摘要:

13 patients with chronic inflammatory bowel disease were treated with an elemental diet (Vivasorb). Intestinal protein exudation was studied during the treatment by means of 131I-albumin. 131I-albumin studies showed no significant change of albumin degradation and, by inference, of intestinal protein loss in the group as a whole. A high initial albumin degradation rate augured treatment with elemental diet and prednisone to be unsuccessful. It is concluded that measurement of intestinal protein leakage is of no predictive value as regards the effect of treatment of chronic inflammatory bowel disease with elemental diet. Apparently, diminishing protein exudation is a late phenomenon during a course of clinical remission.

ISSN:0012-2823    

DOI:10.1159/000198058

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Zinc nutriture has been studied in 30 patients with Crohn’s disease using plasma zinc, hair zinc, and taste acuity as indices. Significant reductions in plasma zinc concentrations and taste acuity were seen in the patient groups as compared with normal controls. Hair zinc content was also generally low with several deficient values encountered among the Crohn’s patients. A highly significant correlation between plasma zinc and albumin suggests a possible role of plasma-binding alterations in the depressed plasma zinc levels of patients with Crohn’s disease patients and a potential influence on growth and healing in this disease must be consi

ISSN:0012-2823    

DOI:10.1159/000198059

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The inhibition of chymotrypsin activity by pig, dog, human and rat blood plasma was studied. N-Benzoyl-L-tyrosyl-p-amino-benzoate (PABA-peptide) was used as the substrate. Crystalline bovine chymotrypsin as well as activated lyophilized human, pig, rat and chicken pancreatic secretions were used as enzyme sources. Certain species differences were noted. Swine plasma had no effect on bovine or human chymotrypsin while it inhibited that of the chicken by 67%. Dog plasma was a potent inhibitor of chymotrypsin activity from all sources tested. An acute pancreatitis model using the rat was also developed in which pancreatic juice flow was blocked without interference with biliary flow. After 24 h, these animals had increased plasma amylase activity, decreased plasma protease inhibitor and decreased hematocrit. By 72 h, amylase, trypsin inhibitor and hematocrit had nearly recovered while chymotrypsin inhibitor had actually increased above control levels. In rats subjected to hepatectomy or to hepatectomy plus pancreatic blockage, plasma protease inhibitor was even more severely depressed and remained so.

ISSN:0012-2823    

DOI:10.1159/000198060

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Succus entericus from jejunal Thiry-Vella fistulae in fasting conscious dogs was analyzed for amino acids before and after incubation for 15 and 30 min at 38 °C in vitro. Total amino acid concentration of succus entericus as collected was about twice that of blood plasma. After incubation, it was increased 76% above control at 15 min and 137% at 30 min. Because succus entericus does not exhibit proteinase activity, and no enzyme or substrate was added before incubation, the increase in amino acid concentration was probably due to hydrolysis of peptides by peptidases normally present in the juice. Volume of secretion and output of amino acids were greatly increased by intravenous administration of glucagon, but the amino acid pattern was quite different from blood plasma. The concentrations of aspartic and glutamic acids were 10- and 5-fold greater than in plasma, and tryptophan was usually undetectable

ISSN:0012-2823    

DOI:10.1159/000198061

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The serum α-fetoprotein level was measured by radioimmunoassay in 200 patients when admitted to hospital, 63 with idiopathic hemochromatosis and 137 with liver cirrhosis. In addition, repeated controls were performed in 19 subjects of each group for a mean period of 11 months (range 3–18 months). Elevated α-fetoprotein levels were observed initially or during the study period in 15 patients, a malignant liver tumor being demonstrated in 12 of them. In 4 of these patients, the abnormal α-fetoprotein concentration was the clue to the diagnosis of an unsuspected malignant hepatoma, but in none of these cases could the tumor be resected. The present results indicate that screening the serum α-fetoprotein level may contribute to the detection of malignant hepatoma in high-risk clinical groups, but the practical interest of such screenings may keep limited until more efficient therapeutic methods are deve

ISSN:0012-2823    

DOI:10.1159/000198062

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Samples of serum were collected at 6- to 12-month intervals in two groups of healthy Africans and the amount of AFP measured by the radioimmunological method. The amounts present were found to remain fairly constant over time. The significance of this stability is discussed with particular reference of the highest levels of AFP observed in normal individuals in relation to primary liver carcinoma and the potential use of the method as a tool for early detection purposes.

ISSN:0012-2823    

DOI:10.1159/000198063

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A retrospective study was carried out to examine the influence of portacaval shunt (PCS) on serum bile acid concentration in 47 cirrhotic patients. Cirrhotic patients with PCS had a significantly higher serum bile acid concentration than cirrhotic patients without PCS whatever the duration between the diagnosis and the time of measurement. Serum bile acid concentration was significantly higher 3–12 months after PCS (67.90 ± SD 15.90 μM; p < 0.001) and 12 months or more after PCS (94.11 ± SD 33.86 μM; p < 0.001) than before the shunt (18.98 ± SD 13.62 μM). The mean concentration 12 months or more after PCS was significantly higher than that found 3–12 months after shunt (p < 0.02). This progressive increase in serum bile acid concentration may indicate a deterioration of hepatic function in shunted

ISSN:0012-2823    

DOI:10.1159/000198064

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A glycerol-ester hydrolase has been characterized and partially purified (23-fold) from human small intestine. A pancreatic origin was excluded through the use of an immunoserum directed against human pancreatic juice, while a pharyngeal (gastric) origin was unlikely owing to the optimum pH range of activity of the gastric enzyme as compared to that of the intestinal enzyme. The glycerol-ester hydrolase is mainly active toward short-and medium-chain di- and triglycerides and toward micellar long-chain monoglycerides. A role in the absorption of neutral lipids, mainly in pathological situations, is postulated.

ISSN:0012-2823    

DOI:10.1159/000198065

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The amylase to creatinine clearance ratio was found to be normal in 11 of 33 patients with acute pancreatitis. The ratio was elevated in 10 of 19 patients with renal insufficiency. Thus, it does not seem to be a specific index in the diagnosis of acute pancreatitis.

ISSN:0012-2823    

DOI:10.1159/000198066

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

External fistulation of the bile duct in rats caused a decrease in cell renewal, whereas bile duct ligation resulted in smaller villi and no change in cell renewal as compared to two control groups.

ISSN:0012-2823    

DOI:10.1159/000198067

出版商:S. Karger AG    

年代:1977

数据来源: Karger