ISSN:0012-2823    

DOI:10.1159/000199846

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats. Animals were treated with indomethacin (5 mg/kg, s.c, once daily) and histamine (40 mg/kg, s.c, 3 times every 2.5 h after indomethacin treatment) for 2 days under fasting conditions, and they were fed normally thereafter. The duodenal ulcers so induced were confined to the proximal part of the duodenum and penetrated to the muscular mucosa with an incidence of over 80% when determined 32 h after the first injection of indomethacin (day 1). The ulcers became smaller and shallower within 7 days with granulation from the ulcer base, the mucosa grew in from the edges over the surface of granulation tissue, and they had healed almost completely after 15 days with epithelial regeneration from the edge of the ulcers. The healing of ulcers was significantly promoted by a 5-day treatment with an antacid (Al(OH)3) as well as antisecretory agents (omeprazole, cimetidine, propantheline bromide) and 16,16-dimethyl prostaglandin E2 at the dose which produced a potent inhibition of acid output and a marked increase in duodenal alkaline secretion. These results suggest that the duodenal ulcers induced in rats by indomethacin + histamine may provide a useful model for studying the healing process of duodenal ulcers and for the evaluation of the drugs with possible effects on ulcer healing.

ISSN:0012-2823    

DOI:10.1159/000199847

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

The association between colonic neoplasms and gastric polyps (GP) was evaluated. Two hundred and sixty patients with known colonic neoplasms undergoing gastroduodenoscopy for abdominal symptoms, with or without anemia, were evaluated for the occurrence of synchronous GP. There were 100 patients with 1–4 colonic adenomas, 80 patients with multiple (5 or more) colonic adenomas and 80 patients with colorectal cancer. One hundred patients free from colonic neoplasms, investigated for abdominal pain or anemia, served as controls. The overall occurrence of GP in patients with colonic neoplasms was 18.8% compared to 1 % in the control group. Hyperplastic GP were found in 4, 22.5, 18.7 and 1 % of these patients, respectively, while gastric adenomas occurred in 2, 3.7, 3.5 and 0%, respectively. Patients with colorectal cancer or multiple colonic adenomas had significantly more GP than patients with 0–4 colonic adenomas. It is suggested that gastroduodenoscopic evaluation should be performed in patients with colorectal cancer or with 5 or more colonic adeno

ISSN:0012-2823    

DOI:10.1159/000199848

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Rioprostil, a primary alcohol prostaglandin E1 analog, prevents gastric lesion formation induced by a variety of irritants, including aspirin, in rats and dogs. In the present study, rioprostil reduced both gastric lesion formation and fecal blood loss in dogs caused by daily aspirin administration (1,950 mg/day) for 3 consecutive days. A gastric antisecretory dose of 100 μg/kg p.o. t.i.d. of rioprostil reduced fecal blood loss by 96% to a level (0.76 ± 0.10 mg Hb/g stool) similar to basal blood loss in non-aspirin-treated vehicle dogs (0.61 ± 0.08 mg Hb/g stool) as determined by HemoQuant® assay. A nonantisecretory dose of rioprostil (1 μg/kg p.o. t.i.d.) reduced fecal blood loss by 70% compared to vehicle-treated dogs. Gastric lesion severity scores in dogs treated with 100 or 1 μg/kg p.o. t.i.d. of rioprostil were 61 and 52% lower, respectively, than the mean severity score in the vehicle-treated group. There was a highly significant (p < 0.001) correlation between gastric lesion score and fecal blood loss independent of the treatment each dog received. The efficacy of a nonantisecretory dose suggests that the gastric lesion effect of rioprostil may be independent of gastric antisecretory effects. The correlation of fecal blood loss with gastric lesion score suggests the possibility that either measurement may be used as an indication of gastric lesion occurrence or sev

ISSN:0012-2823    

DOI:10.1159/000199849

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Recurrence rate is high after operation for Crohn’s disease. A multicenter trial was performed to study the effect of radical or nonradical operation and of sulfasalazine prophylaxis versus placebo on postoperative recurrence rate in 232 patients with Crohn’s disease. Sixteen medical and surgical centers participated in the study, 7 operating radically and 9 nonradically. The follow-up period lasted 3 years, the allocation to drug treatment was randomized and double blind. Recurrence was significantly less frequent and occurred later in patients who were operated nonradically. Patients on sulfasalazine prophylaxis had a better prognosis than on placebo. This effect was statistically significant in the first 2 years of treatment. Both strategies were additive: nonradical operation and sulfasalazine had the best prognosis, radical operation and placebo was worst. It is concluded that postoperative recurrence is best prevented by resecting nonradically and prescribing 3 g of sulfasalazine daily at least over 2 ye

ISSN:0012-2823    

DOI:10.1159/000199850

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000199851

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000199852

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000195229

出版商:S. Karger AG    

年代:1928

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000195230

出版商:S. Karger AG    

年代:1928

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000195231

出版商:S. Karger AG    

年代:1928

数据来源: Karger