摘要:

Acidification of the duodenum of healthy young subjects with 40 mEq of acid during 1 h resulted in a 45-percent inhibition of acid output in response to 0.15 μg/kg/h of pentagastrin, but had no effect on acid output stimulated with 6.0 μg/kg/h of pentagastrin. There was no significant effect of duodenal acidification on the total output of pepsin. Since secretin stimulates pepsin secretion, endogenous secretin alone cannot account for the inhibition of acid secretion. Duodenal acidification with the subjects own gastric acid had no significant effect on gastric secretion. The physiological significance of the effects described seems, therefore, uncertai

ISSN:0012-2823    

DOI:10.1159/000197238

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The Ouchterlony technique, single radial immunodiffusion and fluoro-electro-immunodiffusion (FEID) for the detection of α-fetoprotein (AFP) had their own merits. FEID was at least 30 times as sensitive as the Ouchterlony technique for the detection of serum AFP. Its great sensitivity elicited a positive reaction in sera which were previously negative by the Ouchterlony technique

ISSN:0012-2823    

DOI:10.1159/000197239

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

We have previously demonstrated that β-3-thienylalanine (β3TA), an analogue of phenylalanine, inhibits zymogen granule formation in pancreatic acinar cells in rats. That such inhibition of zymogens might prevent drug-induced pancreatitis was studied in the experimental model of ethionine pancreatitis. 14 Sprague Dawley rats were divided into 2 groups. Group I was given a maintenance amino acid diet for 3 days and then a diet containing equimolar substitution of ethionine for methionine for 8 days. Group II received this same diet but with a 3 × equimolar substitution of β3TA for phenylalanine for 3 days, followed by a 1 × equimolar substitution for 8 days while on ethionine. The animals were killed and tissues prepared for microscopic examination. Group I rats demonstrated severe pancreatitis; group II showed few such changes. Another study was done in identical manner with rats being killed 3 days after initiation of ethionine feeding. Engorgement of acini with zymogens and early pyknosis appeared to precede the development of pancreatitis in rats not receiving β3TA. Rats receiving this analogue showed complete zymogen suppression and no pancreatitis. A 9 × equimolar dose of β3TA administered over a 24-hour period was fatal to rats receiving such high concentrations. β3TA may prevent ethionine pancreatitis through its zymogen suppressiv

ISSN:0012-2823    

DOI:10.1159/000197240

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Follow-ups of 4 cases of chronic hepatitis are presented, in whom the serum alkaline phosphatase activity was increased 3 to 9 times more than the upper normal limit. Evidence for an intrahepatic cholestasis was not found. Cholesterol and bilirubin levels in the sera were normal. The bile ducts were visible radiologically in 3 of the 4 cases. No histologic evidence was found for an alteration of the bile ducts. In 3 cases the alkaline phosphatase activity decreased, becoming normal along with the transaminases and remission of the histologically verified inflammation in two studied cases. Evidence for the hepatic origin of alkaline phosphatase in the sera of patients with liver diseases was discussed. In liver diseases with high activity of alkaline phosphatase in the serum without hyperbilirubinemia not only liver metastases and early stages of primary biliary cirrhosis must be considered but also non-cholestatic chronic hepatitis.

ISSN:0012-2823    

DOI:10.1159/000197241

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197242

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197243

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197244

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197245

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197246

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197247

出版商:S. Karger AG    

年代:1972

数据来源: Karger