ISSN:0004-945X    

DOI:10.1038/icb.1976.13

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummaryMastocytoma cells (P‐185) have been separated by velocity sedimentation into fractions which were highly enriched for cells at discrete stages of the cell cycle. By scanning electron microscopy it was shown that the surface morphology of the majority of cells in each fraction was characteristic of that fraction. No difference could be detected between isolated fractions and unfractionated cells in their ability to be lysed by cytotoxic lymphocytes.

ISSN:0004-945X    

DOI:10.1038/icb.1976.14

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummaryResistance to Krebs ascites tumour, sarcoma S180 (ascitic form) and PC6 plasmacytoma can be induced with prior immunisation with liveSalmonella enteritidis11RX. One thousand to ten thousand more tumour cells are needed to give an LD50after immunisation. Resistance to PC6 could be recalled 137 days after intravenous immunisation with 11RX protein antigen intraperitoneally as measured by prolonged survival or monitoring the death of 5[131I]‐iodo‐2′‐deoxyuridine labelled tumour cellsin vivo. The range of tumours to which resistance can be produced by 11RX immunisation suggests that the mechanism of resistance does not involve antigens common to the tumours andSalmonella enteritidis11RX.

ISSN:0004-945X    

DOI:10.1038/icb.1976.15

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummarySuppression of growth of a number of different murine tumours, injected subcutaneously or into the foot pad, was induced by prior intraperitoneal or intravenous immunisation withSalmonella enteritidis11RX. The effect of immunisation on tumour growth was relatively minor, but could be enhanced by addition of 11RX antigen preparations to the suspensions of tumour cells used for challenge. The significance of these findings is discussed.

ISSN:0004-945X    

DOI:10.1038/icb.1976.16

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummaryThe contributions of the sympathetic nervous system and the adrenal medullary catecholamines to the response of dog hind limb resistance vessels to haemorrhage were examined. Anaesthetized dogs were bled either 30% or 45% of blood volume. There was little difference between the vascular conductance response in untreated hind limbs and sympathectomized limbs. Conductance in limbs that had been both sympathectomized and alpha‐adrenergically blocked with phenoxybenzamine was markedly above that of untreated limbs. Blood flow in both the untreated limbs and the sympathectomized limbs was closely similar to that predicted from the pressure‐flow curve for the hind limbs obtained in non‐bled dogs. Flow was higher than predicted in the limbs with combined sympathectomy and alpha‐adrenergic blockade. It is concluded that the sympathetic nervous system exerted little vasoconstrictive influence after haemorrhage, but that circulatory catecholamines exerted a strong vasoconstrictive influence that was opposed in the normal limbs by an almost equally powerful vasodilatory force of undetermined origin.

ISSN:0004-945X    

DOI:10.1038/icb.1976.17

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummaryGastric pouches were constructed in 8 dogs; in 4 they were of denervated type and in 4 the innervation was intact. An oesophageal fistula was then prepared in each dog. The acid secretory response to oral, tube and sham feeding was determined before and after denervation of the pyloric antrum. The results support the view that vagal release of gastrin makes a relatively small contribution to the total acid secretory response to food.

ISSN:0004-945X    

DOI:10.1038/icb.1976.18

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummaryA comparative study was made on the secretion of IgG1and IgA into parotid and submaxillary saliva of sheep. The purpose of the study was to examine the suggestion that in the external secretory organs of ruminants there is an inverse relationship between the capacity to selectively transfer IgG1and the development of the IgA secretory system. Despite a marked difference in the secretion of IgA between the parotid and submaxillary salivary glands, the magnitude of selective transfer of IgG1was similar. Thus, there appears to be no relationship between the selective transfer of IgG1and the secretion of IgA into the saliva of sheep.

ISSN:0004-945X    

DOI:10.1038/icb.1976.19

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummaryHistamine produced significantly greater vasodilation in rabbit ear arteries constricted by noradrenaline than when the same arteries were constricted by either caffeine or barium. Histamine dilation in the presence of caffeine was also significantly greater than that in the presence of barium. These results suggest that histamine may produce vasodilation through at least two different modifications of intracellular calcium mobilisation.

ISSN:0004-945X    

DOI:10.1038/icb.1976.20

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY

摘要:

SummaryOf the 104 isolations ofSalmonellasp. from egg pulp, 97 were obtained from strontium chloride M broth, 42 from strontium selenite broth and 57 from strontium selenite A broth. The results suggest that the first medium may be used more successfully than bi‐selenite based media for enrichment and subsequent detection of salmonellae in egg products; however, the growth of S.pullorumwas not satisfactory in strontium chloride M broth.

ISSN:0004-945X    

DOI:10.1038/icb.1976.21

出版商:Nature Publishing Group    

年代:1976

数据来源: WILEY