摘要:

AbstractThe implication of post‐mortem changes such as cell swelling, imbibition and autolysis on the elemental composition of body organs has been studied in rats. Liver has been chosen as an example. Retaining the liver inside the intact dead body for different periods of time at ambient temperature induced significant changes in its weight due to post‐mortem tissue degeneration. Livers from animals that were frozen at −15°C also showed significant decrease in weight when they were thawed on the third day. The effect of these changes on the concentrations of various elements depended on the association of the elements with extracellular fluid and intracellular components. For example, concentration of K+was affected more by the lysis of the cell and sustained losses up to 30 per cent, in relation to the control values, while the total content was reduced by more than 40 per cent. as a result of both lysis and tissue liquefaction. For Na+, differences ranging from +10 to −20 per cent. in concentrations and +20 to −40 per cent. in total content were observed which could be explained by the movement of fluid in and out of the organ. Among trace elements, variations observed for iron ranged from −20 to +40 per cent., while both copper and zinc were found to fluctuate between −20 and +20 per cent. The loss observed in the total content in the liver for the five trace elements studied (Cu, Fe, Mn, Rb and Zn) was found to be about 20

ISSN:0022-3417    

DOI:10.1002/path.1711340302

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractMale house mice (Mus musculus) were injected with 4 international units of ACTH daily for 1, 2, 3 and 4 weeks and with four units daily for four weeks followed by 8 units for 8 days. Light microscopy of kidneys showed a glomerular lesion characterised by the expansion of the mesangium, deposition of PAS positive material in the glomerular mesangium and extra‐glomerular mesangium hypertrophy of juxtaglomerular cells and a successive increase in oil red‐O staining material in the glomerulus. Electron microscopy revealed the progressive accumulation in the mesangial matrix of three morphologically distinct forms of deposits: amorphous, globular and particulate. The accumulation of amorphous deposit apparently is partially responsible for me increased PAS positive staining of the mesangium. Globular (and possibly particulate) deposit probably corresponds to the oil red‐O positive material. The evidence suggests that the deposits are extraglomerular in origin, but their chemical nature is un

ISSN:0022-3417    

DOI:10.1002/path.1711340303

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractIn three models of cholelithiasis (dihydrocholesterol‐fed rabbits, cholesterol‐cholic acid‐fed mice, and Lincomycin‐treated guinea pigs), the quantity and chemical composition of gallbladder epithelial mucin have been studied using (1) a spectrum of histochemical glycoprotein stains, and (2) biochemical extraction, purification and analysis of the carbohydrate components of epithelial mucin. Despite the diverse mechanism of stone induction and difference in stone composition, a common pattern of response by the epithelial mucin was observed in all three models. There was a quantitative increase in epithelial mucus production at a time before stones were formed and this increase persisted till stones were formed. There was no difference, qualitatively, between mucus produced by normal and stone‐forming gal

ISSN:0022-3417    

DOI:10.1002/path.1711340304

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractBy means of electron microscopy, three types of mesangial cell change were identified in IgA nephropathy. They represented proliferative, phagocytic and resting mesangial cells. The proliferative mesangial cells were characterised by the presence of centrioles, numerous free ribosomes, well developed Golgi apparatus and SER. They were found in the proliferative forms of IgA nephropathy. Phagocytic mesangial cells had numerous spinous cytoplasmic processes, better differentiated RER and numerous dense bodies and lipid inclusions. They were found in all histological forms of IgA nephropathy. The resting mesangial cells were unusual and were occasionally present in cases with normal numbers of mesangial cells.

ISSN:0022-3417    

DOI:10.1002/path.1711340305

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractFive‐day‐old female chicks were fed diets containing testosterone, estradiol, and cholesterol for 2 months. Cholesterol supplementation of 1 per cent. resulted in production of lipid vacuoles in the interlamellar connective tissue cells and to a lesser extent in the smooth muscle cells in the aorta; cholesterol had no effect on the coronary artery. The vasculo‐toxic nature of estrogen was indicated when 0·05 per cent, dietary estradiol produced more accumulations of lipid vacuoles in smooth muscle cells, more extracellular lipid, and more smooth muscle cell death than cholesterol feeding. A dietary combination of cholesterol plus estradiol produced severe lipid deposition throughout the entire thickness of ascending aorta, and degenerative atherosclerotic changes in the coronary artery. Combined testosterone and estradiol supplementation resulted in peculiar dwarf chickens which exhibited increased vascular smooth muscle cell mitosis and degene

ISSN:0022-3417    

DOI:10.1002/path.1711340306

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

Abstract41‐year‐old woman was admitted because of uterine bleeding. The diagnosis of malignant histiocytic tumor was suspected from microscopic examination of the material obtained with diagnostic curettage. Total hysterectomy was performed a week later and a complete pathological examination of the specimens was performed.Cytochemical and immunoperoxidase stains and electron microscopy confirmed that the neoplastic cells were derived from histiocytic elements, i.e. from the mononuclear phagocyte sys

ISSN:0022-3417    

DOI:10.1002/path.1711340307

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractHog kidney diamine oxidase (DAO) interacted with 1,3‐diaminopropane, putrescine and cadaverine to arrest proliferation of cultured mammalian cells. The byproducts of DAO‐substrate interaction, H2O2and NH 4+are themselves cytotoxic but were apparently not responsible for any significant antiproliferative effect in the experimental system. DAO is known to react with putrescine to generate labile 4‐aminobutyraldehyde. This primary product was compatible with a compound (radio‐labelled) separated from DAO‐putrescine reactive mixtures by ion‐exchange chromatography. Its rate of generation, level attained and lability (half‐life, 2 hr) in culture simulated conditions were measured. Circumstantial evidence suggested that the amine aldehyde products of diamine oxidation had a potent antiproliferative

ISSN:0022-3417    

DOI:10.1002/path.1711340308

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711340301

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY