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11. |
Bromocriptine Therapy in Multiple SclerosisAn Open Label Pilot Study |
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Clinical Neuropharmacology,
Volume 17,
Issue 5,
1994,
Page 473-476
Véronique Bissay,
Nina Klippel,
Luc Herroelen,
Eric Schmedding,
Therèse Buisseret,
Guy Ebinger,
Jacques Keyser,
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摘要:
SummaryBromocriptine suppresses the duration and severity of clinical signs of experimental allergic encephalitis, which is considered as an animal model for multiple sclerosis (MS). We conducted an open pilot study with 2.5 mg of bromocriptine two times a day on 18 patients with clinically or laboratory-supported definite MS (10 with the relapsing-remitting form and eight with the chronic progressive form). After 1 year of treatment, 14 of the 15 patients who completed the study showed disease progression as evidenced by one or more of the following parameters: worsening of the EDSS score, clinical relapses, appearance of new lesions on MRI of the brain and brainstem, or increased latencies of visual or auditory evoked responses. These findings indicate that bromocriptine does not completely suppresses ongoing disease activity in patients with multiple sclerosis.
ISSN:0362-5664
出版商:OVID
年代:1994
数据来源: OVID
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12. |
Clozapine for the Control of Hemiballismus |
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Clinical Neuropharmacology,
Volume 17,
Issue 5,
1994,
Page 477-480
Khurram Bashir,
Bala Manyam,
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PDF (255KB)
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摘要:
SummaryPharmacological agents used for the control of ballistic movements include chloral hydrate, barbiturates, paraldehyde, bromides, phenothiazines, progabide, haloperidol, pimozide, reserpine, tetrabenazine, sodium valproate, and dimethylaminoethanol. These agents are believed to act by different mechanisms, including modification of dopaminergic, GABAergic, or cholinergic mechanisms. We report a case where, after failure of haloperidol, phenobarbital, and pimozide, the hemiballistic movements were controlled with clozapine.
ISSN:0362-5664
出版商:OVID
年代:1994
数据来源: OVID
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13. |
Tardive Akathisia Due to Sulphide |
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Clinical Neuropharmacology,
Volume 17,
Issue 5,
1994,
Page 481-483
A. de Munain,
J. Poza,
A. Gorospe,
A. Arce,
J. Martí Massó,
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PDF (181KB)
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摘要:
SummaryA 56 year-old woman who suffered from parkinsonism, oro-lingual dyskinesia (OLD) and tardive akathisia (TA) due to sulpiride is reported. OLD and TA appeared after sulpiride withdrawal. The patient was successfully treated with tetrabenazine even a mild parkinsonism was present. TA seems to be related with an apparent dopaminergic hyperactivity and it has to be differentiated of other neuroleptic-induced movement disorders such as restless legs syndrome in order of an appropriate treatment. Sulpiride has the same possible side effects than classic neuroleptics.
ISSN:0362-5664
出版商:OVID
年代:1994
数据来源: OVID
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14. |
Genetic Polymorphism of Cytochrome P450 2D6 in Idiopathic Parkinson Disease and Diffuse Lewy Body Disease |
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Clinical Neuropharmacology,
Volume 17,
Issue 5,
1994,
Page 484-488
R. Bordet,
F. Broly,
A. Destee,
Ch. Libersa,
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PDF (284KB)
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摘要:
SummaryWe investigated genetic polymorphism of the cytochrome P450 CYP 2D6 gene in 105 Caucasian patients with idiopathic Parkinson's disease (IPD) and 15 patients with diffuse Lewy body disease (DLBD). The mutations of the CYP 2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA by a polymerase chain reaction (PCR)-based DNA amplification combined with Xba I restriction fragment length polymorphism (RFLP) analysis. The rate of genotypically defined PM and the frequencies of the mutation D6-B were not significantly different in IPD and DLBD patients. This study fails to find a relationship between CYP 2D6 impairment and neuropathological lesions diffusion in IPD and DLBD. This study cannot exclude involvement of neuronal expression of CYP 2D6.
ISSN:0362-5664
出版商:OVID
年代:1994
数据来源: OVID
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15. |
Ranitidine‐Induced Cranial Dystonia |
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Clinical Neuropharmacology,
Volume 17,
Issue 5,
1994,
Page 489-491
Bradley Davis,
Edward Aul,
Mark Granner,
Robert Rodnitzky,
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PDF (159KB)
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摘要:
SummaryWe report a case of cranial dystonia related to the administration of ranitidine. The symptoms started shortly after institution of treatment, resolved after discontinuation, and recurred upon repeat administration of the drug. Although there have been a few reports of abnormal involuntary movements related to other histamine2 antagonists, this is only the second reported instance due to ranitidine and the first reported instance of dystonia related to the drug. The pathophysiology of this effect is unclear, but a central cholinergic effect of this agent may be a contributing factor.
ISSN:0362-5664
出版商:OVID
年代:1994
数据来源: OVID
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16. |
Beneficial Effect of a Treatment with Xylitol in a Patient with Myoadenylate Deaminase Deficiency |
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Clinical Neuropharmacology,
Volume 17,
Issue 5,
1994,
Page 492-493
M. Bruyland,
G. Ebinger,
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PDF (81KB)
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ISSN:0362-5664
出版商:OVID
年代:1994
数据来源: OVID
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