摘要:

AbstractFour cloned continuously cultured mouse B lymphoma cells of the lines WEHI‐279, BCL1and 38C‐13 were used to study the surface presentation of IgM. Cells of all lines expose, in addition to μ2L2, various disulfide‐linked subunits as already shown for normal B lymphocytes (Koch, N. and Haustein, D.,Mol. Immunol.1982.19: 477). In contrast to normal B cells, B lymphoma cells also carry IgM structures of higher molecular weight than μ2L2on their surface. Furthermore, B lymphoma cells of all investigated lines expose a μ2L2structure to which a 30‐kDa protein is disulfidelinked. This 30‐kDa protein could also be identified on normal mouse B lymphocytes when more drastic conditions were employed. μ2L2disulfide linked to this 30‐kDa protein is the main IgM structure on normal and neoplastic B cells whereas only small amounts of μ2L2(unlinked to this protein)

ISSN:0014-2980    

DOI:10.1002/eji.1830160122

出版商:WILEY‐VCH Verlag GmbH    

年代:1986

数据来源: WILEY

ISSN:0014-2980    

DOI:10.1002/eji.1830160123

出版商:WILEY‐VCH Verlag GmbH    

年代:1986

数据来源: WILEY

ISSN:0014-2980    

DOI:10.1002/eji.1830160101

出版商:WILEY‐VCH Verlag GmbH    

年代:1986

数据来源: WILEY