摘要:

Mean fasting levels of pancreatic polypeptide (PP) in 24 patients with Zollinger-Ellison syndrome (ZES) and in 12 patients with hyperparathyroidism originating from families with multiple endocrine adenomatosis type I (MEAI-HPT) were significantly higher than in 72 normal controls. The overlap between the 3 groups, however, was large. In patients with ZES, increased PP levels were not related to the presence of MEAI or metastases; nor was there a correlation between serum PP and gastrin concentrations. The post-prandial PP release in 10 ZES patients and in 10 patients with MEAI-HPT was lower than in 9 normal controls. The physiological significance of the present findings is unclear.

ISSN:0012-2823    

DOI:10.1159/000198216

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Stress was measured by the frequency of 31 major life events with consequent change and distress scores in 50 patients with chronic gastric ulcer and 50 control subjects, matched for age, sex and place of residence. The gastric ulcer population did not differ from the control population regarding the number of events experienced and the associated change and distress scores. However, when analysed according to social grade, the ulcer patients in the lower status suburbs experienced more events and more change than their controls, but the distress scores were similar. In the higher status suburbs, no difference was present between the patients and controls. Change and distress scores rose progressively with age, but there was no significant difference in the number of events experienced between the three age groups. Both men patients and their controls experienced significantly more events and higher change scores than women patients and their controls.

ISSN:0012-2823    

DOI:10.1159/000198217

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Secretion patterns of gastric lipase and pepsin were studied in duodenal ulcer patients before and after vagotomy and in healthy subjects following continuous administration of pentagastrin in graded doses. The lipase output increased in response to pentagastrin stimulation in similar fashion as that of pepsin. The output of the two enzymes were correlated with each other and with hydrogen ion output. Evaluation of dose-response relationships showed that in duodenal ulcer patients the secretion of gastric lipase and pepsin is more sensitive to pentagastrin stimulation than that of hydrogen ions.

ISSN:0012-2823    

DOI:10.1159/000198218

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The age-dependent constituents of esophageal acidic glycosaminoglycans (AGAG) were studied using 35 healthy individuals by electrophoretic characterization and enzymic assay with specific chondroitinases and hyaluronidase. Human esophageal AGAG comprised hyaluronic acid, dermatan sulfate, heparan sulfate and chondroitin 4- and 6-sulfate and oversulfated dermatan sulfate. Hyaluronic acid was the major part of AGAG at the young age but it decreased definitely with the advance of age. The proportion of dermatan sulfate and the oversulfated isomer to total AGAG significantly increased until adult age and then tended to somewhat decrease with increasing age. The proportion of heparan sulfate consistently increased with the advance of age.

ISSN:0012-2823    

DOI:10.1159/000198219

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Intestinal absorption after extensive small bowel resections, for diseases other than Crohn’s disease, was studied in 17 patients. When the ileocecal valve and the right colon were preserved, malabsorption was transient and moderate and had no prejudicial nutritional effect (fecal fat: 8.8 ± 1.8 g/24 h in resections sparing the 2 distal bowel loops, and 16.2 ± 4.8 g/24 h in resections including the distal ileum; mean ± SEM). When colectomy was associated, malabsorption was severe and persistent (fecal fat: 47.4 ± 12.2 g/24 h; mean ± SEM). These findings suggest that the most important prognostic factor in extensive small bowel resection is the site of the resection, and particularly the presence or absence of the right colon and ileocecal

ISSN:0012-2823    

DOI:10.1159/000198220

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The relationship between the average daily intake of alcohol and the risk of developing chronic pancreatitis was studied in two surveys, one in Marseille (France), the other in 9 centers, in Caucasian-populated countries. In the latter survey, the interactions between alcohol, protein and fat consumption and the risk of chronic pancreatitis have also been statistically analyzed. These studies were performed with hierarchical log-linear models for contingency tables, the relative odds being taken as an approximation of the relative risk. It has been shown that there is no apparent threshold of toxicity of alcohol on the human pancreas. The logarithm of the relative risk of chronic pancreatitis increases linearly as a function of the quantity of alcohol and protein consumed, and varies quadratically as a function of average daily lipid intake (a low- or high-lipid diet increases the risk of developing chronic pancreatitis in comparison to an average-fat diet (85–110 g fat per day). The effects on log-relative risk of alcohol, fat and protein daily consumption are additive. In Marseille, the average duration of alcohol consumption before the appearance of symptoms is 18 ± 11 years for males and 11 ± 8 years for females, which is much shorter than the duration of alcohol consumption before onset of symptoms in cirrhotic patie

ISSN:0012-2823    

DOI:10.1159/000198221

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

5 human cases of hepatoma have been chosen with respect to their different seric α-fetoprotein (α-FP) level and histological characters. Cells producing α-FP have been studied with specific horseradish-peroxidase-labelled immunoglobulins. Ultrastructural examination shows that α-FP is present in the cytoplasm of some tumoral hepatocytes. α-FP is also present in the cytoplasm of some rare nontumoral hepatocytes of a nonsecreting hepatoma. Ultrastructural differences are described in tumoral hepatocytes according to the grade of differentiation of the tumoral cell population. α-FP production appears to be restricted to moderately differentiated tumoral hepatocytes. These observations led to the hypothesis that production of α-FP may transiently develop either during the differentiation of tumoral hepatocytes, or during the new differentiation of nontumoral hepatocytes involved in a proliferatíve

ISSN:0012-2823    

DOI:10.1159/000198222

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

CH50 and the concentrations of C3, C4, C1 INH and factor B have been measured in sera from 34 control subjects and 178 patients with various hepatobiliary diseases, including primary biliary cirrhosis (PBC), chronic active hepatitis (CAH), cryptogenic cirrhosis (CC), alcoholic liver disease (ALD), Wilson’s disease (WD), large duct biliary obstruction (LDBO) and viral hepatitis (VH). CH50 was decreased in CAH and CC. C3 was increased in PBC, LDBO and VH and decreased in CAH and CC. C4 was decreased in PBC, CAH, ALD and WD. C1 INH was increased in PBC, CAH, ALD, LDBO and VH. Factor B was increased in LDBO and VH and decreased in CC. In none of the patient groups was the mean C4 level increased or the mean C1 INH level decreased. All 5 indices of serum complement were lower in ascitic than nonascitic patients. Data on serum complement were similar in HBsAg positive and negative VH. Discriminant analysis facilitated separation of all the patient groups on the basis of complement data, except PBC and VH. Analysis of data using a within-group correlation matrix revealed a significant negative correlation between C4, the most discriminating variable of serum complement in CAH, and γ-globulin concentration in CAH. The possible contribution of factors such as activation of complement, impaired hepatic synthesis of complement components, an acute phase response and cholestasis to altered serum complement profiles in different hepatobiliary diseases is discuss

ISSN:0012-2823    

DOI:10.1159/000198223

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effect of somatostatin on the pancreatic exocrine response to different doses of exogenous stimuli and the somatostatin dose-response relationships on pancreatic secretion were studied in conscious dogs. Somatostatin caused a strong inhibition of basal or slightly stimulated pancreatic secretion but failed to inhibit the maximal responses, suggesting that somatostatin interacts with secretin or caerulein by a competitive mechanism. A higher maximal percentage of inhibition and a dose-response relationship was observed with protein outputs and enzyme concentrations. Volumes and bicarbonate outputs were also inhibited but the maximal percentage of inhibition was lower.

ISSN:0012-2823    

DOI:10.1159/000198224

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The levels of the proenzymes trypsinogen and chymotrypsinogen were studied in guinea pigs with pancreatitis induced by injection of sodium taurocholate containing the antibiotic cephalothin. This treatment inhibited the enzyme activities and prolonged the activation times of the proenzymes. Both trypsinogen and chymotrypsinogen content decreased after induction of pancreatitis, but there were no significant changes in the proenzyme contents in relation to injection-to-excision times. Sodium taurocholate and cephalothin were cleared from the pancreas in 2 h. Administration of chlorophylla together with the inducer caused a slight increase in proenzyme levels.

ISSN:0012-2823    

DOI:10.1159/000198225

出版商:S. Karger AG    

年代:1978

数据来源: Karger