ISSN:0012-2823    

DOI:10.1159/000191535

出版商:S. Karger AG    

年代:1908

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191536

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

Immunoglobulins in serum and proximal intestinal fluids and secretion of IgA by cultured jejunal mucosa were measured in 12 healthy subjects and 36 patients with Crohn’s disease. Concentrations of IgA, IgG, IgM, and IgE in serum and intestinal fluids were similar in the two groups, except for increased serum IgA concentrations in the patients. Elevation of IgA and chronicity of disease were correlated, which suggests that the IgA alteration was a response to duration of disease rather than a primary pathogenetic factor. IgA secretion by cultured jejunum was similar in control and patient groups. Thus, no evidence was found that abnormalities of secretory immunoglobulins are pathogenetically involved in Crohn’s dise

ISSN:0012-2823    

DOI:10.1159/000197795

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191537

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

The LDH isoenzyme pattern of the uninvolved mucosa of gastric cancer patients differs as regards the LDH isoenzyme pattern from that of similar tissue of patients with benign gastric disease; the former tissue is characterised by a high M/H ratio of the LDH isoenzymes (M and H sub-units). A high M/H ratio characterises antral mucosa when the latter is compared with fundic mucosa. Mucosa showing superficial and atrophic gastritis also has a higher M/H ratio, whereas the presence of intestinal metaplasia does not appear to influence the M/H ratio. These observations are consistent with the concept that the tissue from which the cancer arose may possess a pre-malignant biochemical lesion.

ISSN:0012-2823    

DOI:10.1159/000197796

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191538

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

Peripherally harvested lymphocytes have been labelled with 51Cr, reinjected into human subjects and their distribution then studied. Evidence is presented which suggests faecal loss of 51Cr represents loss of T lymphocytes and that there is normally a pathway of lymphocyte removal into the gut of probable importance in lymphocyte migration streams. In 9 normal subjects, without structural intestinal disease, faecal loss of lymphocytes over 5 days was 0.20 % (SEM ± 0.06) whereas in 5 patients with untreated coeliac disease faecal loss was 1.13 ± 0.34 %, in 7 with Crohn’s disease it was 1.01 ± 0.21 % and in 5 with intestinal lymphangiectasia loss was 0.61 ± 0.10%. In 1 patient with acute tropical sprue, enteric loss was 0.97 %. By contrast, faecal loss was normal in 3 coeliac patients in remission on a gluten-free diet. Measurements were also made using an external counter. In contrast to the normals, where count rates steadily diminished, an increasing activity was recorded over the umbilicus over 7 days after dose administration in all the disease categories studied with the exception of the treated coeliacs. The finding of an increased enteric loss of lymphocytes may explain many of the immunological abnormalities in the conditions st

ISSN:0012-2823    

DOI:10.1159/000197797

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191539

出版商:S. Karger AG    

年代:1908

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191540

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

In conscious cats with chronic gastric and pancreatic fistulas, the natural prostaglandins (PGs) of the E (PGE1 and PGE2) and F (PGF1α and PGF2α) series and synthetic 15-methyl analog of PGE2, 15(S) 15-methyl-PGE2methylester were compared with regard to their action on gastric and pancreatic secretions and peptic ulcer formation. This study indicates that in comparison with natural PGs, the synthetic 15-methyl analog of PGE2 is a more potent inhibitor of gastric secretion regardless of the route of administration and the mode of gastric stimulation. It more effectively prevents the formation of peptic ulcers in conscious cat

ISSN:0012-2823    

DOI:10.1159/000197798

出版商:S. Karger AG    

年代:1976

数据来源: Karger