摘要:

Gastric emptying of a test meal labelled with 99Tcm-sulphur colloid has been studied in 9 healthy volunteers using a gamma-camera with on-line computer. Mean transit time (MTT) was determined by fitting the time-activity histogram to a gamma-variate, and the half-time of emptying (T½) was calculated by exponential fitting of the down-slope of the time-activity curve. MTT showed a smaller coefficient of variance than T½ This result suggests that MTT may be a more suitable parameter for definition of normal values and for the separation of normal from pathological patterns of emptyin

ISSN:0012-2823    

DOI:10.1159/000198024

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

When gastric cancer patients’ leucocytes were exposed to a panel of tumour extracts, leucocyte migration reactivity was ‘positive’ before operation (90% of cases), it declined after surgery and it reappeared in patients with local recurrence or metastases. In patients with non-malignant gastric diseases, ‘positive’ reactivity against tumour extracts was associated almost exclusively with atrophic gastritis with and without intestinal metaplasia (24/43 cases). ‘Positive’ patients also showed a pathological migration index with an extract of normal g

ISSN:0012-2823    

DOI:10.1159/000198025

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

During infusion of caerulein, the output of γ-glutamyl transpeptidase and biliary alkaline phosphatase is significantly more increased in chronic pancreatitis patients than in normal subjects. The presence of the gall-bladder is necessary to observe this effect of caerulein. It is not related to the discharge of large amounts of both enzymes by the diseased pancreas

ISSN:0012-2823    

DOI:10.1159/000198026

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The form in which copper is bound in bile was studied in bile from patients with Wilson’s disease, control subjects and rats. Bile was labelled with 64Cu. Sephadex column chromatography using gels G-200-G-10 showed a major 64Cu and protein peak of about 5,000 daltons and a minor peak of about 8,000 daltons. A high-molecular-weight peak (above 800,000 daltons) which was present when the eluting solution consisted of water or saline was shown to be an artefact which could be abolished by the addition of bile salt to the eluting solution. Bile from control subjects, Wilson’s disease patients and from the rats behaved in the same manner binding copper to low-molecular-weight proteins. The relationship of these findings to the pathogenesis of copper retention in Wilson’s disease is disc

ISSN:0012-2823    

DOI:10.1159/000198027

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In a series of experiments in rats, the movement of the advancing sheet of epithelial cells streaming from the border region into the wound bed of standardized defects in the glandular mucosa of the stomach was studied using the light microscope and the scanning electron microscope (SEM). A very high synthetic activity of mucus in gastric lining cells of the border region (with a typical shift in its reaction product towards a more acidly reacting product showing metachromasia with toluidine blue) was observed histochemically, together with a loss of characteristic features of glandular cells in the border region with an increase in mitotic activity. The SEM images enabled a detailed analysis of the advancing epithelial front in its relation to the border regions. Considerable local differences were noted in the moving pattern of the migrating epithelium, possibly in relation with the nature of the base on which it has to move. The lesion of 3 mm diameter appeared to close usually after 10 days; in some instances, however, small epithelial defects were later found which could easily be traced with the SEM.

ISSN:0012-2823    

DOI:10.1159/000198028

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Isotonic solutions of substrate were infused into surgically prepared sacs of upper small intestine in conscious unrestrained rats which fed normally via the gut-in-continuity. Infusion of glucose, galactose or sodium chloride all caused a local increase in villus height, while α-methyl glucoside and mannose had no effect. Glucose, galactose and α-methyl glucoside all stimulated a similar increase in counts of vincristine metaphases in microdissected crypts, although the absolute level of cell production was lower throughout the gut in glucose-infused rats. Sodium chloride infusion also caused a small stimulation of cell production locally, but a considerable increase in the uninfused gut-in-continuity. Mannose infusion had a variable effect on cell production. These results do not support ‘luminal nutrition’ as a controller of epithelial replacement in the rat small intestine, and suggest that a mechanism based on the work-load of the epithelium may be more approp

ISSN:0012-2823    

DOI:10.1159/000198029

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Male Wistar rats, fed a standard normal laboratory diet, drank ad libitum a 20% ethanol solution for 3 months. Basal and 2-deoxy-D-glucose (2DG) stimulated pancreatic secretion were measured. Basal secretion of sodium (-30%, p < 0.001), bicarbonate ( 35%, p < 0.001) and total protein ( 35%, p < 0.001) were depressed in alcoholic versus control rats. Pancreatic response was identical in both groups with the smaller dose of 2DG, dose related in controls, and identical for both doses in alcohol-fed rats. The response was thus significantly smaller in alcohol-fed rats than in controls for the larger dose of 2DG (p < 0.01). Pancreatic concentration and contents of amylase, trypsinogen, chymotrypsinogen and lipase were all decreased in alcoholic versus control rats (40–60%, p < 0.001). These results are consistent with the hypothesis of functional modifications in pancreatic cholinergic innervation in alcohol-fed rat

ISSN:0012-2823    

DOI:10.1159/000198030

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000198031

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

After days of standardized conditions of life and standardized diets, serum gastrin levels were measured in 6 patients with liver cirrhosis on 3 consecutive days and in 14 normal controls on 1 day. Blood samples were drawn every 4 h. In patients as well as in controls, a significant serum gastrin circadian rhythm was noted. The daily mean serum gastrin levels of patients were not significantly different from those of controls. These results suggest a secondary role of the liver in gastrin metabolism.

ISSN:0012-2823    

DOI:10.1159/000198032

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Cimetidine inhibited nocturnal secretion of acid but only slightly inhibited the nocturnal secretion of pepsin in patients with duodenal ulcer. Administration of cimetidine (200 or 400 mg), together with an anticholinergic drug (poldine), augmented the inhibition of the nocturnal secretion of acid and of pepsin. The combination of an H2-receptor-blocking drug with an anticholinergic drug will have therapeutic application in the management of duodenal ulceration.

ISSN:0012-2823    

DOI:10.1159/000198033

出版商:S. Karger AG    

年代:1977

数据来源: Karger