摘要:

AbstractTwelve human oesophageal carcinoma samples were examined by both light and electron microscopy in order to characterise the ultrastructural features of this neoplasm. Those samples from well differentiated tumours contained abundant tonofilaments, mainly in a paranuclear position, while cells from poorly differentiated tumours displayed few such filaments but had more prominent cytoplasmic organelles. Desmosomes were well developed in all samples, some of which displayed numerous clearly defined intracellular desmosomes not necessarily associated with cell membrane material. Myelinoid figures were abundant and the bizarre forms which were present in some samples may be related either to abnormal metabolism or to viral activity. Glycogen, lipid droplets and intermediate filaments, possibly related to basement membrane material were observed in several samples, No single feature diagnostic for carcinoma of the oesophagus emerged from this study, but several structural similarities between oesophageal and other carcinomas were noted.

ISSN:0022-3417    

DOI:10.1002/path.1711350202

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractFollowing a short period of fasting, with free access to water, lipid droplet accumulation (LDA) occurs in many glandular organs as well as in the heart of several species. The present work describes the changes in the hearts of male and female rats of different ages (6, 12, 18 and 24 weeks) deprived of food for 1, 2 and 3 days. LDA was demonstrated by staining with Oil Red O and a special “scoring” system was developed based on sections arbitrarily divided into five regions for each ventricle and two for each atrium. Three standard section were studied from each heart. This system largely avoided problems arising from the uneven distribution of fats in different parts of the heart.In control animals very little fat was seen in any part of the heart. The pattern of changes was similar in males and females but the degree of LDA was usually much greater in the male. In both sexes LDA increased after 1 day and usually reached a peak by the second day, followed by a sharp decrease, returning to almost normal. However in both sexes the response in the 18‐week‐old animals was minimal, with no clear peak.The LDA was always maximal in the R Ventricle, followed by the L ventricle. The heaviest deposition occurred in the superior parts of the ventricles, close to the atria. LDA was comparatively rare in the atria. Fat appeared to be longest in the most heavily loaded regions. Recovery from LDA was rapid, being almost complete 24 hr after returning to a normal diet. Again the most heavily loaded regions retained longest.These findings are discussed in relation ot possible anatomical factors such as the distribution of blood vessels. It It unlikely that such factors offer an adequate explanation and it is suggested that since the uptake of fats into the heart is probably controlled by lipoprotein lipase the distribution of this enzyme in different parts of the heart should be investigated. The histochemical changes are also discussed in relaion to previous biochemical work. Finally it is pointed out that it is common procedure to fast experimental animals overnight and even such a brief period could bring about considerable histological and metabolic

ISSN:0022-3417    

DOI:10.1002/path.1711350203

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractMicrofocal projection radiography was used to examine a new model of experimentally induced inflammatory arthritis, developed at Roche Products Ltd. The high resolution and magnification of the stereoprojection radiographs provided a non‐destructive and three‐dimensional assessment of the changes in the arthritic knee joints and enabled direct measurements to be made from the radiographs.During the time course study it was possible to quantify the increase in the size of the suprapatella bursa in the early stages of the inflammatory process, the onset and development of erosions in the articular bones and both juxta‐articular and systemic osteoporosis.The results of the quantitative radiographic study when compared with standard arthritis assay techniques of knee diameter and flexion showed maximum damage when the latter were near normal. Histology confirmed the radiographic results, although, alone it did not contribute substantially to the assessment of the changes occurring in the diseased joints.The measurements from the projection radiographs showed that the destruction of the articular bone progressed rapidly subsequent to subperiosteal erosions and consequent invasion of pannus into the epiphyses. The rate and degree to which articular bone was destroyed was independent of the extent to which juxta‐articular and systemic osteoporosis had developed.Microfocal projection radiography has considerable advantages over any other method in quantifying the changes in arthritic joints for evaluating the pathogenesis of the arthritis and in screening different co

ISSN:0022-3417    

DOI:10.1002/path.1711350204

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractNZR/Gd is a new inbred strain of albino rats subject to epithelial mesotheliomas of the heart and also to hepatic glycogen storage disease. The age‐specific incidences of neoplasms in 650 untreated NZR rats are tabulated by sex and histopathologic type. In males the most common neoplasms were atrio‐caval mesotheliomas (12 per cent.) and lung adenomas (10 per cent.), while in females most were pituitary adenomas (23 per cent.), lung adenomas (10 per cent.) or tumours of breast (7 per cent.), heart (4 per cent.) or liver or uterine cervix (3 per cent.). Uncommon tumours (less than 2 per cent.) were pancreas islet cell adenomas, lymphoma, hemangioma, fibroma or tumours of kidney, ovary or bile ducts. The detailed histopathology of the atrio‐caval tumours reported earlier was confirmed, but it now appears there is a male preponderance (4:1), and larger tumours showed their malignancy by invasion of adjacent structures and occasionally by distant metastasis. In males the primary site was evenly divided between right atrium and inferior vena cava. Metastasis of tumours of all types was uncommon, but multiple primary tumours were frequently found, especially in the endocrine system of female rats. Almost one‐third of the tumours were associated with at least one other neoplasm arising in a different tissue.Overall tumour statistics in NZR/Gd rats were quite similar to other inbred strains for which quantitative reports are available, and the virtual absence of other diseases and long life‐span (up to 1250 days) indicated no serious effect of the hepatic glycogen storage disease on survival. The NZR rats seem to be unique in producing atrio‐caval mesotheliomas. and they have a much higher incidence of alveolar lung adenomas (10 per cennt.) tham other repor

ISSN:0022-3417    

DOI:10.1002/path.1711350205

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractGout is principally a disease of middle‐aged men. There has been a lot of discussion over the cause of the renal lesion, whether it is age, hypertension or crystal induced, as single factors or in combination.We have recently been able to study renal biopsies from three related young women with an hereditary gout, and another girl with 2,8‐dihydroxyadenine crystal nephropathy. All were normotensive. These findings were compared with the findings of a crystal‐induced nephropathy in pigs. In the renal biopsies many stages of acute and chronic nephritis were found which were similar to the crystal nephropathy in the pigs. We concluded that the cause of the original lesion in the women was crystal deposition in the tubules, that crystals were not necessary to keep a non‐specific nephritis active and that age and hypertension need not be contributory

ISSN:0022-3417    

DOI:10.1002/path.1711350206

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711350201

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY