ISSN:0022-3417    

DOI:10.1002/path.1711430202

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe microscopical features in specimens of liver tissue from 14 patients considered to be suffering from Diffuse Nodular Hyperplasia (DNH) were compared with the changes found in livers from five other groups of patients. The diagnoses in these groups were macronodular cirrhosis, hepatic venous occlusion, congestive cardiac failure, compensatory hyperplasia after destruction of part of the liver and chronic biliary disease respectively. In all these groups the formation of thick hepatocyte plates, thought to represent cell proliferation, was a constant and striking feature. Such plate thickening in the periportal regions was associated with congestive cardiac failure and with hepatic venous occlusion. The diffuse involvement of almost all plates formed part of the changes in DNH, cirrhosis, compensatory hyperplasia and chronic biliary disease. Normal vascular relations were retained in the patients with compensatory hyperplasia and chronic biliary disease and lost in cirrhosis and, in some parts, in DNH. The nodules were small in DNH and larger in cirrhosis, where they were surrounded by fibrous tissue. DNH appeared to be recognizable in needle biopsy specimens.

ISSN:0022-3417    

DOI:10.1002/path.1711430203

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe consequences of acute inflammatory damage and chronic repair in the conducting system of the canine heart were observed after experimentalTrypanosoma cruziinfection of young dogs. Acute infection lasted for 18–25 days and caused hyaline and lytic necrosis of the atrio‐ventricular conducting fibres, the sinus node and the neurons in the cardiac para‐sympathetic ganglia. Dogs that survived acute disease were examined after periods from 8 months to 3 years. Three main types of healing were found in the conducting system: fibrosis (diffuse and/or focal), sclero‐atrophy and fatty infiltration. No signs of active chronic inflammation were present, although small focal residual accumulations of mononuclear cells were present in some animals. No evident electrocardiographic alterations were elicited by the presence of such cicatricial lesions. The animal model appears worthwhile for the study of the healing process in conducting tissue of the heart and for the better understanding of the asymptomatic phase ofT. cruziinfection

ISSN:0022-3417    

DOI:10.1002/path.1711430204

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe effects of x‐irradiation on the subcellular structure of the human urinary bladder were investigated by electron microscopic examination of biopsies taken during check cystoscopies from 25 patients between 1 month and 22 years after completion of a course of therapeutic radiation. All tissues of the bladder wall were damaged to some extent by the treatment. In the urothelium this was reflected by the development of more than the usual numbers of lysosomes and autophagic vacuoles in all cell layers. In the bladder wall, large often binucleate or multinucleate fibroblasts were prominent and persistent in all specimens and were associated with the development of progressive fibrosis. The vasculature and the muscle coats of the bladder wall were also damaged. In the blood vessels many endothelial cells were oedematous or necrotic and some intravascular coagulation was also observed. Smooth muscle cells became oedematous soon after irradiation, and after longer time intervals there was focal death and loss of individual muscle cells. The observed degeneration and extensive necrosis of the bladdet wall, which involved severe destruction and disorganization of the muscular layers, is sufficient to explain the clinical sequelae of bladder irradiation, namely loss of elasticity, reduced capacity and incomplete micturition with residual urin

ISSN:0022-3417    

DOI:10.1002/path.1711430205

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe pulmonary response to the deposition of carbon particles was investigated to determine the routes of cellular efflux and the mechanisms of particulate clearance. At intervals to 6 months after the intratracheal instillation of 4 mg carbon, the lungs of mice were fixedin situby perfusion without lavage. Within a few hours, migration of granulocytes into the bronchioles was observed; large numbers of PMNs were not seen in alveoli until 24 h. Associated with the PMN efflux there was transient oedema with no evidence of pulmonary cell necrosis. The number of free macrophages increased in response to the carbon and mononuclear cell migration into alveoli and bronchioles was also observed. The bronchiolar component of the cellular efflux indicates that PMNs and macrophages recovered from the lung by lavage are not entirely of alveolar origin. Whereas most particles, either free or in phagocytic cells, were cleared by the bronchial tree, some transepithelial passage of free particles to the interstitium was observed. Some carbon was found in hilar lymph nodes but overall lymphatic clearance was low.

ISSN:0022-3417    

DOI:10.1002/path.1711430206

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe sequential and dose‐dependent effects ofO,O,S‐trimethyl phosphorothioate (OOS‐Me) on rat lung bronchiolar epithelium were investigated using scanning electron microscopy. At 12 h after oral treatment (20 mg/kg), there was a small increase in debris in the bronchioles and, by 24 h, there was much debris as well as phagocytic cells in the bronchioles. After 3 days, there was a decrease in the number of bronchiolar Clara cells as determined by the loss of their characteristic apical bulges. Concomitanty there was a significant increase in lactate dehydrogenase activity in bronchopulmonary lavage fluid. By day 7, the Clara cells appeared to be reforming and, by day 14, the morphology of bronchiolar epithelium had returned to normal. Dose‐dependent studies revealed a threshold dose level of OOS‐Me between 10 and 20 mg/kg which produced the observed effects in Clara cells. Both sequential and dose‐dependent effects of OOS‐Me on Clara cells were correlated with changes in bronchopulmonary lavage lactate dehydroge

ISSN:0022-3417    

DOI:10.1002/path.1711430207

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711430210

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711430213

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711430216

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711430218

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY