摘要:

Four series of duodenal ulcer patients presenting with pain have been treated with two types of placebos (intramuscular injections or tablets) by 4 different physicians while a fifth group of patients did not receive any treatment. Patients noted the number of days with pain since the beginning of the test by themselves. All patients treated with placebo presented with a significantly shorter duration of pain than untreated patients. There was a significant difference between the actions of the different physicians on the duration of pain. This suggests that some, until now unprecised, character(s) of the physician plays an important part in the relief of duodenal ulcer pain.

ISSN:0012-2823    

DOI:10.1159/000198080

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The amount of immunoglobulin-containing cells in gastric mucosa from 6 patients with Ménétriér’s disease was estimated. Furthermore, the rate of gastric epithelial cell proliferation was studied in 4 of the patients. Fluorescent antisera specifically reacting with IgA, IgG and IgM were applied, and accordingly the cells were differentiated and quantitated. Other biopsies were labelled in vitro with 3H-thymidine and autoradiographs were prepared. The percentage of DNA-synthesising cells in the progenitor cell region was estimated. The number of IgM-containing cells in the gastric fundic mucosa was markedly increased, while the rate of epithelial cell proliferation was increased in 2 cases and within normal range in the remaining 2 pati

ISSN:0012-2823    

DOI:10.1159/000198081

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

134 patients with radiolucent gallstones were randomly allocated to receive either placebo or 1 of 3 different doses of chenodeoxycholic acid (CDCA); 750, 1,500, or 3,000 mg). The initial dose was lowered if not well tolerated. 107 patients were treated for more than 3 months. Among them, stones dissolved in 21 and were smaller in 25 patients. Partial or complete dissolution occurred in 4 of the 13 receiving 375 mg/day, 14 of 37 receiving 750 mg, 24 of the 38 receiving 1,500 mg and 4 of 8 receiving 3 000 mg/day. The number of responders to the therapy was significantly greater in the groups of patients receiving 1,500 mg/day or 17–24 mg/kg body weight than in any other group. However, side effects, i.e., diarrhea and transaminase increase, are also dose related. It appears from this study that the optimal dose of CDCA may be between 17 and 20 mg/kg body weigh

ISSN:0012-2823    

DOI:10.1159/000198082

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The maximal tolerated dose of chlorobenzilate was given by continuous oral administration, starting at the age of 7 days, to both sexes of two hybrid strains of mice -(C57BL/6 × C3HAnf)F1 and (C57BL/6 × AKR)F1. There was an increased incidence of tumors in one or more organs in male mice of both strains and female mice of the (C57BL/6 × C3HAnf)F1 strain. Male mice of both strains developed significantly elevated incidences of carcinomas of the liver. Female (C57BL/6 × C3HAnf)F1 strain mice had a significantly increased incidence of hyperplasia and carcinomas of the forestom

ISSN:0012-2823    

DOI:10.1159/000198083

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198084

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198085

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198086

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198087

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191807

出版商:S. Karger AG    

年代:1910

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191808

出版商:S. Karger AG    

年代:1910

数据来源: Karger