simplicifolia(BSAI). The lectin‐binding patterns were similar in normal, gynaecomastia, and carcinoma, and were not pathognomonic to any male breast lesion. These lectin reactive patterns in the male breast appear to be similar to those reported for the female breast

ISSN:0022-3417    

DOI:10.1002/path.1711560110

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractA case is reported of a 66‐year‐old female with an extraskeletal myxoid chondrosarcoma which had originated in the lateral region of the right knee. The tumour tissue of the primary, recurrent, and metastatic deposits in the lungs was examined by electron microscopy and immunohistochemistry. Almost all the sarcoma cells in every tumour specimen harboured immunoreactivity to botha‐ and β‐subunits of S‐100 protein. A large population of cells in the subcutaneous tumour at autopsy had numerous parallel arrays of microtubules within the rough endoplasmic reticulum in addition to the well‐described ultrastructural features indicative of chondroblastic origin. These structures were present in round to polygonal, but not in fibroblastic, tumour cells. Tubulin immunoreactivity in the tumour cells showed the same tendency, being frequently positive in the large cells of the subcutaneous tumour but weakly positive in the fibroblastic and medium‐sized cells of the recurrent and metastatic tumours. The parallel arrays of intracisternal microtubules therefore may be composed of tubulin protein, as in ordinary cytoplasmi

ISSN:0022-3417    

DOI:10.1002/path.1711560111

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY