摘要:

SummaryCells forming the haemolytic type of anti‐SIII antibody were counted in muse spleens by a plaque method. Plaque‐forming cells were shown to be present after low doses of antigen (when haemagglutinating and haemolytic antibodies were circulating) and after moderately high doses (when only haemolytic antibodies were detectable), but not after very high doses (when all circulating antibody was absent). Plaque‐forming cells were also found under certain conditions (early in the immune response or in the presence of high titres of haemagglutinating antibody) when haemolytic antibody was not apparent in the serum. These findings are discussed in terms of competition between the two antibodies and preferential neutralization of haemagglutinating antibody by antigen.As far as haemolytic antibody is concerned, immunological paralysis after high doses of SIII appears to be a central inhibition of antibody‐forming cells.Primary immune responsesin vitrowere demonstrated with normal mouse spleen cells treated with SIII. A moderate dose of antigen elicited significant numbers of specific plaque‐forming cells. A high dose produced a situation analogous to paralysis.

ISSN:0004-945X    

DOI:10.1038/icb.1970.22

出版商:Nature Publishing Group    

年代:1970

数据来源: WILEY

摘要:

SummaryAcrylamide gel electrophoresis of sera fromSminthopsis crassicaudatahas revealed a pattern of three amylase isoenzyme bands. Three mobility variants (A, B and C) of this pattern have been found. One individual has been found to have a combination of the A and B patterns. Thirteen sera fromS. larapintaall had a serum amylase phenotype identical to that of the A variant ofS. crassicaudata.There is evidence that of the three isoenzyme bands inS. crassicaudatathe most cathodic is of enzyme produced by the pancreas, while the other two are due to this enzyme with residues of sialic acid bound to it.

ISSN:0004-945X    

DOI:10.1038/icb.1970.23

出版商:Nature Publishing Group    

年代:1970

数据来源: WILEY

ISSN:0004-945X    

DOI:10.1038/icb.1970.24

出版商:Nature Publishing Group    

年代:1970

数据来源: WILEY

ISSN:0004-945X    

DOI:10.1038/icb.1970.25

出版商:Nature Publishing Group    

年代:1970

数据来源: WILEY

摘要:

Summary“Natural” antibodies to flagellin fromSalmonella adelaide(SW 1338) were detected by tanned cell haemagglutination in 79% of 611 men, women and children. These antibodies were not detected in cord blood, but became demorstrable in serum within two weeks of birth, after which the incidence of antibodies increased, and titres rose to a peak in the twenties. Thereafter titres fell slowly. Natural antibodies to fiagellin were of IgM class and were specific for flagellin fromSalmonella adelaide.Studies on natural antibodies to flagellin, an antigen of restricted provenance, should clarify how natural antibodies originate and what relation they have to immune antibodies.

ISSN:0004-945X    

DOI:10.1038/icb.1970.26

出版商:Nature Publishing Group    

年代:1970

数据来源: WILEY