摘要:

AbstractA systematic ultrastructural study has been performed of the mononuclear phagocytes in granulomas induced by different types of mycobacteria, e.g. live BCG (Pasteur), irradiatedM. lepraeand irradiated BCG (Pasteur) in guinea pig lymph nodes. Live BCG (Pasteur) induces a granuloma which peaks at 2‐3 weeks and by light microscopy, a large number of the infiltrating cells have the appearance of epithelioid cells. Ultrastructurally a large proportion of these cells have a distinct appearance. They are characterised by the presence of very large nuclei, and prominent nucleoli, paucity of cytoplasmic organelles and swollen rough endoplasmic reticulum. Cells from 2 week granulomas induced by liveM. kansasiiand BCG (Glaxo), had a similar ultrastructural appearance. BCG (Pasteur) granulomas slowly resolved and by light and electron microscopy fibrosis and collagen deposition was seen by 7 weeks and was very extensive in some nodes at 10 weeks.The nodes from M. leprae injected animals showed peak infiltration at 5 weeks and by light microscopy the infiltrating cell population was more mixed, with most of the cells having a macrophage appearance. Electron‐microscopy showed these infiltrating cells to be mainly activated macrophages, containing phagocytosed organisms. Nodes from irradiated BCG (Pasteur) injected animals had peak infiltration at 1 week. The light and electron microscopic appearance showed areas consisting mainly of fibroblasts and mononuclear phagocytes. Thus, the granulomas induced byM. lepraeare very different from those induced by BCG in the guinea pig. It is suggested that lymph nodes draining areas of local injection of BCG and irradiatedM. lepraecould respectively form a good model in the guinea pig for cellular and biochemical studies of the granulomas of tuberculoid and lepromatous lepr

ISSN:0022-3417    

DOI:10.1002/path.1711340402

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractA herd of cattle which produces calves with generalised glycogenosis type II has been established. Seven affected animals have been born and their disease status as indicated by a decreased acid α‐glucosidase activity and excessive glycogen deposition in muscle, can be detected on the day of birth. Two animals have died of heart failure aged 3 and 5 months and have shown cardiomegally. Five animals were clinically normal until 9 months of age when they failed to maintain weight gain, showed muscle weakness and four were killed aged between 12 and 16 months after showing difficulty in rising. All affected animals had abnormal ECG tracings and had elevated levels of CK. LDH and HBDH in serum. Excessive amounts of glycogen were deposited in voluntary, cardiac and smooth muscle, and in cells of the nervous system. The muscles showed a vacuolar myopathy. Both the infantile and late onset forms of generalised glycogenosis type II are present in this herd of cattle. The condition appears to be controlled by a recessive allele at a single autosomal loc

ISSN:0022-3417    

DOI:10.1002/path.1711340403

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractCells from 11 malignant effusions have been examined for macrophage functional attributes and for evidence of macrophage malignancy.Three patients with Hodgkin's disease and one patient with histiocytic medullary reticulosis had atypical macrophages in their serous fluids. This adds further evidence to support the theory that the macrophage is the malignant cell in these tumour types.Two other patients with LRMPS tumours had atypical non‐adherent cells in their effusions; these were probably lymphoid in origin. Samples from patients with benign disease and with epithelial tumours did not have atypical LRMPS cells.One patient with Hodgkin's disease lacked the atypical macrophage. In this patient the ascites was not due primarily to tumour involvement. There was no evidence to suggest a Hodgkin's disease‐related macrophage deficit as has been reported in tissue samples.It is concluded that cells from malignant effusions are a particularly valuable source of information about the histogenesis of tumours which may be of macrophage ori

ISSN:0022-3417    

DOI:10.1002/path.1711340404

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711340405

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711340406

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711340401

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY