摘要:

Fasting serum gastrins were carried out at the beginning and end of a 6-week double-blind trial of cimetidine and placebo in 30 patients with duodenal ulcer. Cimetidine did not cause any significant change in fasting serum gastrin levels after 6 weeks of therapy.

ISSN:0012-2823    

DOI:10.1159/000197999

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In investigations with various groups of patients there was no correlation between fasting serum IRG levels and LES pressures in individual subjects with undisturbed or disturbed sphincters. After food ingestion a short phase of LES pressure increase (from 13.5 ± 1.5 to 21.7 ± 3.8 mm Hg) could be observed. This peak occurs during the phase of rise in gastrin level, but there was no correlation between IRG levels and LES pressure in individual cases. In patients with gastroesophageal reflux we can demonstrate a diminished release of gastrin after a test meal, but there was also a diminished capacity of the LES. In conclusion, in this investigation it has not been possible to show a clear connection in humans between serum IRG and LES functio

ISSN:0012-2823    

DOI:10.1159/000198000

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The effect of the gastric alkaline tide on serum-ionized calcium levels was determined in human subjects. Gastric acid seretion was stimulated by a standard steak meal, human synthetic gastrin, and betazole hydrochloride. Ionized calcium levels fell to a similar extent after each stimulus. The mean decrease in calcium ion concentration in all experiments was 5.4 % of the basal concentration. The fall in serum calcium ion concentration was highly correlated with the rise in serum pH. We speculate that increased formation of calcium bicarbonate complex in the serum as well as increased binding of ionized calcium by serum protein accounts for the surprisingly large effect of the alkaline tide on serum-ionized calcium levels.

ISSN:0012-2823    

DOI:10.1159/000198001

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In a study to determine the most suitable method of expressing activity of jejunal mucosal enzymes, the effect of variation of thickness and protein concentration of biopsies was assessed. Despite wide variation of both these factors, we found no advantage in expressing enzyme activity by reference to either surface area or protein content. Expression of activity by reference to weight of biopsy gave the lowest variance for each of the enzymes studied and, since it is also the easiest measurement to make, it would appear to be the preferred means of expressing jejunal mucosal enzyme activity.

ISSN:0012-2823    

DOI:10.1159/000198002

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The dog jejunum is a much denser tissue than the ileum, with a greater weight per unit length and higher proportion of mucosal tissue. Morphometric analysis reveals longer and wider villi, deeper crypts and larger enterocytes in the jejunal mucosa. Uptake of phenylalanine or β-methyl-glucoside by tissue slices in vitro is slightly greater in jejunal than in ileal tissue. The levels of acid phosphatase and alkaline phosphatase in the individual enterocytes are significantly greater in the jejunum, according to quantitative histochemical analysis. The absorption of water, sodium, potassium, chloride and glucose in vivo is significantly smaller in the jejunal than in ileal loops, particularly when expressed in terms of unit mucosal weight. Sodium and water absorptions are stimulated by glucose at both sites, but the stimulation is significantly greater in the ileum. Opposite results have been obtained in rats where the transport of phenylalanine in vitro is greater in the ileum, but water, electrolyte and glucose absorption in vivo is greater in the jejunum

ISSN:0012-2823    

DOI:10.1159/000198003

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Three cases of benign pancreatic ascites have been added to 94 cases reviewed from the literature. Common characteristics of this syndrome were chronic alcoholism, intermittent abdominal pain, nausea, vomiting and considerable weight loss which occurred despite fluid accumulation. Markedly elevated protein and amylase levels in the ascitic fluid, hyperamylasemia and hypoalbuminemia were the major diagnostic clues as to the pancreatic origin of ascites. Predominant pathological findings were chronic pancreatitis with or without pseudocysts, pancreatic duct disruption, lesions which were considered to be the major pathogenic factor besides lymphatic obstruction by leaking pancreatic juice into the peritoneal cavity. Early laparotomy for diagnosis and treatment is essential. ERP might be of great value in diagnosis.

ISSN:0012-2823    

DOI:10.1159/000198004

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Superfusion of twelve human Taenia Coli strips with cholecystokinin (CCK) (Boots and GIH Karolinska), CCK-octapeptide and glucagon at doses of 25–1,000 mIDu/ml evoked muscular contractions. Dose-dependent response to acetylcholine (ACH) (0.15–1.0 μg/ml) was not altered by an underlying contraction induced by CCK, CCK-octapeptide or glucagon. Though atropine (0.1 μg/ml) abolished ACH effects, hormonal responses were unaffected. The muscle’s sensitivity was highest to CCK (Boots) and lowest to CCK-octapeptide, and the sigmoid colon was more sensitive than other parts of the bowel to both. Addition of glucagon had no effect on CCK-induced (Boots) responses. The results suggest (1) CCK and CCK-octapeptide act directly on the Taenia coli; (2) biologically active impurities in the whole CCK preparations explain their apparent increased activity; (3) glucagon does not block ACH or CCK, nor inhibit, directly, muscle contractions; (4) atropine (0.1 μg/ml) does not interfere with CCK or CCK-octapeptide on coloni

ISSN:0012-2823    

DOI:10.1159/000198005

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The serum α-fetoprotein concentration was measured by radioimmunoassay in 41 women with or without hormonal contraception, 21 patients with rheumatoid arthritis given corticosteroids or not, and 6 patients under androgen therapy for aplastic anemia. None of these therapies induced any significant variation of the serum α-fetoprotein level. More extensive studies are needed to investigate the possible effect of these hormones on the metabolism of this protein at a cellular leve

ISSN:0012-2823    

DOI:10.1159/000198006

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198007

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198008

出版商:S. Karger AG    

年代:1977

数据来源: Karger