摘要:

AbstractThe percentage of peritoneal macrophages synthesising DNA in the unstimulated mouse peritoneum was found to be 0.4 per cent. after a 30 min in‐vivo pulse label of3H Tdr. This percentage was found to rise to 4.0, 24 hr after stimulation of the cavity with thioglycollate. Using BrdU incorporation as an indicator of DNA synthesis it was found that in the unstimulated animals S + G2lasted 12–15 hr while the same functions in stimulated animals took 7–10 hr. A small proportion of much more rapidly dividing cells was found in both stimulated and unstimulated animals. These findings possibly reflect differences between resident and exudate macrophages, or alterations in the kinetics of macrophage division as a result of inflammation. It was concluded that as the increase in the number of cells synthesising DNA and their rate of division was too low, the increase in the number of cells in the stimulated cavity could not be solely the result of cell division within the c

ISSN:0022-3417    

DOI:10.1002/path.1711330302

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractMitral valves from ten patients with spontaneous rupture of mitral chordae were examined by light, scanning and transmission electron microscopy. Changes identified at rupture sites included oedema and necrosis of collagen, endothelial loss and, in some cases, partial or complete re‐endothelialisation of the disrupted ends. With a solitary exception these abnormalities were confined to chordae which had actually ruptured. Some nonruptured chordae were irregularly thinned and stretched but were normal by light and electron microscopy. Mucoid degeneration was almost invariable in mitral valve leaflets.These results suggest that spontaneous chordal rupture is more likely to be the result of abnormal mechanical strain rather than a diffuse connective tissue abnormality affecting multiple chordae. They may also provide theoretical justification for reconstruction rather than replacement of mitral valves in this conditio

ISSN:0022-3417    

DOI:10.1002/path.1711330303

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThirty‐eight nephrectomy specimens and two biopsies of perinephric abscesses from patients with xanthogranulomatous pyelonephritis have been examined. Twenty showed evidence of venous damage. This included organised thrombi in 12, intimal thickening in five and phlebitis in three. All specimens showed evidence of previous haemorrhage in the form of haemosiderin deposition. These findings differed significantly from a control series of chronic pyelonephritis.It is suggested that venous occlusion and haemorrhage are factors in the pathogenesis of the lipid accumulation in the kidney which is characteristic of this condition.The association of a papillary transitional cell carcinoma of the pelvis in a patient with xanthogranulomatous pyelonephritis is reported for the first tim

ISSN:0022-3417    

DOI:10.1002/path.1711330304

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractWhen a small dacron sponge disc containing live BCG was implanted subcutaneously in healthy subjects it became infiltrated with leukocytes which at 24 hours mainly involved neutrophils. This mycobacterial‐induced inflammatory response was markedly impaired in patients with cancer. This inhibitory effect could be reproduced by injecting the plasma of these patients into guinea‐pigs bearing identical discs. The differences in inflammatory reactions in the indirect technique were less marked than in the direct test, though a parallelism between the two was seen. The fact that the plasma from cancer patients interferes with neutrophil responses in this way does not exclude the possibility that abnormal cellular functions were also operative. Since tumour growth control depends on effective inflammation these data further underline the importance in cancer patients of a defect at this le

ISSN:0022-3417    

DOI:10.1002/path.1711330305

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe subcutaneous tissue of rats was injected with plasma, PVP or saline. Precautions were taken to avoid Immunological reactions and the release of mediators. The repeated injection of plasma proteins caused changes typical of chronic inflammation in the skin and to a much greater extent in the fascia. Coumarin significantly reduced the extent of this inflammatory reaction in the skin but not in the fascia. It increased the numbers of cells in the skin and may have stimulated them to lyse the excess protein. After 32 days, PVP injection caused some of the changes seen in chronic inflammation, but to a much lesser extent than those found with plasma. The only effect of coumarin was to reduce the water content of the skin (and hence the skin weight).It is concluded that the accumulation of excess proteins in the tissues can indeed cause chronic inflammation. In particular, chronic lymphoedema can be regarded as a form of chronic inflammation. It is also concluded that in the presence of excess protein, the benzopyrone, coumarin, is capable of stimulating cells, other than macrophages, in the skin.

ISSN:0022-3417    

DOI:10.1002/path.1711330306

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe subcutaneous tissue of rats was injected with plasma. PVP, or saline. In spite of precautions to avoid immunological reactions and the release of mediators, it was found that the plasma‐injected animals had many of the signs of chronic inflammation—even at 64 days. These were considerably reduced by coumarin, a benzo‐pyrone, which is known to enhance the lysis of proteins by macrophages. The numbers of these cells were greatly increased in the injection site—especially with the administration of coumarin. PVP also moderately increased macrophage numbers, but did not cause the increase in fibroblast numbers or collagen formation associated with the plasma‐injections. It is concluded that altered proteins in the tissues are a cause of chronic inflammation and that, in particular, chronic lymphoedema is a form of chronic inf

ISSN:0022-3417    

DOI:10.1002/path.1711330307

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711330301

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY