|
1. |
Functional and morphological changes in post‐capillary venules in relation to lymphocytic infiltration into BCG‐induced granulomata in rat skin |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 1-12
Anthony J. Freemont,
William L. Ford,
Preview
|
PDF (1300KB)
|
|
摘要:
AbstractVessels identical to iymph node high endothelial venules (HEV) have been described in sites of non‐lymphoid tissue lymphocyte accumulation. In this study the function of these (HEV‐like) vessels has been investigated in BCG‐induced skin lesions in the rat. By following the traffic of radiolabelled lymphocytes from the blood into the lesions the HEV‐like vessels have been shown to be the preferred site of migration. The complicated development of the vessels has been studied and an hypothesis advanced to explain their inter‐relationship with tissue and circulating ly
ISSN:0022-3417
DOI:10.1002/path.1711470102
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
2. |
Renal tubular epithelia ultrastructure in autolysis |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 13-21
I. E. El‐Shennawy,
D. J. Gee,
S. R. Aparicio,
Preview
|
PDF (1003KB)
|
|
摘要:
AbstractPost‐mortem changes in the proximal and distal tubules of rat kidneys leftin situhave been studied at the light microscope and ultrastructural levels. The distal tubular nuclei showed distinct changes which were completely different from the usual nuclear appearances after death and resemble the changes seen in apoptosis. These observations suggest that the unusual changes in the autolytic distal tubular nuclei may be due to the activation of endogenous endonuclease
ISSN:0022-3417
DOI:10.1002/path.1711470103
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
3. |
Radial scars of benign and malignant breasts: Comparative features and significance |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 23-32
T. J. Anderson,
S. Battersby,
Preview
|
PDF (992KB)
|
|
摘要:
AbstractFrom a study of tissue from 34 cancerous breasts and 34 benign breasts the nature and occurrence of radial scars has been assessed. The frequency of detection was influenced more by the amount of tissue assessed and by the diligence of search than by any association with cancer. Bilaterality and multifocality were features in cancerous and benign breasts and a similar range of scar histological appearance was apparent in both types. The histological features of 103 radial scars were tabulated to compare the association of characteristics within individual scars, and the information used to formulate modes of development and progression. The ‘early’ stage appeared to correlate with central chronic inflammatory response, many spindle cells and minor fibroelastotic distortion of parenchyma; the ‘late’ stage showed few spindle cells and dominant fibroclastosis with considerable distortion and separation of parenchymal elements. No support was found for the concept that the lesion is premalignant. Rather it belongs to the spectrum of sclerosing alterations affecting the breast parenchyma which ranges from physiological through to clearly pathological changes. Position in the spectrum depends upon the extent and degree of
ISSN:0022-3417
DOI:10.1002/path.1711470104
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
4. |
Myofibroblast activity of radial scars |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 33-40
S. Battersby,
T. J. Anderson,
Preview
|
PDF (943KB)
|
|
摘要:
AbstractRadial scars from 38 cases, comprising 12 associated with cancer and 26 with benign lesions, have been examined by electron microscopy. One‐third of the lesions, regarded as being at an early stage of development, showed abundant spindle cells, which displayed the ultrastructural characteristics of myofibroblasts. These included many profiles of endoplasmic reticulum, prominent myofilaments and a close association with collagen and elastic fibres. The remaining ‘mature’ radial scars showed relatively few myofibroblasts, sparsely distributed in the stroma. The stromal cells associated with the ‘early’ lesions were seen in close proximity to degenerating parenchymal struclures, which frequently showed loss of basal lamina. Obliteration of the central parenchymal component appeared to be a prominent feature of radial scar formation. The ultrastructural appearances are consistent with a progressive development of the lesion, associated with sporadic myofibroblast
ISSN:0022-3417
DOI:10.1002/path.1711470105
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
5. |
Effects of endotoxin‐treatment on inflammatory cell infiltrates in murine meth A sarcoma |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 41-48
C. Frieke Kuper,
Nanne Bloksma,
Joost P. Bruyntjes,
Frans M. Hofhuis,
Gerrit Wolterink,
Preview
|
PDF (719KB)
|
|
摘要:
AbstractThe effect of intravenously injected endotoxin on inflammatory cells within solid Meth A tumours was studied and central hyperaemia, necrosis and early collapse were observed macroscopically at 4, 24 and 48 h, respectively. The effects were studied in semithin sections and cytocentrifuge preparations of the tumours. The inflammatory cell reaction evoked by the tumours in untreated animals was relatively slight. It was located predominantly around the lateral margins of the tumours and only a few inflammatory cells were found inside the tumour. Prominent effects of endotoxin included a transient increase of mononuclear inflammatory cells in the centre of the tumour by 4 h and a reduction of the influx of lymphocytes, observed in and around the margin of control tumours, by 48 h. Mast cells formed an important part of the inflammatory cell infiltrate, but no distinct changes in number and appearance were observed with time or following treatment. Total host cell numbers within tumours did not increase significantly upon endotoxin‐treatment. Results suggest that a direct cytotoxic action of host cells cannot account for the extensive tumour damage observed. Rather, endotoxin‐induced regression seems to be related to decreased lymphocyte numb
ISSN:0022-3417
DOI:10.1002/path.1711470106
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
6. |
Synovial sarcoma: An immunohistochemical study |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 49-57
J. R. Salisbury,
P. G. Isaacson,
Preview
|
PDF (990KB)
|
|
摘要:
AbstractThe immunohistochemical staining pattern of 18 cases of synovial sarcoma with two epithelial‐specific monoclonal antibodies is described. This is compared with normal synovium, cases of giant cell tumour of tendon sheath (benign synovioma) and a variety of spindle celled sarcomas. Sixteen cases of synovial sarcoma showed staining of the epithelial component with at least one antibody. No staining was seen in normal synovium or in giant cell tumours of tendon sheath. A small number of malignant schwannomas contained groups of cells which stained positively whilst other spindle cell sarcomas either did not stain or showed ‘cross‐reaction’ type staining only. These results add weight to the proposition that synovial sarcomas do not arise from normal synovium, despite their morphological similarities, but from mesenchymal connective tissue. It is also shown that immunohistochemical staining with anti‐epithelial antibodies will emphasize the biphasic pattern of synovial sarcomas allowing their distinction from other
ISSN:0022-3417
DOI:10.1002/path.1711470107
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
7. |
Distribution of dense core granules in normal, benign and malignant breast tissue |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 59-65
D. J. P. Ferguson,
T. J. Anderson,
Preview
|
PDF (880KB)
|
|
摘要:
AbstractIn this study breast tissue from 114 patients has been examined ultrastructurally for dense core granules (DCG). The tissue included examples of normal ‘resting’, pregnant and lactating breast plus various benign and malignant lesions. DCG were observed in low numbers in the apical cytoplasm in a proportion of the examples of ‘resting’ and pregnant breast tissue but were absent in the lactating patients. The incidence appeared to relate to hormonal changes. They were present in 50 percent of the benign lesions examined. DCG were also observed in a high proportion of the ductal, lobular and tubular carcinomas examined and were associated with luminal differentiation. In the mucoid carcinomas over half the tumours possessed some DCG with large numbers of DCG present within certain of the malignant cells in two cases. It is possible that the granules could be related to mucin secretion. Therefore, in normal, benign and malignant (with the exception of mucoid carcinoma) breast tissue the presence of DCG would appear to be related to hormonal changes and represent prelactational differentiation rather than providing evidence of neuroendocrine differentiation. We emphasize the need for a comprehensive knowledge of the normal morphological variations within a tissue before attempting to interpret its
ISSN:0022-3417
DOI:10.1002/path.1711470108
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
8. |
Immunohistochemistry and histogenesis of extraskeletal myxoid chondrosarcoma |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 67-68
C. D. M. Fletcher,
P. H. McKee,
Preview
|
PDF (159KB)
|
|
ISSN:0022-3417
DOI:10.1002/path.1711470109
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
9. |
Orthopaedic diagnosis: Clinical, radiological and pathological co‐ordinates. H. A. Sissons, R. O. Murray and H. B. S. Kemp. Springer, Berlin, Heidelberg, New York, Tokyo, 1984. No. of pages: vii + 403 (including 534 figures). Price: £56.00 (approximately). ISBN: 0387 12795 X |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 69-70
P. D. Byers,
Preview
|
PDF (228KB)
|
|
ISSN:0022-3417
DOI:10.1002/path.1711470110
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
10. |
Pathology of skeletal muscle. S. Carpenter and G. Karpati. Churchill‐Livingstone, New York, Edinburgh, London, Melbourne, 1984. No. of pages: xiv + 754. ISBN: 0 443 05068 2 |
|
The Journal of Pathology,
Volume 147,
Issue 1,
1985,
Page 70-71
M. M. Esiri,
Preview
|
PDF (230KB)
|
|
ISSN:0022-3417
DOI:10.1002/path.1711470111
出版商:John Wiley&Sons, Ltd.
年代:1985
数据来源: WILEY
|
|