摘要:

A manometric study of the distal biliary tract was carried out by means of a side-hole perfused catheter passed through the papilla Vateri during duodenoscopy in patients with postcholecystectomy biliary pain not due to stones or inflammation of the biliary tree. The sphincter of Oddi showed in these cases a significantly higher basal tone than in controls with superimposed phasic pressure waves of high amplitude. The basal pressure of the common bile duct was also higher than in controls. These manometric findings may help differentiate the functional papillary stenosis from other causes of the postcholecystectomy pain syndrome and may be useful in settling the question of performing sphincterotomy in these patients.

ISSN:0012-2823    

DOI:10.1159/000198979

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Candida overgrowth in gastric juice of peptic ulcer subjects under therapy with H2-receptor (H2-R) antagonists has been detected in 21.4 and 53.8% of cases after short- and long-term treatment respectively, and in 8 % of controls. Both types of H2-R antagonists, ranitidine and cimetidine, were equally associated with production of yeasts. The location of ulcers, whether gastric or duodenal, seems to have no influence on fungal growth. Females were more susceptible than males to develop Candida in gastric juice. In the short-term course with H2-R blockers fungal colonization of gastric juice was associated with delay of the rate of ulcer healing. Fungal detection in gastric juice was not associated with mucosal invasion by Candida since in none of the patients who had a biopsy for gastric ulcer was Candida detected by histology.

ISSN:0012-2823    

DOI:10.1159/000198980

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The human bile lipoprotein complex includes an apoprotein fraction of IgA fragments and an acidic polypeptide tightly bound to bile cholesterol and phosphatidylcholines. The fate of the intestinal bile lipoprotein complex was immunohistochemically studied. Its localization in the human duodenum is consistent with selective capture or synthesis. The result of both might be the presence of bile apoprotein in the bloodstream. These two mechanisms may explain the cross-reaction between the lipoprotein complex apoprotein and the high density lipoprotein.

ISSN:0012-2823    

DOI:10.1159/000198981

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The role of the adenylate cyclase (Ac)-cAMP system in mediating deoxycholic acid (DOC)-induced fluid secretion was studied in the rat jejunum and colon in vivo using the AC inhibitor, RMI 12 330 A. A potent inhibitory effect of RMI 12 330 A on fluid secretion induced by cholera toxin was demonstrated in ligated rat jejunal loops. On the contrary, the changes of fluid movement in jejunal and colonic loops caused by DOC could not be influenced by RMI 12 330 A, and mucosal cAMP levels of colonic loops were not increased. Colonic mucosal permeability estimated by the ,14C-erythritol clearance increased significantly during a 45-min exposure to 3 mmol DOC, and was not affected by RMI 12 330 A. These results do not support the theory that the AC-cAMP system plays an important role in DOC-induced intestinal fluid secretion and suggest that an increase in mucosal permeability is the predominant factor responsible for the secretagogue effect.

ISSN:0012-2823    

DOI:10.1159/000198982

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The effect of a transpyloric tube on duodenogastric reflux and on gastric emptying was studied in dogs with either an intact pylorus, a Heineke-Mikulicz pyloroplasty, or an extramucosal circular pylorectomy. In fasting dogs, duodenogastric reflux was 10 times smaller than after feeding a liquid lipid meal. A transpyloric tube increased the reflux rate in fasting, but not in fed dogs, while pylorectomy increased reflux rate and intragastric accumulation of a duodenal marker in fed, but not in fasting dogs. It is concluded, therefore, that in the dog (1) methods to measure duodenogastric reflux should not involve the necessity to position a transpyloric tube and (2) the pylorus and adjacent structures are involved in keeping duodenogastric reflux at a low level.

ISSN:0012-2823    

DOI:10.1159/000198983

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The damage of phosphatidylcholine membranes by bile salts such as cholate, deoxycholate (DC), chenodeoxycholate (CDC), ursodeoxycholate (UDC), as well as their glyco- and taüroconjugates, and lithocholate (LC) were studied. The permeabilities of liposomes differing in size (700 and 1,700 Å in diameter) were determined at increasing bile salt concentrations. The release of entrapped raffinose (3H) (MW: 594) or inulin (3H) (MW: 5,000) was measured by pelleting of the liposomes and subsequent determination of the radioactivities in the supernatant. The release of these uncharged volume markers of different size points to a formation of membrane leaks increasing in size with increasing bile salt concentration. Determination of the membrane damaging threshold concentrations of bile salts demonstrated a higher stability of the smaller liposomes. Incubation of the smaller liposomes with increasing DC concentrations results in a successive substitution of lecithin by DC. The predominantly DC-containing vesicles are of remarkable stability against higher DC concentrations. The damaging properties of bile salts increase with decreasing number of hydroxy groups, with the exception of UDC and its conjugates which are much less membrane toxic than the other dihydroxy bile salts. Conjugation with glycine or taurine slightly enhances the membrane toxicity of bile salts with the exception of UDC. Sulfation of the 3-α-hydroxy group of LC reduces the damaging effect to about 1

ISSN:0012-2823    

DOI:10.1159/000198984

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The integrated response of the regulatory peptides of the gastrointestinal tract to a test meal was studied in six hypercholesterolaemic patients who had undergone partial ileal bypass (PIB) and compared with responses in ten age- and sex-matched controls. Plasma motilin was found to rise significantly whereas plasma pancreatic polypeptide release was impaired after PIB. Plasma cholecystokinin rose promptly in both controls and the partial ileal bypass patients, and the latter group showed marked further rises, at 60 and 120 minutes after the meal, which were significantly higher than controls. Basal and postprandial plasma gastrin, gastric inhibitory peptide, neurotensin, enteroglucagon, insulin and pancreatic glucagon were similar in the two groups.

ISSN:0012-2823    

DOI:10.1159/000198985

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Epidemiological studies lend support to the hypothesis that high-fibre diets might prevent and low-fibre diets might facilitate the formation of cholesterol gall stones. In the present study, the bile compositions after ingestion of oat bran 18 g/day and placebo 18 g/day for 2 × 2 weeks were compared in a randomized, double-blind cross-over study in 6 healthy volunteers. The lithogenic index of bile was not influenced, whereas the following changes (0.05 < p < 0.10) occurred: the cholic acid pool was enlarged, the relative proportion of chenodeoxycholate in bile was increased and that of deoxycholate reduced, while cholate remained unchanged. It is concluded that oat bran seems to influence the metabolism of bile acids

ISSN:0012-2823    

DOI:10.1159/000198986

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The delay in diagnosis of 106 patients with adult coeliac disease, diagnosed between 1976 and 1980, was studied. Overall, delay in diagnosis was 11 ± 10.6 years, being considerably greater in females (12.8 ± 7.8 years) than in males (3.5 ± 9.8 years). Most of this delay occurred prior to hospital referral, although that following referral to hospital clinics was still significant (1.8 ± 4.8 years). The most common presenting complaints were lassitude (75%) anaemia (65%) and flatulence (50%). Typical gastro-intestinal symptoms were relatively uncommon and mild, but when present led to a more speedy diagnosis. It is concluded that, despite advances in modern diagnostic procedures, little progress has been made in hastening the diagnosis of coeliac dise

ISSN:0012-2823    

DOI:10.1159/000198987

出版商:S. Karger AG    

年代:1983

数据来源: Karger