ISSN:0022-3417    

DOI:10.1002/path.1711440402

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711440403

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe metalophil method has been performed on 250 sections of a wide variety of inflammatory and neoplastic lesions in which different types of histiocytes might be encountered. In lymph nodes, dendritic histiocytes related to the B‐lymphocyte system were consistently metalophil. They appeared as small cells with slender extensions in lymph nodes with follicular hyperplasia and/or sinus histiocytosis and in some cases of Hodgkin's lymphomas or as larger pleomorphic cells in primary or secondary malignancies of lymph nodes. Small, rounded cells were seen in some cases of marked paracortical reaction, in dermatopathic lymphadenitis and in some cases of mycosis fungoides. These cells most probably represented Langerhans cells and interdigitating reticulum cells, which are related to the T‐lymphocyte system. Interdigitating cells become metalophil when they are activated or proliferating. Epithelioid cells in different benign and malignant lesions were metalophil like the sinus histiocytes of the lymph nodes, the Kupffer cells of the liver and the alveolar histiocytes in the lung. Foreign‐body giant cells in lymph nodes after lymphography were also metalophil. The sinus lining cells lymph nodes were also well‐delineated. Histiocytes of malignant histiocytic proliferations were sometimes metalophil as were the so‐called histiocytes in malignant fibrous histiocytomas. Epithelial cells, particularly the basal cells of squamous epithelium often take up the silver. Carcinoma cells were sometimes metalophil and the method appeared not to be of value in the differentiation between metastatic carcinomas and lymphomas. The most promising application seems to be the study of the distribution of dendritic histiocytes in malignant proliferations of B‐

ISSN:0022-3417    

DOI:10.1002/path.1711440404

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe metalophil method for the demonstration of histiocytes was applied to 108 non‐Hodgkin lymphomas diagnosed according to the Kiel classification. In 41 lymphomas the presence of histiocytes was assessed with the aid of the non‐specific esterase reaction. The same procedures were performed on 12 lymph nodes with follicular hyperplasia and/or sinus histiocytosis. The number of histiocytes was estimated and graded from 0 to 3. A good correlation between the two methods was found. Dendritic histiocytes were typically absent in lymphocytic lymphomas (CLL type). The follicles were clearly delineated by the distribution of dendritic histiocytes in follicular centroblastic/centrocytic lymphomas. In diffuse centrocytic lymphomas a small to moderate number of siender dendritic histiocytes was seen (grades 1–2). In lymphoplasmacytic/lymphoplasmacytoid lymphomas and in diffuse centroblastic/centrocytic malignant lymphoma the majority showed a great number of pleomorphic dendritic histiocytes (grade 3). In high‐grade malignant lymphomas (centroblastic, immunoblastic and lymphoblastic categories) either a high to moderate number of pleomorphic dendritic histiocytes was found or they were totally absent. The lack of histiocytes in centroblastic lymphomas was especially noteworthy. It is proposed that dendritic histiocytes proliferate or are attracted in malignant lymphomas by the presence of centrocytes, especially in combination with centroblasts and by the presence of plasmacytoid cells or their precursors. The frequent absence of dendritic histiocytes in high‐grade malignant lymphomas may alternatively be explained by the loss of physiological properties in less differentia

ISSN:0022-3417    

DOI:10.1002/path.1711440405

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA detailed histological study of the axillary nodes from 98 breast carcinoma patients, in which 5 and 10 year follow‐up data was available, has been undertaken. The presence of tumour cells in efferent vessels appears to be the only factor which is a marker of poor prognosis. Contrary to previous reports the direct infiltration of tumour cells through the nodal capsule into perinodal fat and connective tissue is of no prognostic significance. Distinction between site and type of tumour growth within nodes is thus essential for prognostic evaluatio

ISSN:0022-3417    

DOI:10.1002/path.1711440406

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractLymph node lesions attributable to ischaemia are described in the mesenteric nodes from 10 patients with volvulus of the small and large bowel. Frank infarction, the microanatomy of which differs from that seen in superficial lymph nodes, is one of the nodal lesions evoked by ischaemia. Two others in the form of lymphocyte depletion and capsular hypervascularity also appear to result from vascular occlusion. These three lesions were also found in nodes associated with ‘primary’ venous and arterial infarction of the bowel mucosa, but not in non‐vascular diseases of the small bowel or colon. The enhanced frequency of infarction in volvulus with mucosal necrosis, as opposed to cases with ‘primary’ vascular thromboses suggest that ischaemic lymph node changes are more frequent when several sets of vessels are occluded. Distension of lymph hode sinuses, erythrocyte extravasation, and dilatation of small intranodal vessels were not restricted to vascular cases, and appear to be less specific reactions to ischaemia. The range of ischaemia‐induced reactions is wider than has hitherto been recognized in human

ISSN:0022-3417    

DOI:10.1002/path.1711440407

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe presence of focal collections of lymphocytes within the thyroid gland has been associated with autoimmune thyroiditis. In a prospective study 197 thyroid glands were examined from post mortems performed in two Southampton hospitals over a 12 month period. The mean thyroid mass was 19·5 g in women and 22·2 g in men. Varying degrees of focal lymphocytic thyroiditis were present in 54 per cent of women and 24 per cent of men. Morphometry showed that on average less than 4 per cent of the gland was infiltrated by lymphocytes. There was no significant relationship with age. A possible association between focal lymphocytic thryoiditis and circulating thyroid autoantibodies has been show

ISSN:0022-3417    

DOI:10.1002/path.1711440408

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractAn 18‐month‐old infant with recurrent congenital hydrocele presented with a mass in the caput epididymis. The tumour and several fragments of the tunica vaginalis were removed and studied by light and electron microscopy. The tumour showed the characteristic histological pattern of an adenomatoid tumour of mesothelial origin. The histological appearance of the tunica vaginalis was not uniform; some areas resembled the adenomatoid tumour to the epididymis, others exhibited histological and ultrastructural features of a haemangioma, whilst elsewhere, the two patterns were intermingled. Finally, areas of pseudofibromatous periorchitis with vascular proliferation and slit‐like structures lined by mesothelial cells were recognized. These features suggest that the adenomatoid tumour originated from a localized reactive process with inflammation and vascular proliferation enclosing occasional slit‐like structures originating from the mesothelial lining of the tunica vaginalis. Subsequent regression of vascular proliferation and inflammatory infiltration and continued mesothelial proliferation would give rise to the typical mesothelial pattern of adenomatoid

ISSN:0022-3417    

DOI:10.1002/path.1711440409

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractAmong the differentiated progeny of stem cells transplantable by bone marrow are osteoclasts, the multinucleate cells which are the major agents of bone resorption. Although the osteoclast is well characterized from a structural and functional standpoint, its development and origin are still far from clear. We have used monoclonal antibodies to investigate the interrelationship between osteoclasts and other haemopoietic cells in man. We have analysed the distribution of 19 granulocyte–monocyte antigens in eight reactivity clusters on the non‐neoplastic osteoclasts present within nine osteoclastomas (syn. giant cell tumours of bone) and a single example of aneurysmal bone cyst. We found that osteoclasts are antigenically effete, failing to express granulocyte‐monocyte, common leucocyte or other haemopoietic determinants; the only monocyte antigens detected on osteoclasts are My‐7 and two closely related specificities, MCS.2 and DüHL60.4, which are also expressed by tissues outside the haemopoietic system. Our findings, taken together with recent transplantation studies, cast further doubt on the view that osteoclasts are specialized bone‐resorbing macrophage‐derived giant cells, and support a hypothesis that they are the end product of fusion of a hitherto unidentified circulating mononuclear cell type, the preosteoclast, which constitutes a cell lineage separate from those originating from the conventional multipotential haemopoietic stem cell, although still of bone m

ISSN:0022-3417    

DOI:10.1002/path.1711440410

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711440411

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY