摘要:

AbstractA human malignant Schwannoma was serially transplanted through three generations in nude mice. The tumours grew readily and the take‐up rate was 100 per cent. No metastasis was observed in nude mice. Morphological features of the original tumour were strictly maintained through all the transplant generations. The tumour cells of the original and of the transplants showed features of primitive Schwann cells of embryonic nerve trunk

ISSN:0022-3417    

DOI:10.1002/path.1711350302

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractCarbon tetrachloride inhalation in phenobarbitone‐treated rats caused a rapid rise in hepatic prolyl hydroxylase activity which was followed by an increase in hepatic collagen and free proline concentrations. Colchicine in a dose of 5 μg/day largely prevented the increase in hepatic collagen. This effect was not mediated by impairment of prolyl hydroxylase activity. Colchicine is of potential therapeutic value in preventing the progression of chronic liver disease to cirrhos

ISSN:0022-3417    

DOI:10.1002/path.1711350303

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe lining of five branchial cysts from patients aged from 17 to 51 was studied by histochemical methods for non‐specific acid esterase and acid phosphatase and by scanning and transmission electron microscopy. The stratified squamous epithelium was shown to be a specialised structure, with a few microvillous cells on the surface and an intra‐epithelial network of channels containing lymphocytes, notably T cells, and mononuclear phagocytic cells. The appearance of the cyst lining was similar to that of the epithelium lining the crypts of palatine tonsils. The demonstration of a complex lympho‐epithelial lining of the cysts does not settle the controversial question of their origin, but it must be taken into account by hypotheses explaining the development of branchial

ISSN:0022-3417    

DOI:10.1002/path.1711350304

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractCharacteristic ultrastructural alterations of the glomerular basal lamina have been reported in hereditary nephritis. The basal lamina is irregularly thickened and the lamina densa shows replication with a “basket weave” pattern, enclosing electron‐lucent lacunae which frequently contain small dense particles. However there is controversy regarding the specificity of this lesion in hereditary nephritis. To determine the specificity, 366 renal biopsies from 310 children were studied retrospectively. Twenty‐four out of 27 patients with hereditary nephritis showed the characteristic changes of the basal lamina and they were widespread in 17.Two patients with recurrent haematuria but no family history of deafness or haematuria showed similar extensive changes and are regarded as new mutant cases of hereditary nephritis.Similar changes were seen in 17 of the 281 patients with other conditions but were always localized to a few capillary loops. We conclude that a widespread “basket weave” pattern appears to be confined to hereditary nephritis and is seen in the great majority of

ISSN:0022-3417    

DOI:10.1002/path.1711350305

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractExtracellular curved striated bodies and round bodies were found in 62 and 41 per cent. respectively of 360 renal biopsies performed in children with a variety of nephropathies. They were observed in the basal lamina and mesangial matrix. The fact that they commonly occurred together appears to suggest a common aetiology and they are probably derived from altered protein of the basal lamina and mesangial matrix, or from proteins of immune deposits.

ISSN:0022-3417    

DOI:10.1002/path.1711350306

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe pancreas was examined histologically in 146 cases of patients dying of shock. The finding of morphological evidence of disseminated intravascular coagulation (DIC) in the pancreas supports the opinion that the pancreas is highly sensitive to disturbances of blood perfusion.The presence of DIC combined with a variety of pathological lesions in the exocrine and endocrine pancreas was sufficiently characteristic to justify use of the term “shock pancreatitis”.The relative scarcity of data hitherto available on pathological changes in the pancreas caused by shock can be ascribed to changes in the management of shock. It is concluded that the pancreatic lesions described in this study could influence the outcome in shock treated by modern methods of resuscitat

ISSN:0022-3417    

DOI:10.1002/path.1711350307

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractA cytochemical method has been used to demonstrate oestrogen receptor in histological sections of breast carcinomas, and has given similar qualitative results to the biochemical dextran‐coated charcoal method. Two conjugation techniques were employed to couple horseradish peroxidase to 17β‐oestradiol‐6‐O‐carboxymethyloxime—bovine serum albumin. The periodate conjugation method led to a greater degree of coupling but a higher concentration was required for demonstration of oestrogen receptor than that needed when the two‐stage glutaraldehyde conjugation method was used, even though this resulted in a lesser degree of coupling.Care in the preparation of tissue has been found to be essential. Formalin‐fixed, paraffin‐embedded tissue was unsuitable; rapid freezing of fresh tissue, only brief air‐drying or acetone fixation of tissue sections and short‐term storage were important.A correlation has been shown between the presence of oestrogen receptor in breast carcinomas and good histological differentiation. The poorer differentiated tumours were also found to contai

ISSN:0022-3417    

DOI:10.1002/path.1711350308

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711350301

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY