摘要:

SummaryThe mechanism of resistance of guinea‐pigs to infection withTrichostrongylus colubrifomiswas investigated by transferring serum and mesenteric lymph nodes from resistant guinea‐pigs to susceptible guinea‐pigs of the same inbred strain. Inbred guinea‐pigs were used in these studies to avoid destruc tion of the transferred tissues by a homograft reaction.It was shown that the transfer of mesenteric lymph nodes prevented a primary infection from reaching patency in recipient guinea‐pigs, whereas a single injection of serum from resistant donors did not have any observable effect on the development of primary infection.It is concluded that the failure of susceptible guinea‐pigs to become infected withT. colubriformiswas due to an immunological reaction in which cellular factors were more important than humoral antibodies. It is suggested that control ofT. colubriformisand other helminth parasites with all stages confined to the alimentary tract may be mediated by a delayed type of hypersensitive reaction.

ISSN:0004-945X    

DOI:10.1038/icb.1965.77

出版商:Nature Publishing Group    

年代:1965

数据来源: WILEY

摘要:

SummaryCell suspensions prepared from the avian thymus and bursa of Fabricius were tested for immunological competence by their ability to give graft versus host reactions, as assessed by the production of lesions on the chorioallantoic membrane of chick embryos. Thymic cell suspensions were more active than bursal cells by a mean factor of six.Bursal cell suspensions contained more plasma cells, and bursal extracts contained higher titres of a natural haemagglutinin than did thymic extracts.There was a greater uptake of the radioisotope32P by bursal cells than by thymic cells, bothin vivoandin vitro. After incubationin vitrowith3H‐thymidine, 20 per cent of bursal cells and 9 per cent of thymic cells were labelled.Transfusion of labelled bursal and thymic cells into young normal recipient chicks showed that more thymic cells “homed” to the spleen.The results are discussed in relation to the concept of a dissociation of immunological responsiveness in the chicken.

ISSN:0004-945X    

DOI:10.1038/icb.1965.78

出版商:Nature Publishing Group    

年代:1965

数据来源: WILEY

摘要:

Antibody production in mammals in response to a variety of antigens has been extensively investigated. An early appearance of IgM antibodies was usually followed by IgG antibodies (Bauer, Mathies and Stavitsky, 1963). The activity of IgM antibodies was destroyed by treatment with 0·1M2‐mercaptoethanol (ME) (Deutsch and Morton, 1957), whilst the titre of IgG antibodies was not diminished. In the fowl a similar pattern of antibody response has been described (Uhr, Finkelstein and Franklin. 1962; Benedict. Brown and Hirsch, 1963; Drecsman, Larson, Pinckard, Groydon and Benedict, 1965). Rosenquist and Gilden (1963), however, found no IgM antibodies in fowl serum in response to bovine serum albumin (BSA) and the antibody titre in the IgG fraction was destroyed by incubation with ME.The results presented in this communication are concerned with (1) the susceptibility of fowl IgG antibodies to ME treatment; and (2) the production of IgM antibodies by the fowl.

ISSN:0004-945X    

DOI:10.1038/icb.1965.79

出版商:Nature Publishing Group    

年代:1965

数据来源: WILEY