摘要:

Gastric secretory function was studied for 24 h in rats bearing permanent gastric fistulas and permanent intra-venous cannulas. Rats were fed normal, fat free and rich fat diets for three months prior to collection of gastric content. Saline or histamine in saline were infused intravenously for 24 h during the collection period. Feeding fat rich diet induced the significant depression of histamine stimulated gastric secretion.The absence of normal post-histaminic increase of gastric secretory function in ratsfed fat rich diet is considered due to “work hypoplasia”, resulting from prolongedand repeated inhibition of secretory function of parietal ce

ISSN:0012-2823    

DOI:10.1159/000196914

出版商:S. Karger AG    

年代:1969

数据来源: Karger

摘要:

The protective action of protease inhibitors (Trasylol, IP-315) the synthetic antifibrinolytic agent (EACA) and heparin in the prevention of acute pancreatic necrosis was evaluated on the basis of serum amylase, histological examination and survival of dogs. Heparin was found to be the most efficient agentin protecting dogs from pancreatic necrosis, the other protease inhibitors were much less effective.In dogs pretreated with heparin no elevation of fibrinogen level and no inhibition of fibrinolysis were observed. These changes were markedly expressed in control dogs with pancreatic necrosis and those receiving profease inhibitors. The total proteolytic activity of pancreas homogenates was investigated. A significant difference in the heparin-treated dogs in comparison with the controls was observed. Similar differences were obtained on testing acid phosphatase in both groups. Successful prevention of acute pancreatitis by heparin can also be explained as being due to the anti-clotting properties of this drug as well as to its action on the level of the pancreatic cell. It is also possible that heparin has a stabilizing effect on lysosomes, known to be the main source of hydrolases.

ISSN:0012-2823    

DOI:10.1159/000196915

出版商:S. Karger AG    

年代:1969

数据来源: Karger

摘要:

In a total of 18 cases with advanced liver cirrhosis enteral protein loss was tested by the PVP-J131 method. In two cases enteral PVP-J131 excretion was markedly abnormal, four other patients had values above normal. The two cases with increased excretion of PVP-J131 showed in peroral biopsy specimens of intestinal mucosa lymphangiectasia and cell infiltration. Portal hypertension and disturbed outflow of lymph in liver cirrhosis are discussed as possible causes for enteral protein loss.

ISSN:0012-2823    

DOI:10.1159/000196916

出版商:S. Karger AG    

年代:1969

数据来源: Karger

摘要:

Three weeks after transection of the intestine and resection of half the small intestine respectively in rats hypertrophic mucosal changes were assessed quantitatively.It was revealed that after resection (and to a small extent also after transection alone) the mucosal areao f the stump increases due to prolongation of the villi and a slight increase of the diameter of the intestine but not as a result of longitudinal intestinal growth. The increase is greatest in the ileum whereby the area of the mueosa per unite of length of intestine is even greater than the values recorded in the jejunum. Thus a reverse distal-proximal gradient of the intestinal absorption surface develops. The increase of the area of the mucosal surface correlates relatively closely with the prolongation of the villi. Between the experimental groups no differences were found in the number and mutual ratio of enterocytes and goblet cells.From the results of assessment of the mucosal area it is apparent that three weeks after resection of half of the intestine the absorption surface roughly doubles and reaches the original area.

ISSN:0012-2823    

DOI:10.1159/000196917

出版商:S. Karger AG    

年代:1969

数据来源: Karger

摘要:

Peroral jejunal biopsies were performed in both clinically asymptomatic parents of 15 children with c.s. Histological, histochemical and biochemical exanimation revealed various alterations in 24 parents. Irregular configuration of villi, increased quantity of cytoplasmic RNA in enterocytes and decreased activities of membrane enzymes, shift of LDH-monomers in favor of the H-form and a decrease of total activity of lactase and cellobiase were found. The origin of changes, particularly their relation to the ingestion of gluten or to other injuries of the jejunal mucosa as well as to some hereditary mechanism, remains unknown at the present time.

ISSN:0012-2823    

DOI:10.1159/000196918

出版商:S. Karger AG    

年代:1969

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000186310

出版商:S. Karger AG    

年代:1896

数据来源: Karger

摘要:

In 10 patients with acute pancreatitis and in 10 patients with cholelithiasis the thoracic duct was a cannulated and a prolonged external drainage of the lymph was performed. Initial lymph flow per min, total volume of the lymph diverted, and the levels of lymph and blood serum amylase were measured. In patients with acute pancreatitis, the initial lymph flow, lymph and blood serum amylase were found to be significantly higher than those in cholelithiasis. In patients with acute pancreatitis, lymph amylase was significantly higher than blood amylase. Early in the course of acute pancreatitis, there was a considerable increase in lymph flow followed subsequently by a reduction. The prolonged external drainage of the thoracic duct resulted in a rapid improvement of the clinical picture. It is concluded that [1] the thoracic duct lymph is an important pathway for the rise in blood serum enzymes in acute pancreatitis, and [2] by the external drainage of the thoracic duct a considerable amount of toxic substances originating in the necrotic tissues may be removed from the organism.

ISSN:0012-2823    

DOI:10.1159/000196919

出版商:S. Karger AG    

年代:1969

数据来源: Karger

摘要:

Biopsy specimens of human jejunal mucosa were examined with the Stereoscan technique for the first time. With this method it was possible, also for the first time, to represent the three-dimensional structure of the mucosa surface at magnifications of up to × 10,000. In addition to constriction furrows manifested by the villi, a striking feature was the fact that the surface of the individual cells projects hemispherically, with the result that an increase in the absorption surface of at least 25% is achieved. Moreover, a fine nodulation was detected, which we suppose to correspond to the microvilli. Variations in the fine structure of the cell surface between a normal mucosa and one showing slight changes in light microscopic examination, could not be determined

ISSN:0012-2823    

DOI:10.1159/000196920

出版商:S. Karger AG    

年代:1969

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000186311

出版商:S. Karger AG    

年代:1896

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000196921

出版商:S. Karger AG    

年代:1969

数据来源: Karger