ISSN:0022-3417    

DOI:10.1002/path.1711330202

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711330203

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractA histological study of the lungs of guinea‐pigs that inhaled carbon, chrysotile asbestos or crocidolite asbestos dust indicated that dust particles in macrophages move through alveolar walls towards the pleura. After some weeks accumulations of dust‐filled macrophages were found near to pulmonary blood vessels. Macrophages that ingested carbon appeared to be much less mobile than those that ingested asbestos.In sections from the animals that inhaled asbestos, macrophages were found that were penetrating the wall of blood vessels, some carrying asbestos fibres. It is probable that some inhaled dust is transferred to extrapulmonary sites by macrophages in the bl

ISSN:0022-3417    

DOI:10.1002/path.1711330204

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe spinal cord and meninges were examined, at all levels, in seven anencephalic fetuses of between 19 and 24 weeks of gestation. Four of the seven anencephalics showed dense collections of cells resembling immature neural tissue throughout the spinal subarachnoid space. The leptomeninges were excessively vascular and contained many active macrophages and small round cells in all the anencephalics and the cord was more slender than normal. Control fetuses did not show these features, although inactive macrophages were seen occasionally.It is concluded that the abnormal collections are made up of heterotopic neural tissue which may have been dislodged downwards from the skull during earlier development and that the spinal leptomeninges show an inflammatory response. The significance of both the heterotopia and the phagocytic activity in these anencephalic fetuses is discussed. In particular, the findings are compared with those in patients with the “respirator brain” syndrome, in whom displacement of brain tissue is associated with raised intracranial press

ISSN:0022-3417    

DOI:10.1002/path.1711330205

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractMethods used to separate macrophages from human lympho‐medullary tissue samples have been applied to involved and uninvolved spleens and lymph nodes from 44 patients with Hodgkin's disease. The tumour samples yielded a population of ultrastructurally atypical cells with the anatomical and functional attributes of macrophages. The findings suggest that the macrophage was the neoplastic element in the cases of Hodgkin's disease studied.A feature of samples of uninvolved tissue from Hodgkin's disease patients was that there were fewer macrophages identifiable in the samples than in normal control tissues. These findings suggest that there may be a deficiency of normal macrophages as well as macrophage ncoplasia in this disease. Both abnormalities would contribute to the defective cell‐mediated immunity which is a characteristic of Hodgkin's dise

ISSN:0022-3417    

DOI:10.1002/path.1711330206

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe adherencein vitroof leucocytes to the surface of various stages in the life cycle ofT. spiralisandN. brasiliensisin the presence of serum was examined. Considerable differences were observed in the behaviour of mast cells, eosinophils, neutrophils and macrophages in this interaction. Mast cells adhered for a short time, did not flatten onto the surface and did not degranulate. Adherence ceased after 4–6 hr. Eosinophils adhered within minutes to the surface of worms, flattened and degranulated; only their cytoplasmic remnants could be seen on the worms' surface after 24 hr in culture. In contrast, only a small area of the cytoplasmic membrane of neutrophils flattened on the surface of the worms and adherence ceased after 2–24 hr. The NBT conversion reaction showed a positive deposit at the interface between neutrophils and parasites during neutrophil adherence. This deposit remained as “foot prints” on the surface of the nematodes following neutrophil detachment. This positive NBT reaction occurred only with neutrophils and not with eosinophils, mast cells or macrcphages. Macrophages adhered permanently to the surface of these worms, they did not flatten and retained their integrity. Under the light microscope the cytoplasmic inclusions appeared to decrease in size during culture. Electron microscopy revealed the presence of fewer granules and an increased number of vacuoles in later cultures of macrophages.These findings are discussed in relationship to the immuno‐pathology of nematode infecti

ISSN:0022-3417    

DOI:10.1002/path.1711330207

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711330201

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY