摘要:

The diagnostic value of the fecal chymotrypsin test (FCT) was reevaluated with regard to (a) proved pancreatic hypofunction of different severity (183 pancreozymin-secretin tests); (b) the final clinical diagnosis, and (c) fecal fat excretion (208 patients with chronic pancreatitis; CP). Progressive pancreatic disease (cancer, CP) was mainly associated with moderate or severe pancreatic hypofunction (119/138; 86.2%) and a low incidence of false-normal FCT values (14/138; 10.1%). Miscellaneous disorders (mainly reversible pancreatic hypofunction) were mainly associated with slight pancreatic hypofunction and a high incidence of false-normal FCT values (17/45; 37.8%). Pancreatic steatorrhea ( > 10g/day) was found only in patients with markedly depressed FCT values. Progressive deterioration of pancreatic function was demonstrated by repeated FCT in CP (n = 220).

ISSN:0012-2823    

DOI:10.1159/000198578

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Administration of cholic acid (1.0% of the diet) to male Fisher rats for 3 days resulted in increased numbers of DNA synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed rats. The middle third of the crypt was the area stimulated to contribute the additional proliferating cells. The maximum number of 3H-TdR-labeled cells was doubled by 24 h and migration had proceeded further up the colonic crypt of the 1 % cholic acid-fed rats than the 0.2% cholic acid or control animals. Compared with cholic acid-deprived rats, long-term dietary intake of 0.2% cholic acid (26 weeks) was found to heighten the numbers of labeled cells per column and expand the prolif-erative compartment. The enhanced manifestation of colonic neoplasia in MNU-induced rats consuming cholic acid (previously reported by us) appears related to the elevated levels of cell proliferation brought about in response to the deleterious action of the bile acid on the mucosa. Increased numbers of epithelial cells undergoing DNA synthesis in cholic acid-treated animals would allow the earlier expression of malignant transformation in the large intestine.

ISSN:0012-2823    

DOI:10.1159/000198579

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Enzymatic sulphation of bile salts was identified in cytosol prepared from human adrenal tissue. Unconjugated lithocholate was sulphated at a slightly greater rate than glyco-lithocholate. Chenodeoxycholate and deoxycholate were sulphated at the 7- and 12-OH positions, respectively, but no disulphate formation from these bile salts was found. The physiological implications of these results are discussed.

ISSN:0012-2823    

DOI:10.1159/000198580

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

9 patients with achlorhydria and hypergastrinemia and 8 control patients with normal gastric H+ secretion and normal serum gastrin level were studied before and after a mixed liquid test meal. Mean plasma gastric inhibitory polypeptide increased to significantly higher values in the achlorhydric group than in the control group 30, 60 and 90 min after the meal. In the achlorhydric group mean serum gastrin fell significantly below the basal level 60 and 90 min after the meal, whereas a significant increase was observed in the control group.

ISSN:0012-2823    

DOI:10.1159/000198582

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Serum prednisolone levels have been measured following the oral administration of 20 mg prednisolone in 10 normal subjects, in 9 patients with Crohn’s disease and in 6 with coeliac disease. Serum prednisolone levels showed more variation in patients with Crohn’s disease when compared to normal subjects. In those patients with Crohn’s disease who failed to respond to corticosteroid therapy, adequate serum levels of prednisolone were achieved. Patients with coeliac disease had levels similar to normal. Serum protein binding of prednisolone was not significantly different between the groups. We conclude that, even in the presence of mucosal damage, patients with coeliac disease and Crohn’s disease achieve therapeutic serum prednisolone

ISSN:0012-2823    

DOI:10.1159/000198583

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effect of the topical corticosteroid clobetasone butyrate on enzyme activity and morphology of duodenal mucosa was studied in 9 patients with coeliac disease and 10 controls using organ culture techniques. There was significant increase in mucosal alkaline phosphatase, lactase and maltase activities, but inclusion of a soluble extract of gluten reduced this effect. When clobetasone butyrate was also included in the culture medium significant elevations in enzymes were again observed. Enterocyte height was not affected by incorporation of gluten into the medium. Intra-epithelial lymphocyte counts fell significantly during the culture period. This improvement was also inhibited by gluten and overcome by addition of steroid.

ISSN:0012-2823    

DOI:10.1159/000198584

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198585

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198586

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198587

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000193180

出版商:S. Karger AG    

年代:1915

数据来源: Karger