ISSN:0022-3417    

DOI:10.1002/path.1711600202

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

摘要:

AbstractIn this paper we report two cases in which morphological differentiation of gastric adenocarcinoma has occurred when metastatic tumour was present within the lamina propria of the intestinal mucosa. In one case, there were metastases in the small intestinal mucosa and in the second case, in the mucosa of the appendix. The morphology of the intramucosal tumour simulated that of an adenomatous neoplasm. The recognition of this occurrence may be important in the differential diagnosis of primary and secondary adenocarcinomas of the gastrointestinal tract. The phenomenon is not only of diagnostic interest: the data presented here providein vivoevidence that gastrointestinal carcinomas may differentiate in response to epithelial–mesenchymal interactions in a similar way to that seen in experimental model

ISSN:0022-3417    

DOI:10.1002/path.1711600203

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

摘要:

AbstractThe lungs from 16 cases of plexogenic pulmonary arteriopathy obtained at heart‐lung transplantation, half of which had primary pulmonary hypertension, were examined by electron microscopy. From these the probable pathogenesis of pulmonary arterial intimal fibrosis in plexogenic pulmonary arteriopathy was deduced. The earliest detectable change was migration of smooth muscle cells from the media; through the internal elastic lamina into the intima. These cells collected beneath the endothelium and lost many of their myofilaments to become myofibroblasts. They were associated with ground substance but scanty collagen fibrils. As the quantity of interstitial collagen increased, the myofibroblasts reverted to a muscular structure, became elongated, and assumed a regular, circumferential orientation. This later stage coincided with the development of plexiform lesions. At both early and later stages, the muscular pulmonary arteries were contracted but not markedly so, and muscular evaginations were not seen. On the other hand, the cellular intimal proliferations developed early and were occlusive. This suggests that occlusion of small pulmonary arterial vessels by myofibroblasts may be at least as important as vasoconstriction in the early elevation of the pulmonary vascular resistance in primary pulmonary hypertensio

ISSN:0022-3417    

DOI:10.1002/path.1711600204

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

摘要:

AbstractA prospective study of 78 pregnant women was undertaken to detect maternal enterovirus infection. Maternal faecal specimens and blood samples, placental and fetal tissue were taken for viral study, electron microscopy, histochemistry, and morphological examination.We present the post‐mortem findings in three fetuses whose maternal infection was detected before delivery by isolation of ECHO virus type 33 and type 27 from faecal specimens and or placental and fetal tissues. The morphological aspects were similar in all cases and included an acute infection of the placenta and hypoxic/hypotensive injury to fetal organs. In one case, viral particles were detected by electron microscopy of the fetal liver.This series of cases of intrauterine ECHO virus infection confirms the potential gravity of such infection during pregnancy and the need to prevent enterovtral diseas

ISSN:0022-3417    

DOI:10.1002/path.1711600205

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

摘要:

AbstractFor the detection of proliferating lipocytes in regenerating liver, partially hepatectomized rats were injected intrapcritoneally with 5‐bromo‐2′‐deoxyuridine (BrdUrd, 50 mg/kg body weight) and killed 1 h later. Acetone‐fixed frozen liver sections were used for the simultaneous detection of cytoplasmic desmin and BrdUrd‐labelled nuclei of lipocytes using double immunohistochemical procedures. The best results were obtained with the sequences: rabbit anti‐desmin → biotinylated anti‐rabbit IgG → avidin‐biotin‐peroxidase complex → 3,3′‐diaminobenzidine tetrahydrochloride, followed by DNA denaturation → mouse anti‐BrdUrd → anti‐mouse IgG → peroxidase‐anti‐peroxidase complex → 4‐chloro‐l‐naphihol. With this method, cytoplasmic desmin was stained a brown colour, which sharply contrasted with the blue‐stained BrdUrd‐labelled nuclei. Uniabelled nuclei appeared green after counterstaining with methyl green. No cross‐reaction between immunoreagents of desmin and BrdUrd stainings was observed. The labelling index of lipocytes peaked (25.7 percent) 48 h after partial hep

ISSN:0022-3417    

DOI:10.1002/path.1711600206

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

摘要:

AbstractIn murine sarcomas induced by 20‐methylcholanthrene, histological features of malignant fibrous histiocytoma (MFH) as well as rhabdomyosarcoma were found in the same tumour both at light microscopy and at ultrastructural level. The areas showing rhabdomyomatous differentiation expressed vimentin, desmin, muscle‐specific alpha‐actinin, and sometimes myoglobin, but in the MFH areas only vimentin was expressed. A series of allografts in athymic mice, using tumour areas of both histological types, showed in every case a mixed pattern of tumour growth, whether the transplanted tissue was of MFH or rhabdomyosarcomatous type. This suggests that the MFH areas in the original experimental sarcomas were modulated disguised rhabdomyosarcomas. The significance of MFH‐like areas in non‐related soft tissue sarcomas is also

ISSN:0022-3417    

DOI:10.1002/path.1711600207

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711600208

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

摘要:

AbstractImages from a generic videodisc called the 'Slice of Life' were utilized to develop computer assisted interactive videodisc instruction (IVI) units for supplemental independent review of the laboratory cases studied in the general pathology course for year 1 medical students. Four units based on laboratory cases (two on ‘inflammation’ and two on ‘neoplasia’) were developed for a dual‐screen Macintosh system. With this dual‐screen system, specific picture frames from the videodisc could be retrieved on one screen while the other screen displayed the corresponding text. Each unit contained a number of case studies, each of which consisted of a clinical profile, gross picture and description of the tissue removed, sequential photomicrographs at successively higher magnifications from various fields of slides and their descriptions, comparison with the normal histology of the organ involved, interpretation of the observations and comments, final diagnosis, and a quiz at the end. Histopathological features were specifically emphasized. Evaluation of the units obtained from three consecutive classes of students indicated that these units were received as valuable supplemental tools for independent review of the labor

ISSN:0022-3417    

DOI:10.1002/path.1711600209

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711600210

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711600212

出版商:John Wiley&Sons, Ltd.    

年代:1990

数据来源: WILEY