摘要:

An antiestrogen is a compound that blocks the action of estrogen. Most synthetic antiestrogens have agonistic or antagonistic activity depending on the tissue and the endogenous estrogen mileu. The triphenylethylene derivatives, clomiphene and tamoxifen, are the antiestrogens in greatest clinical use. Their biologic effects, clinical indications, and risks are reviewed. Novel antiestrogens which are beginning to be studied clinically include the benzothiophene derivative, raloxifene and the "pure" antiestrogens such as ICI 182,780. New clinical indications for existing compounds as well as the development of novel antiestrogens may lead to better treatment options for endocrine-dependent conditions.

ISSN:0029-7828    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Racial differences in rates of amniotic infection were examined through a review of the literature. Following a computerized and manual search of the literature from 1966 to 1994, studies were selected that reported the prevalence by race of presumed markers of amniotic infection. These markers included: amniotic infection syndrome, histologic chorioamnionitis, clinical chorioamnionitis, premature rupture of the membranes, and early neonatal mortality from sepsis. With the exception of overall rates of histologic chorioamnionitis, black women showed higher rates of the all the conditions examined. Insofar as amniotic infection is a risk factor for poor perinatal outcomes, the finding of higher rates of markers of amniotic infection among black women suggests that such infections may contribute to racial disparities in perinatal outcome.

ISSN:0029-7828    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Genital fistulas that complicate diverticular disease of the sigmoid colon may no longer be considered esoteric, or even rare phenomena. The vast majority of such lesions present with a foul, often fecal, sometimes purulent and occasionally blood-tinged, vaginal discharge for which patients customarily first seek relief from their gynecologists. Despite this fact, the topic is not mentioned in a single American textbook of gynecology. It is the purpose of this report to review the pertinent literature and to include the authors' experience with 13 additional cases in order to bring this topic to the attention of our gynecologic colleagues.

ISSN:0029-7828    

出版商:OVID    

年代:1996

数据来源: OVID