摘要:

The effect of a high dose of omeprazole on the plasma gastrin response to feeding and gastric mucosal histamine formation and storage in the dog has been studied. Tissue from the oxyntic gland area was obtained by introduction of an endoscope through a gastric fistula, and biopsies were taken before, after 4 weeks of oral administration of omeprazole and 1 month after withdrawal of the drug. Omeprazole administration increased the basal plasma concentration of gastrin and induced a substantial increase in the feeding response. Histidine-decarboxylase activity was significantly increased after 4 weeks of omeprazole administration, whereas no effect was found on histamine content and mucosal mast cell density. One month after drug withdrawal, the enzyme activity had returned to pretreatment levels.

ISSN:0012-2823    

DOI:10.1159/000199489

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The effect of proglumide, a glutaramic acid derivative, on pancreatic secretion was examined in vivo in the conscious rat with and without the return of bile-pancreatic juice (BPJ) to the intestine. Intravenous infusion of both 300 and 60 mg/kg proglumide significantly decreased protein output in a dose-related manner during BPJ diversion, but did not competely abolish the pancreatic hypersecretory response to BPJ diversion. Conversely, during basal secretion with BPJ being returned to the intestine, 300 mg/kg/h of proglumide increased the protein output. Dibutyryl cyclic GMP infused simultaneously with proglumide did not abolish the stimulatory effect of proglumide on basal secretion. It was concluded that proglumide inhibits pancreatic protein output during stimulated secretion by means of the luminal feedback mechanism but increases protein output during basal (BPJ returned) secretion in the conscious rat.

ISSN:0012-2823    

DOI:10.1159/000199490

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 days. This effect is less pronounced after subcutaneous administration in comparison to oral treatment.

ISSN:0012-2823    

DOI:10.1159/000199491

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplantation of the pancreas. Completeness of vagal pancreatic denervation was confirmed by the missing response of pancreatic protein and the PP response to insulin hypoglycaemia. Total vagal denervation of the pancreas did not alter the PP response to a meal (peak PP levels 402 ± 41 pg/ml before transplantation compared to 510 ± 98 pg/ml after operation). The secretion of PP after food intake seems not to be mediated by direct vagal innervation of the pancreas itself. Since pancreatic autotransplantation results in an interruption of gastropancreatic or enteropancreatic neural reflexes, our results confirm the findings of Debas et al. [Surgery 92: 309–313, 1982] and strongly suggest that the PP response to nutrient stimuli is mediated by a humoral mechan

ISSN:0012-2823    

DOI:10.1159/000199492

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

This study was undertaken to determine the effect of atropine and somatostatin, two inhibitors of intraduodenal pancreatic enzyme secretion, on bombesin-stimulated release of plasma immunoreactive trypsin in 6 healthy volunteers. Infusion of 5 ng/kg·min bombesin during 30 min induced significant increases in plasma trypsin from 206 ± 20 to 334 ± 44 ng/ml (p < 0.01). Atropine (15 ng/kg as i.v. bolus followed by 5 ng/kg•h) had no influence on the bombesin-stimulated increase in plasma immunoreactive trypsin (207 ± 20 to 326 ± 54 ng/ml). Somatostatin (125 μg as i.v. bolus followed by 125 μg/h) also failed to inhibit the plasma trypsin response to bombesin (207 ± 18 to 663 ± 166 ng/ml). These results point to major differences in the regulation of plasma and intraduodenal trypsin

ISSN:0012-2823    

DOI:10.1159/000199493

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The aim of this study was to investigate oesophageal peristalsis and gastro-oesophageal function in normal subjects after 4 days of cisapride 10 mg p.o. 3 times/day and 10 mg 1.5 h before the investigation. The study was carried out in a double-blind cross-over design with coded cisapride or placebo tablets. Basal sphincter pressure increased after cisapride (p < 0.002). The peristaltic pressure amplitude in the oesophageal body as well as the duration and velocity of the peristaltic pressure wave were measured after wet swallows. No changes were found. Intragastric pH was unchanged after cisapride. No effect was found on the result of a standard acid clearing test. Plasma concentration of cisapride did not correlate with any of the other variables. Oral cisapride increases fasting gastro-oesophageal sphincter pressure, but does not influence oesophageal peristalsis, acid clearing or intragastric pH in normal subjects.

ISSN:0012-2823    

DOI:10.1159/000199494

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn’s disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 patients who completed 48-hour stool collections, 41 % had stool fat values exceeding the reference value. Serum retinol concentrations were not significantly correlated with the serum carotene concentrations, with the 48-hour stool fat content, or with the Crohn’s disease activity. In contrast serum retinol concentrations were correlated with the dietary levels of vitamin A. Serum carotene concentrations were inversely correlated with the stool fat content but were not related to Crohn’s disease activity or dietary levels of carotene or total vitamin A. Thus: serum retinol concentrations were normal in this moderately large group of patients with Crohn’s disease and did not reflect a low dietary vitamin A intake by 34% of the population; serum carotene levels were frequently low in patients with Crohn’s disease, possibly due to the presence of steatorrhea, but were not related to low dietary intakes of carotene or to active Crohn’s disease, and (3) a low serum level of carotene does not indicate that the patient is at risk of developing vitamin A

ISSN:0012-2823    

DOI:10.1159/000199495

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

In 36 patients with Crohn’s disease who had been operated with ileal resection but were in a stable clinical condition, the fatty acid composition in the circulation and in adipose tissue was correlated to resection length. Fatty acid composition was also compared to data from a group of randomly selected healthy men and women of similar age. In plasma Crohn patients had reduced circulating levels of unsaturated fatty acids. On the other hand, increased proportions of these fatty acids were found in adipose tissue. It is unlikely that in this group of patients these data are unspecifíc reflections of disease activity. A more reasonable explanation seems to be an increased demand for precursors of local prostaglandin synthesis in the remainig bow

ISSN:0012-2823    

DOI:10.1159/000199496

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Six healthy male volunteers received 1 week’s pretreatment with ranitidine, 150 mg twice daily, and placebo in a double-blind cross-over trial. On the 8th day, each volunteer received 1 g of aspirin in order to study the pharmacokinetics of this nonsteroidal anti-inflammatory drug. The results of this study suggest that ranitidine does not induce clinically significant alterations to the kinetics of a single dose of aspirin in healthy male

ISSN:0012-2823    

DOI:10.1159/000199497

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The effects on cell population kinetics in the distal esophagus of an apple brandy from Normandy (Calvados), of ethanol diluted at a similar concentration, and of saline were investigated in rats. Animals were killed at 0, 6, 12, 18 and 24 h after a single intraesophageal instillation, and at 3 weeks after chronic administration of these solutions. In vivo labeling with [3H]-thymidine and autoradiography were carried out to determine the proliferative parameters. Vincristine sulfate was used to increase metaphase figures during the chronic experiment. Instillation of saline did not modify the parameters under study. Single instillations of both apple brandy and 56° ethanol were followed by a significant increase in labeling (p < 0.01) and mitotic indices (p < 0.01). Chronic administration of both apple brandy and 56° ethanol increased the labeling index (p < 0.01) as well as the metaphase index (p < 0.01). The proliferative responses after the apple brandy and after 56° ethanol were similar in amplitude. These data suggest that ethanol alone may explain the mitogenic effect of Calvados in the esophag

ISSN:0012-2823    

DOI:10.1159/000199498

出版商:S. Karger AG    

年代:1987

数据来源: Karger