摘要:

ABSTRACT—The purpose of this investigation was to ascertain the prevalence and manifestations of tumorous invasion of the lumen of the bile ducts, a mode of local extension characteristic of hepatocellular carcinoma. In a series of 140 necropsied patients with hepatocellular carcinoma, tumorous invasion of the bile duct was noted in three patients (2.1 %). Marked cholestasis was present in these three patients; the other manifestations related to the tumorous invasion of the bile duct were biliary pain in one and gall‐bladder enlargement in two patie

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00040.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT—Hepatic venograms made in 40 authentic cases of idiopathic portal hypertension (Banti's syndrome) were compared with 13 normal venograms and venograms obtained in 88 cases of cirrhosis, and analyzed in the light of the pathological changes seen in 16 postmortem liver specimens. There were frequent anastomoses between hepatic vein radicles, approximation of middle‐size branches to the liver surface, reduction in the angles between the main hepatic vein and its tributaries, and difficulty in opacifying portal vein branches in wedged retrograde portography. These angiographic alterations were corroborated by gross pathological findings which comprised displacement of middle‐size hepatic vein branches closer to the liver surface and their approximation among themselves, and seem to be accounted for by the disappearance of liver parenchyma secondary to the peripheral portal circulatory fa

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00041.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT—Mononuclear cell cytotoxicity against autologous, allogeneic and xenogeneic (rabbit) hepatocytes was investigated in nine baboons fed alcohol for 17–21 months and in nine pair‐fed controls. All alcohol‐fed animals developed fatty liver. Cytotoxicity of mononuclear cells was not observed when rabbit hepatocytes were used as target cells, but mononuclear cells of alcohol‐fed baboons were cytotoxic against hepatocytes of both control animals and hepatocytes from alcohol‐fed baboons, including the animals' own hepatocytes. Increased vulnerability of hepatocytes of alcohol‐fed baboons was also demonstrated since mononuclear cells of both controls and alcohol‐fed animals were more cytotoxic against hepatocytes of alcohol‐fed baboons than against those of controls. Thus, autologous and heterologous hepatocytes are more sensitive in the baboon than rabbit hepatocytes in demonstrating cytotoxicity already at the stage of fatty liver. Two factors are contributory: mononuclear cells cytotoxicity and vulnerabili

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00042.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT—Cellular immune reactions against normal biliary tract antigens have been investigated in 21 patients with primary biliary cirrhosis (PBC) and 18 with chronic active hepatitis (CAH) using the leucocyte migration inhibition test with partially purified antigens from normal human gall‐bladder bile. Four antigen fractions, containing (either separately or together) three previously‐described biliary antigens, were employed: (1) Antigen I; (2) Canalicular antigen; (3) Canalicular and Ductular antigens; (4) All three antigens. Seventeen (81%) of the PBC patients showed migration inhibition with all four fractions. Five (28%) of the CAH patients showed inhibition with three fractions but none exhibited sensitization to the fraction containing only the antigen derived from the bile canalicular portion of the hepatocyte membrane. In experiments with purified lymphocyte sub‐populations from PBC patients, leucocyte migration inhibitory factor production was shown to be a function of T‐lymphocytes. The antigenic selectivity with respect to the responses in CAH patients suggests that sensitization to biliary tract antigens is probably not a secondary phenomenon resulting from »unmasking« of antigens after bile duct damage has occurred but may be more directly related to the dise

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00043.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT—Six autopsy cases of the rare, diffuse type of hepatocellular carcinoma (HCC), as classified gross anatomically according to the strict definition, have been studied. The prominent clinical feature was the rapid deterioration of the patient's general condition, terminating in hepatic failure. The liver size enlarged quickly, at a perceptible speed, often accompanied by abdominal pain. Diagnosis of this particular type of HCC was difficult, and celiac angiography and scintiscan of the liver were only suggestive when considered together with other laboratory data. Hepatitis B surface antigen was positive in all three patients in whom it was tested. The entire liver was studded with minute, uniformly sized tumor nodules, evenly distributed throughout. Some of them were grossly indistinguishable from cirrhotic nodules. All livers had an underlying cirrhosis which was characterized by relatively small regenerative nodules with thin stromas. Large portal branches at the hilum contained tumor thrombi in all patients, except for one case in which left lobectomy was followed by intraportal dissemination. Histologically, all tumor nodules represented intrahepatic metastases via the portal vein system. Tumor cells were poorly differentiated. These findings suggest that the diffuse type of HCC most frequently, if not always, represents intrahepatic, widespread portal metastases which have occurred within a short period of tim

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00044.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT—The presence and persistence of IgM antibody against hepatitis B core antigen (anti‐HBc IgM) and the correlation with other HBV markers were studied in 42 patients, all of whom had acute HBsAg‐positive hepatitis but whose subsequent diseases differed. All patients initially had anti‐HBc IgM. In 13 out of 15 patients with uncomplicated acute hepatitis, anti‐HBc IgM disappeared within 6 months after onset of the disease. In five out of 12 patients, who in spite of transient HBsAg developed chronic liver disease, the anti‐HBc IgM persisted for more than 2 years. Among 15 patients with persistent HBsAg, anti‐HBc IgM was present from 7 months to more than 8 years. Seroconversion from HBeAg to anti‐HBe was observed in seven patients and in five of these anti‐HBc IgM disappeared during the follow‐up period. These results indicate that anti‐HBc IgM can be used as a serological marker of recent or

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00045.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00046.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1981.tb00047.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY