摘要:

Rats were fed with a copper-deficient diet combined with penicillamine to produce an atrophy of the exocrine pancreas by selective destruction of the acinar cells, which are replaced by fat cells. Plasma cholecystokinin (CCK) concentrations in animals with exocrine pancreatic atrophy were 250% higher compared to control animals (21.7 ± 7.8 vs. 6.1 ± 1.07 pmol/l; p < 0.001). Plasma concentrations of gastrin were significantly decreased by 44 % and of gastric inhibitory polypeptide (GIP) significantly increased by 24 %, while the decrease of the plasma insulin did not reach the level of significance. In the proximal duodenum a significant decrease of the CCK concentration could be observed, whereas tissue concentrations of GIP in duodenum and jejunum and gastrin in the gastric antrum remained unaltered. These data suggest that the negative feedback control of pancreatic enzyme secretion is mediated by the release of CC

ISSN:0012-2823    

DOI:10.1159/000199010

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000199011

出版商:S. Karger AG    

年代:1984

数据来源: Karger