摘要:

The aim of the study was to compare the use of cimetidine and colloidal bismuth in the initial healing of chronic duodenal ulcer and to note the recurrence rate over 1 year after healing induced by both forms of treatment. Cimetidine was administered in the dose of 200 mg three times daily and 400 mg at night and the dose of colloidal bismuth was 5 ml four times each day. 51 outpatients with chronic duodenal ulcers proven on endoscopy completed the initial study. At 3 weeks, healing was observed in 83% of the cimetidine group and 70% of the colloidal bismuth group (p > 0.10); at 6 weeks, 96% of patients in both groups had healed. 33 patients were followed up over 1 year, 16 having initially been treated with cimetidine and 17 with colloidal bismuth. 2 other patients originally treated with cimetidine were followed up for 6 months only. No further treatment was given. Endoscopy was performed at 6 and 12 months, or earlier if symptoms developed. At 6 months, 44% of patients in the cimetidine group had recurred compared to 47% in the colloidal bismuth group (p > 0.5). At 1 year, 75% of patients in the cimetidine group and 76% in the colloidal bismuth group had recurred (p > 0.5). It is concluded that both agents are equally effective in healing duodenal ulcers and the incidence of recurrence over 1 year is similar irrespective of whether the initial healing is induced with colloidal bismuth or cimetidine.

ISSN:0012-2823    

DOI:10.1159/000198690

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

In 8 normal subjects the daily administration for 30 days of at least 750 × 106 Streptococcus faecium, a bacteria producing substances acting against Clostridia and other intestinal microorganisms reduced the cholesterol saturation and the molar percentage of deoxycholic acid (DCA) in bile. The percentage of cholic acid (CA) and chenodeoxycholic acid (DCA) increased significantly in feces, whereas lithocholic acid (LCA) decreased from 49.2 to 40.5%. In vitro fecal samples of subjects taking S. faecium transformed more slowly CA to DCA and CDCA to LCA. Moreover, 7-ketolithocholic seems an intermediate step in the biotransformation of CDCA to LCA. During SF administration, the anaerobic bacteria count of feces decreases, whereas aerobic bacteria increase; the changes of fecal flora may reduce the degradation of primary bile acids influencing the bile acid composition in both the bile and the intestine

ISSN:0012-2823    

DOI:10.1159/000198691

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

From 314 patients with coeliac disease, 20 patients were found to have developed a lymphoma. The incidence of lymphoma was much greater in the 6th, 7th and 8th decades of life than in the previous two decades. In 12 patients, the lymphoma was diagnosed within 4 years of the diagnosis of their coeliac disease and there were significantly more of these lymphomas appearing in coeliacs diagnosed between 51 and 80 years, who made up 23% of the series, than in those diagnosed between 21 and 50 years. We conclude that lymphoma is particularly a complication of older coeliacs and that coeliacs newly diagnosed at more than 50 years of age should be more closely followed up for they have a 1 in 10 chance of harbouring a lymphoma.

ISSN:0012-2823    

DOI:10.1159/000198692

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

A possible relationship between α1-antitrypsin deficiency and pancreatitis was studied. Pi phenotype distribution in a group of 90 patients with proven pancreatitis was compared to a control group of 549 randomly selected blood donors. No significant differences were found between the patient group and the controls, nor between acute and chronic forms of pancreatitis. It is concluded that α1-antitrypsin phenotype does not play an important role in pancreatic diseas

ISSN:0012-2823    

DOI:10.1159/000198693

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The action of ethanol on peptic activity in the stomach was evaluated by studying ethanol-induced changes in pepsinogen secretion in the rat in vivo and the effects of ethanol on pepsinogen and pepsin in vitro. Irrigation of the stomach with 3% ethanol in 100 mM HCl plus 50 mM NaCl had no effect on pepsinogen secretion, whereas 10 and 20% ethanol gave maximal increases of about 40 and 65%, respectively. 10% ethanol in 150 mM NaCl (pH 5.0) stimulated pepsinogen secretion maximally by about 60%. 10% ethanol in distilled water had no effect on spontaneous secretion of pepsinogen, but enhanced pepsinogen secretion induced by irrigation of the stomach with 100 mM HCl, 100 mM NaCl, 150 mM sucrose, or by an intravenous injection of carbachol. Ethanol inhibited the activation of pepsinogen to pepsin in vitro in a pH-dependent manner. The activity of pepsin was inhibited by ethanol with an IC50 value of about 10%. The results indicate that the effects of ethanol on pepsinogen secretion and the enzymes, pepsinogen and pepsin, are opposite in the rat. It is thus difficult to conclude what are the net effects of various concentrations of ethanol on the peptic activity of the gastric content, but at least higher concentrations can be expected to reduce this activity.

ISSN:0012-2823    

DOI:10.1159/000198694

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Recently, the demonstration of serum agglutinins to Eubacterium and Peptostreptococcus strains has been found to be useful as a diagnostic test for Crohn’s disease. Therefore, conditions determining the occurrence of these antibodies were studied in patients with Crohn’s disease and ulcerative colitis. Localization of Crohn’s disease in the colon, the presence of fistulae and serum levels of immunoglobulins were found to be contributory determinants for the occurrence of the agglut

ISSN:0012-2823    

DOI:10.1159/000198695

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000193253

出版商:S. Karger AG    

年代:1917

数据来源: Karger

摘要:

90 patients with active duodenal ulcer were admitted to a double-blind trial to compare the effects of pirenzepine (150 mg/daily), cimetidine (1 g/daily) and placebo on the healing of duodenal ulcer. 5 patients did not complete the trial. In 21 of 29 patients (72%) receiving pirenzepine and in 21 of 28 (75%) of those receiving cimetidine, the ulcers had healed after 4 weeks of treatment compared with 10 of 28 (36%) patients receiving placebo (p < 0.01). Symptomatic improvement and reduction of antacid consumption were significantly more marked in the pirenzepine- and cimetidine-treated groups than in the placebo group. Tolerability of drugs was good. The results show that pirenzepine is as effective as cimetidine for the treatment of duodenal ulcer.

ISSN:0012-2823    

DOI:10.1159/000198696

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Lower esophageal sphincter (LES) pressure was measured in 7 cirrhotic patients with massive ascites, before and after paracentesis. The mean LES pressure was 19.8 ± 2.2 SEM mm Hg before and 16.3 ± 1.4 SEM mm Hg after paracentesis (p < 0.05). It is concluded that cirrhotic patients with massive ascites are protected from reflux esophagitis by having an increased LES pressur

ISSN:0012-2823    

DOI:10.1159/000198697

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

A dose-response study of the effect of 0.1–5.0 μg kg-1 h-1 somatostatin was performed on food-induced rise of pancreatic polypeptide and insulin in 4 dogs. There was a dose-dependent suppression of the release of pancreatic polypeptide and insulin with an ED50 of approximately 0.65 and 0.8 μg kg-1 h-1, respectively, during the first 45-min period. In the second 45-min period, high doses of somatostatin failed to suppress insulin concentrations whereas, the serum concentrations of pancreatic polypeptide were reduced by a similar degree as in the first 45 min. The differing effects of somatostatin on food-stimulated serum concentrations of insulin and pancreatic polypeptide indicate that somatostatin does not represent a uniform suppressor of pancreatic hormo

ISSN:0012-2823    

DOI:10.1159/000198700

出版商:S. Karger AG    

年代:1982

数据来源: Karger