摘要:

A family study of 2 parents and 5 SD identical (HLA-A1, A3, B7, B8) siblings, one of whom has ‘classic CAH’ has been used to demonstrate that in this family the maternally inherited HLA-B8 antigen is not solely serving to mark genetic predisposition to this disease. The patient’s lymphocytes both responded to, and stimulated those of her 4 siblings in MLR indicating the possible involvement of an HLA-D antigen in CAH. This HLA-D antigen could have been of paternal origin, or could have been a result of a recombination event involving an HLA-D antigen linked to the maternal HLA-A2, B12 haplotype. The lymphocytes of the four healthy siblings were mutually unresponsive i

ISSN:0012-2823    

DOI:10.1159/000198010

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

108 adult patients and 34 children with chronic active hepatitis (CAH) are divided in four groups on the basis of presence and absence of hepatitis B surface antigen (HBsAg) and autoantibodies (AutoAb). There are significant differences in the numeric distribution among the four groups and the sex distribution between adult patients and children, but no differences in the frequencies of the HLA antigens tested. An increased frequency of HLA-B8 (and HLA-Al) compared with normal controls and the other groups is only found in autoimmune types of CAH, characterized as HBsAg-negative, AutoAb-positive CAH. HBsAg-negative, AutoAb-negative forms of CAH are called cryptogenic CAH and these are most likely non-hepatitis B virus induced types of CAH. In these and hepatitis B virus induced forms of CAH no significant deviation of any HLA antigen tested could be found.

ISSN:0012-2823    

DOI:10.1159/000198011

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

HBs antigen (HBsAg) has been followed up every month in 440 hemodialyzed patients, typed for 26 HLA alleles of the A and B loci. An abnormally high rate of the HLA-A1, B8 association (18.6 %) was found in the group of patients able to eliminate HBsAg, when compared with the normal French population (5.05 %, p < 10-4), and with the group of patients unable to eliminate HBsAg (7.0 %, p < 0.01). Chronic aggressive hepatitis was only found in the latter. This high frequency of the HLA-A1, B8 association has also been found in patients with seronegative active chronic hepatitis and suggests that this phenotype might be associated with high immune response against HBsAg.

ISSN:0012-2823    

DOI:10.1159/000198012

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

42 patients (33 males and 9 females) with chronic active hepatitis (CAH) mostly HBsAg+, were typed for 24 alleles of the A and B loci. Diagnosis was performed according to the criteria outlined by the European Association for the Study of the Liver. The increased frequency of HLA-A3 (47.6 % instead of 19.1 % in 266 healthy controls) is significant after correction. The relative risk is 3.83. The phenotypic association A3/Bw35 is also increased (28.5 % instead of 6.0 in the control group). The risk of the A3/Bw35 association is 6.25. The risk of A3 calculated in patients lacking Bw35 is 1.6. A family study in 5 patients over 5 showed an haplotype A3/Bw35.

ISSN:0012-2823    

DOI:10.1159/000198013

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The HLA antigens in 44 cases of ulcerative colitis and 271 control individuals in Japan were studied. The NIH tissue typing method was used according to the new leukocyte nomenclature adapted by the WHO Committee. In normal Japanese populations, the HLA antigens, which were of high frequency, were HLA A2 (37.3 %), A9 (60.9 %) and B5 (40.6 %). On the contrary, the significantly high frequency of HLA B5 was demonstrated in ulcerative colitis, compared with that in control. Moreover, HLA B5 in cases with ulcerative colitis excluding those with proctitis only, was found with higher frequency than that in total cases. Although the most frequent haplotype was HLA A9-B5 in control, so frequent haplotype was not found in ulcerative colitis. A family study revealed no significant diathesis on the haplotype of HLA in ulcerative colitis. The relationship between MLC locus and ulcerative colitis was not yet clarified from the study of one family whose two members suffered from ulcerative colitis.

ISSN:0012-2823    

DOI:10.1159/000198014

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Fusion of the microvilli of the enterocytes, breakdown of the microvillous structure, vacuolization of the cytoplasm, and separation of the cells from one another, were observed in the early period of anoxia in the isolated small intestinal loop of dog. Filling the intestinal lumen with isotonic glucose solution inhibited the occurrence of the morphological changes observed. These observations furnish new data to the understanding of the very initial stage of small intestinal cell destruction due to anoxia.

ISSN:0012-2823    

DOI:10.1159/000198015

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In a patient a papilla Vateri tumor completely prevented the bile-pancreatic flow into the intestine although the pancreatic juice was secreted into the bile duct via a common channel. Consequently, the bile-pancreatic juice was possible to sample via a percutaneous transhepatic cholangiography (PTC) catheter. This made it possible to study the effect of duodenal infusion of different substances on the bile-pancreatic secretion. In repeated experiments a suppression of the secretion was observed by intraduodenal trypsin as well as the patient’s own bile-pancreatic juice. In the presence of bile-pancreatic juice intraduodenal trypsin inhibitor infusion caused a marked stimulation of the secretion. The results are in accordance with the hypothesis that trypsin in the upper part of the intestine exerts a negative feedback regulation of the pancreatic secretion in ma

ISSN:0012-2823    

DOI:10.1159/000198016

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A patient is presented with Whipple’s disease. Before treatment, Haemophilus influenzae type e, sensitive to tetracycline was cultured from multiple small intestinal biopsies. This isolated micro-organism was structurally similar to the one observed in the tissue. All further culture experiments during and after treatment proved negative except for one biopsy from which a tetracycline-resistant H. influenzae type-e mutant was isolated. The immunological disturbances, mainly characterized by cutaneous anergy, in absence of major humoral or in vitro lymphocytic impairment, regressed during treatment together with clinical remission of the disease. These findings are considered in favour of the secondary nature of the immunological abnormalitie

ISSN:0012-2823    

DOI:10.1159/000198017

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The serum gastrin response to three different amounts of a same meal was studied in 8 normal subjects. The peak gastrin response was similar for the three meals, but the integrated gastrin response was larger with the largest meals. Comparison of the response to the two largest meals indicates that in a given subject the gastrin response is similar when tested on different occasions. A good correlation was found between individual fasting concentrations of gastrin and peak gastrin levels after feeding but not between basal gastrin and integrated gastrin response. This could indicate that in normal subjects the first two parameters are primarily related to the same control mechanisms (possibly the G cell mass), while the integrated gastrin response reflects the effectiveness of the feedback mechanisms controlling gastrin release.

ISSN:0012-2823    

DOI:10.1159/000198018

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A method of in-situ-isolated perfused rat pancreas is described. In situ perfusion of the isolated rat pancreas allows a faster set-up, thanks to a simpler operating procedure. The sensitivity of the isolated rat pancreas has been tested with secretin and cholecystokinin. The pancreas responds to doses of secretin as low as 0.005 CU/kg·h. Such a highly sensitive model might prove to be useful for the bioassay of secretin and the study of the effects of pancreatic secretagogues

ISSN:0012-2823    

DOI:10.1159/000198019

出版商:S. Karger AG    

年代:1977

数据来源: Karger