摘要:

AbstractMammalian alcohol dehydrogenases (ADHs) constitute an enzyme family of multiple forms (isozymes) which are differentially distributed throughout the body. Subunit types α, β and γ in dimeric combinations constitute the isozymes of human liver class I ADH, and are>94% homologous in structure. Human π and χ subunits form homodimeric Class II and III ADH isozymes. π‐ADH is liver specific whereas χ‐ADH is widely distributed throughout the body. A sixth human ADH subunit (designated μ or σ), forming a new dimeric human stomach ADH, has been recently reported as Class IV ADH. Evidence for a seventh human ADH subunit has also been described, designated as Class V, the transcripts having been reported in the stomach and liver. All five classes of ADH represent isozymes which are homologous but exhibit at least 30% sequence differences in primary srtructure. Kinetic analyses of four of these classes of ADH indicated differential functions, serving either in the oxidative or reductive mode. Studies from various laboratories indicate the following respective functions: oxidation of aliphatic and aromatic alcohols—liver Class I and Class II, and stomach Class IV ADHs; reduction of peroxidic aldehydes—Classes I, II and IV; ‘biogenic’ alcohol oxidation—Classes I and II; and glutathione‐dependent formaldehyde

ISSN:0959-5236    

DOI:10.1080/09595239300185781

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

AbstractA critique is offered of the Distilled Spirits Industry Council position paper ‘Alcohol Availability’. It is argued that this position paper presents a simple‐minded analysis of the complex relationship between the availability of alcohol and its consumption which pays no attention to the importance of price in determining consumption. As a consequence, it misconstrues the lessons to be drawn from the Victorian experiment in liberalization and fails to consider its implications for the incidence of alcohol related pro

ISSN:0959-5236    

DOI:10.1080/09595239300185791

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Book reviewed in this article:Natural Experiments with Decreased Availability of Alcoholic Beverages: Finnish Alcohol Strikes in 1972 and 1985ESA OSTERBERG&SIRKKA‐LIISA SAILA, (Eds)Alcohol in America: Drinking Practices and ProblemsWALTER B. CLARK&MICHAEL E. HILTON, (Eds)Women with Alcoholic HusbandsRAMONA M. ASHERFeminism and AddictionCLAUDIA BEPKO (Ed

ISSN:0959-5236    

DOI:10.1080/09595239300185801

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0959-5236    

DOI:10.1080/09595239300185811

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY