摘要:

The loss of plasma proteins into the gastrointestinal tract was assessed by the usual 51Cr albumin or 131I polyvinyl-pyrrolidone method in 9 patients with RA and 3 patients with PSS. In all these patients, the amounts of albumin excreted over a 4-day period were within the range of normal. Thus, no protein-losing enteropathy was demonstrated in this group of patients.

ISSN:0012-2823    

DOI:10.1159/000197177

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The response of the jejunal villous epithelial cell and its subepithelial tissues to a single dose of gluten was studied with the electron microscope in 3 coeliac patients treated with a gluten-free diet for 3 years or more and compared with that of a non-coeliac child. Up to 48 h after gluten administration the epithelial cells of the coeliac patients showed no abnormality but the subepithelial basement membrane was thickened, the capillary endothelium showed swelling and there was an increased infiltration of lymphccytes, eosinophils and plasma cells in the intercellular and subepithelial spaces. Epithelial damage was seen at 96 h after gluten in only one of 2 patients. The ultrastructural changes in the non-coeliac child 24 h after gluten were entirely confined to the epithelial cell itself and consisted of large intracytoplasmic vacuoles, lined by smooth membranes which contained fibrous and other unidentifiable material. The absence of an intracellular reaction at least in the early stages following gluten in the coeliac patients could be due to an ineffectiveness in walling-off exogenous material such as gluten and may be of importance in allowing antigenic material to pass through the cell thus setting up immunological reactions in the subepithelial connective tissue and nearby capillary endothelium.

ISSN:0012-2823    

DOI:10.1159/000197178

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The response of the digestive tract after ingestion of milk in lactase insufficiencies was investigated by X-ray. In subjects with lactose intolerance after milk the gastric evacuation is retarded, while there is a considerable simultaneous increase in the transit time through the small intestine. There is also an increased secretion in the small intestine. In the colon, pneumatosis starts from the moment the contrast substance reaches the caecum. These changes are not found after administration of lactose-free milk, where the findings are similar as in controls.

ISSN:0012-2823    

DOI:10.1159/000197179

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Au/SH Antigen was detected in the blood of 4 patients with a clinically typical and histologically proved periarteritis nodosa. The Au/SH antigenemia can be precocious and seem to persist constantly at a high level in all cases. Initial exposure notion to hepatitis virus was present 3 times. Clinical hepatic manifestations initiated the disease in 2 cases and were absent in 1. Association between Australia antigen and periarteritis nodosa (PAN) deserves emphasis and the correlation with similar observations reported by Gocke is a confirmation. A filiation between hepatitis and polyarteritis induced by the same virus is suggested.

ISSN:0012-2823    

DOI:10.1159/000197180

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The line of investigations which have led to the physicochemical characterization of the complex bile salt/lecithin/cholesterol in bile, is reminded. The near saturation level of cholesterol, in normal human bile, is a probable factor in the frequent build-up of cholesterol gallstones. Studies on experimental cholelithiasis in laboratory animals yet have not clarified the actual conditions that initiate the process in man. The interest of procedures, which might facilitate direct access to parameters of the intact enterohepatic circulation, is stressed. A review is made of studies on the bile acid composition of bile, and of interpretations of the presence of minor components. Lithocholic acid, among the latter, deserves a special mention, in view of a marked liver toxicity demonstrated in laboratory animals. Recent progresses in the field of analytical methodology for bile acids are mentioned. The significance for clinical chemistry of blood levels of bile acids is envisaged.

ISSN:0012-2823    

DOI:10.1159/000197181

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197182

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197183

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197184

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197185

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000187735

出版商:S. Karger AG    

年代:1899

数据来源: Karger