摘要:

Correlations between nutrition and the frequency of acute and chronic pancreatitis, respectively, have been studied in 24 centres in 16 countries in Africa, Latin America, Asia, and Europe. In these countries, consumption of ethanol, fat, proteins, and carbohydrates varies from the lowest to the highest rates. It appears that the geographical distribution of chronic calcifying pancreatitis can be linked with alcoholism, especially in countries with a high-protein, high-fat diet. It also has a high incidence in countries where there is malnutrition (primarily in the form of protein deficiency): the disease occurs in these areas at an early age.

ISSN:0012-2823    

DOI:10.1159/000197468

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Within the last 10 years, 102 cases of chronic pancreatitis have been observed, indicating that the incidence of chronic pancreatitis in Zurich is much higher than previously claimed. 84% of our patients are male with an average age of 43 years at onset. Pancreatic calcifications were demonstrated in 63%. Chronic alcoholism occurs in 62% of all patients. In our experience, ‘acute pancreatitis’ in chronic alcoholics is almost always the first manifestation of chronic relapsing pancreatitis, which is detected on the average 5 years after the first pain episode. Pancreatic exocrine insufficiency demonstrated by the CCK-secretin test was found in 99% of the patients tested, steatorrhea in 72%, and clinical or subclinical diabetes in 83%. 29 of the 102 patients died during the average follow-up time of 8.6 years. Death was due to complications of pancreatitis in about 30%. 35% of all patients were operated on for complications or for severe pain. But 36% of patients with chronic relapsing pancreatitis became painless spontaneously (‘secondary painless’ pancreatitis) after an average period of 6.6 years. In patients with ‘secondary painless’ pancreatitis, severe pancreatic insufficiency is predominantly present, indicating that chronic pancreatitis has the tendency to ‘burn out

ISSN:0012-2823    

DOI:10.1159/000197469

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

On the basis of 263 male cases of primary chronic pancreatitis from western France, the following factors were analyzed: (1) distribution of the cases according to geological characteristics; (2) data on age, occupation, history, and especially the dietary habits of these patients, stressing the frequency of obesity, excessive food intake, and alcoholism and (3) definition of the course of the disease. The following points were examined: (1) the general profile of pain in the evolution over 15 years; (2) study of some courses which the disease may take (remission of clinical cure, complications, cirrhosis, death); (3) the patient’s condition during the 15 years of illness (weight, disturbance of carbohydrate metabolism, ability to work), and (4) factors influencing the course of the disease (age, pancreatic calcification, alcohol intake, and surgery

ISSN:0012-2823    

DOI:10.1159/000197470

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Alcohol abuse was observed in 32.9% of 150 collected patients with calcifying pancreatitis (male/female ratio 3.5:1.0; average age: 45), while no etiology was found in 41.5% of them. The comparison of occupation, cigarette smoking, daily intake of alcohol and food was made between age-matched groups of calcifying pancreatitis and pancreatic carcinoma. Only the frequency of alcohol intake was significantly higher in pancreatitis than in pancreatic carcinoma.

ISSN:0012-2823    

DOI:10.1159/000197471

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000188150

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

99 patients with pancreatitis are discussed, 95 of whom had pancreatitis induced by cane spirits. One quarter of the patients had pancreatic calcification (more Indians than Africans) and 13% had pancreatic pseudocysts (32% Indians, 6% Africans). Over 50% of the African patients were in the lower dietary group, consuming meat less than twice weekly. Pancreatic function tests (secretin-cholecystokinin) disclosed a low bicarbonate and amylase secretion in 84 patients and a lowered concentration associated with a large volume of secretion in 15 patients. Triple-lumen intestinal perfusion with sucrose or glucose revealed a diminished absorption of both sugars in pancreatitis with diabetes and other groups tested. Water and sodium absorption were increased, and potassium secretion was increased in pancreatitis with diabetes.

ISSN:0012-2823    

DOI:10.1159/000197472

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A review of 1,006 patients studied over a 12-year period underlines the importance of alcohol in calcific, chronic and, to a lesser extent, acute pancreatitis. The racial incidence, natural history and complications of calcific pancreatitis are presented and genetic data discussed. Recognition of a pre-calcific state based on tests of endocrine and exocrine function is suggested.

ISSN:0012-2823    

DOI:10.1159/000197473

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000188151

出版商:S. Karger AG    

年代:1903

数据来源: Karger

摘要:

The pathology of 86 cases of chronic pancreatitis derived from autopsy and surgical sources in Cape Town is outlined. These cases show no definite predisposition to any of the ethnic groups occurring in this region, males are involved more frequently than females, and the majority occur in the age group 31–60 years. A severe form of advanced chronic pancreatitis in which a constant histological picture characterised by lobular destruction, perilobular fibrosis, ductal dilatation and ductal plugging by proteinaceous material, occurs in 77.8% of cases. Although calcification occurs in only 48% of these cases the overall picture corresponds to the entity of chronic calcine pancreatitis. A strong history of chronic alcoholism is present in 62% and evidence of biliary disease in only 8

ISSN:0012-2823    

DOI:10.1159/000197474

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000188152

出版商:S. Karger AG    

年代:1903

数据来源: Karger