摘要:

AbstractThe thoraco‐lumbar spinal cord of 4 cats were subjected to 4000 RADS of X‐irradiation. Between 3 and 5 mth afterwards the animals developed weakness of the hind‐legs and became incoordinated. Small infarcts were found in the white matter of the irradiated area of spinal cord, accompanied by neuronal death and oedema of the grey matter close to the central canal. Ultrastructurally the infarcts were shown to stem from necrosis and thrombosis of small blood vessels. Comparison is made with the pathogenesis of spinal cord infarction that occurs in decompression sic

ISSN:0022-3417    

DOI:10.1002/path.1711370402

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA conventional histopathological and quantitative morphometric study of 28 capsulated peripheral and spinal nerve benign schwannomas demonstrated linear and parabolic correlation between Antoni B tissue, vascularity and tumour size. The results support the endoneural connective tissue origin of Antoni B, and suggest a model of tumour growth that is partially limited by the growth potential of the Antoni B and/or the vascular component.

ISSN:0022-3417    

DOI:10.1002/path.1711370403

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe carotid bodies from 150 consecutive cases coming to necropsy were examined to determine the degree of anatomical variation of the organ. Single, double and bilobed variants were found. The origin of the carotid body was variable, the angle of the carotid bifurcation being the most typical, but a minority were encountered on the internal or external carotid arteries, the common carotid artery and the ascending pharyngeal artery. Carotid bodies which were enlarged had no preferred site of origin, but some showed early or pronounced nodularity.Both carotid bodies from 100 of these cases were subjected to detailed qualitative and quantitative histological study. From these measurements we were able to define hyperplasia of the organ as a differential sustentacular cell count in excess of 47 percent., a lobular diameter over 565 μ, and a combined carotid body weight over 30 mg. Carotid body hyperplasia occurred in cases of myocardial hypertrophy secondary to both hypoxaemia and systemic hypertension

ISSN:0022-3417    

DOI:10.1002/path.1711370404

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe severity of the renal papillary necrosis produced in rats by ethylenimine is dependent both on dose and urinary concentration within the medulla. When this is reduced by diuresis, the severity of the lesion is effectively reduced. Increasing urinary concentration has a reverse effect, but of less magnitude. When the concentrating power of the renal medulla is impaired by a single dose of ethylenimine, insufficient to cause necrosis of the whole papilla, further doses of ethylenimine do not cause progressive damage to the papilla.

ISSN:0022-3417    

DOI:10.1002/path.1711370405

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe area cerebrovasculosa has been examined in 35 anencephalic fetuses and coronal sections prepared in 15 cases. A bilaterally symmetrical cystic mass is found covering the anterior and middle cranial fossae. The mass is generally walled with glial tissue, partially lined with ependyma and filled with abnormally vascular choroid plexus. The coverings of the cyst are conspicuously vascular and the overlying squamous epithelium is in continuity with hairy skin at the margins of the lesion. The posterior cranial fossa contains a variable quantity of medulla oblongata which has no connection with the cystic mass. The medulla and cervical cord are more nearly normal in that minority of cases with an intact foramen magnum. The degree of hindbrain development is correlated with the previously reported presence of heterotopic glial tissue in the spinal subarachnoid space of some anencephalic fetuses (Bell, Gordon and Maloney, 1981; Bell, 1981, in press).These findings have led us to reject the widely accepted view that the area cerebrovasculosa is totally disorganised, and that anencephaly is characterised by absence of the forebrain.

ISSN:0022-3417    

DOI:10.1002/path.1711370406

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractComputerised scanning cytophotometry was used to evaluate the phagocytic and pinocytic performance of single resident and exudate macrophages. The results indicate that both receptor mediated phagocytosis and fluid phase pinocytosis are more efficiently performed by activated than resident murine peritoneal macrophages. Exudate macrophages phagocytise at approximately twice the rate of resident macrophages while pinocytosis is five times more prominent in exudate than in resident macrophages. The results are consistent with other published investigations and in addition reflect individual cellular variation in macrophage populations.

ISSN:0022-3417    

DOI:10.1002/path.1711370407

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

Abstract(1) The effects of hydrocortisone succinate (1.0.–0.01 μ HC/ml of medium) on porcine articular tissues in organ culture have been studied by histological and biochemical methods.(2) 1.0 and 0.1 μg HC/ml considerably inhibited the severe breakdown of matrix that occurs in living and dead cartilage explanted in contact with synovial tissue.(3) The depletion of matrix in living cartilage cultivated in the same dish as but not in contact with synovial tissue, is much diminished when the medium contains 1.0 or 0.1 μg HC/ml.(4) Cartilage grown in the used medium of synovial tissue loses both proteoglycan and hydroxyproline; the addition of HC to the used medium has little (1.0 μg HC/ml) or (0.1 μg HC/ml) no inhibitory effect. If, however, the used medium is from synovial tissue that has been cultured in the presence of 1.0 or 0.1 μg HC/ml, loss of proteoglycan and collagen from the cartilage is much reduced.(5) In isolated cartilage in normal medium there is outgrowth of cells from the cut surface and some loss of proteoglycan and collagen; outgrowth is completely, and loss of matrix components partially suppressed by 1.0 μg HC/ml.(6) Isolated synovial tissue cultured in normal medium shrinks to about one‐third of its original size, loses much of its collagen and secretes neutral metallo‐proteinases into the medium; in the presence of 1.0 μg HC/ml these changes are largely prevented. The explants also secrete an inhibitor of metallo‐proteinases the production of which is no

ISSN:0022-3417    

DOI:10.1002/path.1711370408

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711370401

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY